SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t2k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 1t2k INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		5 / 12 ALA A  93
LEU A  16
VAL A  13
LEU A  12
ILE A  36
 None
 0.95A 1df7A-1t2kA:
undetectable		 1df7A-1t2kA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1t2k TRANSCRIPTION FACTOR
AP-1
(Homo
sapiens) 		3 / 3 ILE C 277
LEU C 280
VAL C 284
 None
 0.22A 1mz9B-1t2kC:
4.0		 1mz9B-1t2kC:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1t2k INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		4 / 7 TYR A 107
ILE A  36
ARG A  81
PHE A  54
 None
 0.99A 2vctD-1t2kA:
undetectable		 2vctD-1t2kA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 1t2k INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		4 / 5 TYR A 107
ILE A  36
LEU A  16
LEU A  12
 None
 1.12A 2zb7A-1t2kA:
undetectable		 2zb7A-1t2kA:
16.31