SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t33'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1t33 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR (TETR/ACRR
FAMILY)
(Salmonella
enterica) 		4 / 8 LEU A 173
LEU A 144
ILE A 141
HIS A 145
 None
 0.93A 2azxA-1t33A:
undetectable		 2azxA-1t33A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1t33 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR (TETR/ACRR
FAMILY)
(Salmonella
enterica) 		4 / 7 LEU A  70
PHE A  69
THR A 111
LEU A 110
 None
 0.97A 2eikA-1t33A:
0.0
2eikJ-1t33A:
undetectable		 2eikA-1t33A:
17.32
2eikJ-1t33A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 1t33 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR (TETR/ACRR
FAMILY)
(Salmonella
enterica) 		4 / 7 ILE A  95
ILE A 214
LEU A 172
ILE A 211
 None
 0.86A 2q83A-1t33A:
undetectable		 2q83A-1t33A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 1t33 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR (TETR/ACRR
FAMILY)
(Salmonella
enterica) 		5 / 12 LEU A  22
ALA A  20
GLY A  26
ILE A  18
LEU A  58
 None
 1.18A 3gyqA-1t33A:
undetectable
3gyqB-1t33A:
undetectable		 3gyqA-1t33A:
22.18
3gyqB-1t33A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 1t33 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR (TETR/ACRR
FAMILY)
(Salmonella
enterica) 		5 / 11 LEU A  22
ALA A  20
GLY A  26
ILE A  18
LEU A  58
 None
 1.20A 3gyqB-1t33A:
undetectable		 3gyqB-1t33A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1t33 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR (TETR/ACRR
FAMILY)
(Salmonella
enterica) 		4 / 8 LEU A 110
LYS A 183
VAL A 116
LEU A 177
 None
 1.08A 3v81A-1t33A:
undetectable		 3v81A-1t33A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1t33 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR (TETR/ACRR
FAMILY)
(Salmonella
enterica) 		5 / 10 VAL A 176
VAL A 207
ILE A 211
LEU A 144
LEU A 148
 None
 1.25A 4jtqA-1t33A:
undetectable		 4jtqA-1t33A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1t33 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR (TETR/ACRR
FAMILY)
(Salmonella
enterica) 		5 / 7 LEU A 215
THR A 169
LEU A 172
THR A 149
THR A 156
 None
 1.48A 4z90A-1t33A:
3.4
4z90B-1t33A:
3.1
4z90C-1t33A:
3.5
4z90D-1t33A:
3.5
4z90E-1t33A:
3.5		 4z90A-1t33A:
21.73
4z90B-1t33A:
21.73
4z90C-1t33A:
21.73
4z90D-1t33A:
21.73
4z90E-1t33A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 1t33 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR (TETR/ACRR
FAMILY)
(Salmonella
enterica) 		4 / 4 LEU A 100
MET A 106
ILE A  95
LEU A 148
 None
 1.31A 5nfpA-1t33A:
0.0		 5nfpA-1t33A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1t33 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR (TETR/ACRR
FAMILY)
(Salmonella
enterica) 		4 / 6 LEU A 148
VAL A 152
THR A 156
LEU A 173
 None
 0.85A 5tudD-1t33A:
3.2		 5tudD-1t33A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1t33 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR (TETR/ACRR
FAMILY)
(Salmonella
enterica) 		4 / 7 ASP A  93
ARG A  96
TYR A 155
ASP A 212
 None
 1.10A 6mn5E-1t33A:
0.0		 6mn5E-1t33A:
17.37