SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t2w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 1t2w SORTASE
(Staphylococcus
aureus) 		3 / 3 GLU A 105
ALA A  92
SER A 102
 GLU  A 333 (-3.2A)
GLY  A 335 (-3.0A)
None
 0.53A 1errB-1t2wA:
undetectable		 1errB-1t2wA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 1t2w SORTASE
(Staphylococcus
aureus) 		4 / 6 TYR A 153
VAL A  87
ILE A  83
ARG A 197
 None
None
None
GLU  A 333 ( 3.8A)
 0.92A 3pyyA-1t2wA:
undetectable		 3pyyA-1t2wA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 1t2w SORTASE
(Staphylococcus
aureus) 		4 / 7 TRP A 194
PRO A  94
GLY A  90
PRO A  89
 GLY  A 335 (-4.4A)
None
None
None
 1.39A 3ucbB-1t2wA:
undetectable		 3ucbB-1t2wA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 1t2w SORTASE
(Staphylococcus
aureus) 		4 / 4 LEU A  97
ILE A 117
GLY A 100
PHE A 130
 None
 1.10A 4dc3A-1t2wA:
undetectable		 4dc3A-1t2wA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 1t2w SORTASE
(Staphylococcus
aureus) 		4 / 7 ILE A  65
LEU A 110
ALA A  73
VAL A  72
 None
 0.73A 4g77A-1t2wA:
undetectable		 4g77A-1t2wA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 1t2w SORTASE
(Staphylococcus
aureus) 		5 / 12 TYR A 187
GLY A  90
GLU A 106
ALA A 184
HIS A 120
 None
None
None
THR  A 334 ( 4.6A)
None
 1.12A 4wcxC-1t2wA:
undetectable		 4wcxC-1t2wA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1t2w SORTASE
(Staphylococcus
aureus) 		4 / 5 ALA A 202
TYR A 153
GLN A 178
ILE A 115
 None
 1.22A 6f6sA-1t2wA:
0.0
6f6sB-1t2wA:
0.0		 6f6sA-1t2wA:
18.79
6f6sB-1t2wA:
20.13