SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t2q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1t2q FAB NNA7 LIGHT CHAIN
(Mus
musculus) 		5 / 11 VAL H 189
LEU H 165
SER H 164
THR H 193
GLU H 197
 None
 1.37A 1mmtA-1t2qH:
undetectable		 1mmtA-1t2qH:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 1t2q FAB NNA7 LIGHT CHAIN
(Mus
musculus) 		4 / 6 VAL H  38
LEU H  49
PHE H  64
MET H  83
 None
 1.12A 1x8vA-1t2qH:
undetectable		 1x8vA-1t2qH:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 1t2q FAB NNA7 LIGHT CHAIN
(Mus
musculus) 		3 / 3 SER H  77
HIS H  36
ASP H  59
 None
 0.64A 2wa2B-1t2qH:
undetectable		 2wa2B-1t2qH:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 1t2q FAB NNA7 LIGHT CHAIN
(Mus
musculus) 		3 / 3 THR H 116
GLU H 154
HIS H 205
 None
 0.70A 3g1uB-1t2qH:
undetectable		 3g1uB-1t2qH:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 1t2q FAB NNA7 LIGHT CHAIN
(Mus
musculus) 		4 / 8 TYR H  94
ASP H  89
PHE H  64
LEU H  49
 None
 0.83A 4f8hA-1t2qH:
1.2
4f8hB-1t2qH:
1.1		 4f8hA-1t2qH:
18.18
4f8hB-1t2qH:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 1t2q FAB NNA7 LIGHT CHAIN
(Mus
musculus) 		4 / 8 TYR H  94
ASP H  89
PHE H  64
LEU H  49
 None
 0.86A 4f8hB-1t2qH:
1.2
4f8hC-1t2qH:
1.2		 4f8hB-1t2qH:
18.18
4f8hC-1t2qH:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 1t2q FAB NNA7 LIGHT CHAIN
(Mus
musculus) 		4 / 8 TYR H  94
ASP H  89
PHE H  64
LEU H  49
 None
 0.82A 4f8hC-1t2qH:
1.2
4f8hD-1t2qH:
1.2		 4f8hC-1t2qH:
18.18
4f8hD-1t2qH:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 1t2q FAB NNA7 LIGHT CHAIN
(Mus
musculus) 		4 / 8 TYR H  94
ASP H  89
PHE H  64
LEU H  49
 None
 0.83A 4f8hD-1t2qH:
1.2
4f8hE-1t2qH:
1.1		 4f8hD-1t2qH:
18.18
4f8hE-1t2qH:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 1t2q FAB NNA7 LIGHT CHAIN
(Mus
musculus) 		4 / 8 PHE H  64
LEU H  49
TYR H  94
ASP H  89
 None
 0.84A 4f8hA-1t2qH:
1.1
4f8hE-1t2qH:
1.2		 4f8hA-1t2qH:
18.18
4f8hE-1t2qH:
18.18