SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t2f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 1t2f L-LACTATE
DEHYDROGENASE B
CHAIN
(Homo
sapiens) 		5 / 9 VAL A  26
GLY A  27
ASP A  52
TYR A  83
ALA A  96
 None
NAD  A 401 ( 4.5A)
NAD  A 401 (-2.5A)
None
NAD  A 401 ( 4.1A)
 0.59A 1cetA-1t2fA:
38.8		 1cetA-1t2fA:
30.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 1t2f L-LACTATE
DEHYDROGENASE B
CHAIN
(Homo
sapiens) 		3 / 3 TRP A 148
ARG A 106
THR A 147
 None
OXQ  A 402 (-4.4A)
None
 0.85A 1df7A-1t2fA:
undetectable		 1df7A-1t2fA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 1t2f L-LACTATE
DEHYDROGENASE B
CHAIN
(Homo
sapiens) 		5 / 12 VAL A 135
VAL A  31
VAL A 146
ILE A 142
THR A 147
 None
NAD  A 401 (-3.7A)
None
None
None
 1.13A 3czhA-1t2fA:
undetectable		 3czhA-1t2fA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 1t2f L-LACTATE
DEHYDROGENASE B
CHAIN
(Homo
sapiens) 		5 / 12 VAL A 135
VAL A  31
VAL A 146
ILE A 142
THR A 147
 None
NAD  A 401 (-3.7A)
None
None
None
 1.16A 3dl9A-1t2fA:
undetectable		 3dl9A-1t2fA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 1t2f L-LACTATE
DEHYDROGENASE B
CHAIN
(Homo
sapiens) 		4 / 7 LEU A 330
VAL A 146
VAL A 110
ASP A 141
 None
 0.96A 3rgfA-1t2fA:
undetectable		 3rgfA-1t2fA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1t2f L-LACTATE
DEHYDROGENASE B
CHAIN
(Homo
sapiens) 		5 / 10 GLY A  27
ALA A  34
GLY A  32
VAL A 136
CYH A  35
 NAD  A 401 ( 4.5A)
None
None
NAD  A 401 (-4.0A)
None
 1.34A 4c5nD-1t2fA:
5.4		 4c5nD-1t2fA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 1t2f L-LACTATE
DEHYDROGENASE B
CHAIN
(Homo
sapiens) 		3 / 3 LYS A  22
PRO A  19
LYS A  76
 None
 1.50A 4duzL-1t2fA:
0.0		 4duzL-1t2fA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1t2f L-LACTATE
DEHYDROGENASE B
CHAIN
(Homo
sapiens) 		4 / 8 ASN A 164
PRO A 292
LEU A 300
LEU A 295
 None
 0.91A 4jjkA-1t2fA:
undetectable		 4jjkA-1t2fA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1t2f L-LACTATE
DEHYDROGENASE B
CHAIN
(Homo
sapiens) 		4 / 8 PRO A 272
SER A 290
VAL A 273
GLY A 187
 None
 1.01A 4mk4A-1t2fA:
3.4		 4mk4A-1t2fA:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 1t2f L-LACTATE
DEHYDROGENASE B
CHAIN
(Homo
sapiens) 		6 / 9 ASP A  52
VAL A  53
TYR A  83
ALA A  96
ARG A  99
ILE A 120
 NAD  A 401 (-2.5A)
NAD  A 401 (-4.4A)
None
NAD  A 401 ( 4.1A)
NAD  A 401 (-4.3A)
NAD  A 401 (-4.2A)
 1.33A 4oknB-1t2fA:
47.3		 4oknB-1t2fA:
75.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1t2f L-LACTATE
DEHYDROGENASE B
CHAIN
(Homo
sapiens) 		4 / 5 ILE A 134
VAL A 256
ILE A  39
VAL A  93
 None
 0.73A 4xdtA-1t2fA:
undetectable		 4xdtA-1t2fA:
18.75