SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t3h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 1t3h DEPHOSPHO-COA KINASE
(Escherichia
coli) 		5 / 9 ASP A 185
ASP A 131
VAL A 130
GLY A 177
ILE A 173
 None
 1.13A 1hpvB-1t3hA:
undetectable		 1hpvB-1t3hA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1t3h DEPHOSPHO-COA KINASE
(Escherichia
coli) 		5 / 12 GLY A   9
VAL A 132
GLY A  12
LEU A 156
ILE A  11
 None
None
SO4  A 301 (-3.2A)
None
None
 1.17A 3ku1G-1t3hA:
undetectable		 3ku1G-1t3hA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1t3h DEPHOSPHO-COA KINASE
(Escherichia
coli) 		5 / 12 ILE A  92
ALA A  46
LEU A  88
LEU A  84
ILE A  50
 None
 1.08A 3uvvA-1t3hA:
1.2		 3uvvA-1t3hA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 1t3h DEPHOSPHO-COA KINASE
(Escherichia
coli) 		4 / 5 VAL A  18
LEU A 128
VAL A   5
PHE A  22
 None
 1.01A 4lb0B-1t3hA:
undetectable		 4lb0B-1t3hA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1t3h DEPHOSPHO-COA KINASE
(Escherichia
coli) 		5 / 8 ASP A 131
VAL A 129
GLY A  12
PRO A 113
VAL A 111
 None
None
SO4  A 301 (-3.2A)
None
None
 1.38A 4ll3A-1t3hA:
undetectable		 4ll3A-1t3hA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1t3h DEPHOSPHO-COA KINASE
(Escherichia
coli) 		5 / 8 ASP A 185
ASP A 131
VAL A 130
GLY A 177
ILE A 173
 None
 1.22A 4ll3A-1t3hA:
undetectable		 4ll3A-1t3hA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 1t3h DEPHOSPHO-COA KINASE
(Escherichia
coli) 		5 / 9 ASP A 185
ASP A 131
VAL A 130
GLY A 177
ILE A 173
 None
 1.20A 4ll3B-1t3hA:
undetectable		 4ll3B-1t3hA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 1t3h DEPHOSPHO-COA KINASE
(Escherichia
coli) 		3 / 3 VAL A 132
SER A 133
THR A 136
 None
 0.43A 4luhA-1t3hA:
undetectable		 4luhA-1t3hA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1t3h DEPHOSPHO-COA KINASE
(Escherichia
coli) 		4 / 5 LEU A 115
ALA A  32
THR A  96
ILE A 100
 None
 0.90A 4xe3B-1t3hA:
undetectable		 4xe3B-1t3hA:
18.18