SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t3d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1t3d SERINE
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 182
GLY A 217
GLY A 215
ILE A 202
LEU A 111
 None
 1.02A 1p91B-1t3dA:
undetectable		 1p91B-1t3dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1t3d SERINE
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 ILE A 170
VAL A 180
ALA A 206
ILE A 220
MET A 201
 None
 1.04A 2h42B-1t3dA:
undetectable		 2h42B-1t3dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1t3d SERINE
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 7 VAL A 142
ILE A 144
ALA A 113
VAL A 136
GLY A 107
 None
 1.46A 2xrzB-1t3dA:
undetectable		 2xrzB-1t3dA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 1t3d SERINE
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 10 GLY A 165
ALA A 168
ILE A 154
LEU A 156
ILE A 176
 None
 1.02A 4dt8B-1t3dA:
undetectable		 4dt8B-1t3dA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1t3d SERINE
ACETYLTRANSFERASE
(Escherichia
coli) 		4 / 4 ALA A  94
VAL A  95
ASP A  92
LEU A 105
 None
 0.97A 4e7gA-1t3dA:
undetectable		 4e7gA-1t3dA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1t3d SERINE
ACETYLTRANSFERASE
(Escherichia
coli) 		4 / 4 ASN A 261
GLY A 262
ASP A 157
ASP A 257
 None
 1.28A 4n49A-1t3dA:
undetectable		 4n49A-1t3dA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 1t3d SERINE
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 156
ILE A 202
ILE A 208
GLY A 183
ILE A 176
 None
 0.93A 4q1yB-1t3dA:
undetectable		 4q1yB-1t3dA:
17.56