SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t34'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1t34 ATRIAL NATRIURETIC
PEPTIDE RECEPTOR A
(Rattus
norvegicus) 		4 / 6 VAL A  93
GLY A  94
LEU A 104
TYR A 120
 None
 0.76A 1fduD-1t34A:
6.0		 1fduD-1t34A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 1t34 ATRIAL NATRIURETIC
PEPTIDE RECEPTOR A
(Rattus
norvegicus) 		4 / 7 PRO A 103
VAL A  80
LEU A 105
THR A 124
 None
 0.93A 1jgsA-1t34A:
undetectable		 1jgsA-1t34A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 1t34 ATRIAL NATRIURETIC
PEPTIDE RECEPTOR A
(Rattus
norvegicus) 		4 / 4 HIS A 148
VAL A 420
THR A 182
LEU A 151
 None
 1.18A 1oq5A-1t34A:
undetectable		 1oq5A-1t34A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 1t34 ATRIAL NATRIURETIC
PEPTIDE RECEPTOR A
(Rattus
norvegicus) 		5 / 12 THR A  97
ALA A   6
ALA A  68
GLY A  85
PRO A  92
 None
None
None
CL  A 600 (-3.9A)
None
 1.20A 2ve3B-1t34A:
undetectable		 2ve3B-1t34A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1t34 ATRIAL NATRIURETIC
PEPTIDE RECEPTOR A
(Rattus
norvegicus) 		4 / 7 ALA A 111
ALA A 109
THR A 106
LEU A 104
 None
 0.90A 2wx2A-1t34A:
undetectable		 2wx2A-1t34A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 1t34 ATRIAL NATRIURETIC
PEPTIDE RECEPTOR A
(Rattus
norvegicus) 		3 / 3 ASP A  39
THR A 349
GLU A 334
 None
 0.84A 2zifB-1t34A:
undetectable		 2zifB-1t34A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 1t34 ATRIAL NATRIURETIC
PEPTIDE RECEPTOR A
(Rattus
norvegicus) 		4 / 8 LEU A 378
ILE A 280
TYR A 211
GLY A 134
 None
 0.90A 3b9lA-1t34A:
undetectable		 3b9lA-1t34A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 1t34 ATRIAL NATRIURETIC
PEPTIDE RECEPTOR A
(Rattus
norvegicus) 		4 / 8 ALA A 111
ALA A 109
THR A 106
LEU A 104
 None
 0.87A 3khmA-1t34A:
undetectable		 3khmA-1t34A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 1t34 ATRIAL NATRIURETIC
PEPTIDE RECEPTOR A
(Rattus
norvegicus) 		4 / 8 LEU A 144
ALA A 403
GLY A 414
PRO A 416
 None
 0.94A 3ny4A-1t34A:
undetectable		 3ny4A-1t34A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1t34 ATRIAL NATRIURETIC
PEPTIDE RECEPTOR A
(Rattus
norvegicus) 		5 / 12 LEU A 151
VAL A 203
ALA A 277
PHE A 219
PHE A 188
 None
 1.40A 4iaqA-1t34A:
undetectable		 4iaqA-1t34A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1t34 ATRIAL NATRIURETIC
PEPTIDE RECEPTOR A
(Rattus
norvegicus) 		4 / 6 VAL A 209
TYR A 211
TRP A 146
HIS A 141
 None
 1.32A 4jtrB-1t34A:
undetectable		 4jtrB-1t34A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 1t34 ATRIAL NATRIURETIC
PEPTIDE RECEPTOR A
(Rattus
norvegicus) 		5 / 12 GLY A 245
PHE A 274
PHE A 388
ILE A 279
PHE A 219
 None
 1.28A 4wh5A-1t34A:
0.0		 4wh5A-1t34A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1t34 ATRIAL NATRIURETIC
PEPTIDE RECEPTOR A
(Rattus
norvegicus) 		3 / 3 PHE A 388
ASP A 382
LEU A 254
 None
 0.77A 5uhbC-1t34A:
1.2		 5uhbC-1t34A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1t34 ATRIAL NATRIURETIC
PEPTIDE RECEPTOR A
(Rattus
norvegicus) 		3 / 3 PHE A 388
ASP A 382
LEU A 254
 None
 0.78A 5uhcC-1t34A:
undetectable		 5uhcC-1t34A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1t34 ATRIAL NATRIURETIC
PEPTIDE RECEPTOR A
(Rattus
norvegicus) 		4 / 5 VAL A  93
THR A  97
VAL A  23
LEU A  50
 None
 1.00A 6bqgA-1t34A:
undetectable		 6bqgA-1t34A:
10.05