SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t44'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 1t44 CHIMERA OF GELSOLIN
DOMAIN 1 AND
C-TERMINAL DOMAIN OF
THYMOSIN BETA-4
(Homo
sapiens;
Mus
musculus) 		3 / 3 VAL G  69
VAL G  46
TRP G  44
 None
 0.70A 1av2C-1t44G:
undetectable
1av2D-1t44G:
undetectable		 1av2C-1t44G:
10.14
1av2D-1t44G:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1t44 CHIMERA OF GELSOLIN
DOMAIN 1 AND
C-TERMINAL DOMAIN OF
THYMOSIN BETA-4
(Homo
sapiens;
Mus
musculus) 		4 / 8 TYR G  59
LEU G  41
LEU G 138
TRP G  88
 None
 1.09A 1i7zA-1t44G:
undetectable		 1i7zA-1t44G:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 1t44 CHIMERA OF GELSOLIN
DOMAIN 1 AND
C-TERMINAL DOMAIN OF
THYMOSIN BETA-4
(Homo
sapiens;
Mus
musculus) 		3 / 3 VAL G  69
VAL G  46
TRP G  44
 None
 0.77A 1w5uC-1t44G:
undetectable
1w5uD-1t44G:
undetectable		 1w5uC-1t44G:
10.14
1w5uD-1t44G:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1t44 CHIMERA OF GELSOLIN
DOMAIN 1 AND
C-TERMINAL DOMAIN OF
THYMOSIN BETA-4
(Homo
sapiens;
Mus
musculus) 		4 / 4 HIS G  86
ASP G 109
ASN G 113
ASP G  84
 None
CA  G 701 (-2.3A)
None
None
 1.20A 1wg8A-1t44G:
undetectable		 1wg8A-1t44G:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 1t44 CHIMERA OF GELSOLIN
DOMAIN 1 AND
C-TERMINAL DOMAIN OF
THYMOSIN BETA-4
(Homo
sapiens;
Mus
musculus) 		3 / 3 VAL G  46
TRP G  44
VAL G  69
 None
 0.73A 2izqA-1t44G:
undetectable
2izqB-1t44G:
undetectable		 2izqA-1t44G:
10.14
2izqB-1t44G:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1t44 CHIMERA OF GELSOLIN
DOMAIN 1 AND
C-TERMINAL DOMAIN OF
THYMOSIN BETA-4
(Homo
sapiens;
Mus
musculus) 		4 / 5 LEU G  71
GLN G  82
THR G  73
THR G 105
 None
 1.05A 2zj0B-1t44G:
undetectable		 2zj0B-1t44G:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1t44 CHIMERA OF GELSOLIN
DOMAIN 1 AND
C-TERMINAL DOMAIN OF
THYMOSIN BETA-4
(Homo
sapiens;
Mus
musculus) 		4 / 5 LEU G  71
GLN G  82
THR G  73
THR G 105
 None
 1.00A 2zj0C-1t44G:
undetectable		 2zj0C-1t44G:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1t44 CHIMERA OF GELSOLIN
DOMAIN 1 AND
C-TERMINAL DOMAIN OF
THYMOSIN BETA-4
(Homo
sapiens;
Mus
musculus) 		4 / 4 LEU G  71
GLN G  82
THR G  73
THR G 105
 None
 1.05A 2zj0D-1t44G:
undetectable		 2zj0D-1t44G:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1t44 CHIMERA OF GELSOLIN
DOMAIN 1 AND
C-TERMINAL DOMAIN OF
THYMOSIN BETA-4
(Homo
sapiens;
Mus
musculus) 		4 / 5 LEU G  71
GLN G  82
THR G  73
THR G 105
 None
 1.03A 3ce6B-1t44G:
undetectable		 3ce6B-1t44G:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 1t44 CHIMERA OF GELSOLIN
DOMAIN 1 AND
C-TERMINAL DOMAIN OF
THYMOSIN BETA-4
(Homo
sapiens;
Mus
musculus) 		3 / 3 VAL G  69
VAL G  46
TRP G  44
 None
 0.81A 3l8lA-1t44G:
undetectable
3l8lB-1t44G:
undetectable		 3l8lA-1t44G:
10.14
3l8lB-1t44G:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1t44 CHIMERA OF GELSOLIN
DOMAIN 1 AND
C-TERMINAL DOMAIN OF
THYMOSIN BETA-4
(Homo
sapiens;
Mus
musculus) 		3 / 3 GLY G  90
THR G  64
ASN G  91
 None
 0.66A 3v4tD-1t44G:
undetectable		 3v4tD-1t44G:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1t44 CHIMERA OF GELSOLIN
DOMAIN 1 AND
C-TERMINAL DOMAIN OF
THYMOSIN BETA-4
(Homo
sapiens;
Mus
musculus) 		4 / 7 TYR G 133
ILE G  70
LEU G 138
GLY G  60
 None
 0.88A 4iqqB-1t44G:
undetectable		 4iqqB-1t44G:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1t44 CHIMERA OF GELSOLIN
DOMAIN 1 AND
C-TERMINAL DOMAIN OF
THYMOSIN BETA-4
(Homo
sapiens;
Mus
musculus) 		4 / 5 GLY G 148
ASP G  96
GLU G  47
VAL G  69
 None
 0.94A 4nkvD-1t44G:
undetectable		 4nkvD-1t44G:
16.74