SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t47'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		4 / 7 THR A 149
VAL A 192
GLY A 190
ILE A 244
 None
 0.74A 1gtnC-1t47A:
undetectable
1gtnD-1t47A:
undetectable		 1gtnC-1t47A:
12.47
1gtnD-1t47A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		5 / 10 PHE A 242
PHE A 210
ILE A 105
GLY A  22
ILE A 185
 None
 1.07A 1z11C-1t47A:
undetectable		 1z11C-1t47A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		5 / 10 PHE A 242
PHE A 210
ILE A 105
GLY A  22
ILE A 185
 None
 1.07A 1z11D-1t47A:
undetectable		 1z11D-1t47A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		5 / 10 ALA A 113
ALA A 115
ALA A 112
VAL A 107
ALA A 141
 None
 1.04A 2f16K-1t47A:
undetectable
2f16L-1t47A:
undetectable		 2f16K-1t47A:
22.08
2f16L-1t47A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		5 / 10 ALA A 113
ALA A 115
ALA A 112
VAL A 107
ALA A 141
 None
 1.04A 2f16Y-1t47A:
undetectable
2f16Z-1t47A:
undetectable		 2f16Y-1t47A:
22.08
2f16Z-1t47A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		5 / 11 VAL A 279
TYR A 331
ASP A 277
THR A 316
THR A 310
 None
 1.45A 2f9wA-1t47A:
undetectable
2f9wB-1t47A:
undetectable		 2f9wA-1t47A:
22.90
2f9wB-1t47A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		4 / 7 TYR A 225
GLY A 362
ASP A 325
ASP A 329
 None
 1.09A 2g72B-1t47A:
undetectable		 2g72B-1t47A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_H_CSCH1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		5 / 12 TYR A 163
PHE A 210
HIS A 151
ASP A 102
VAL A 100
 None
 1.13A 2vavH-1t47A:
undetectable		 2vavH-1t47A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_L_CSCL1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		5 / 12 TYR A 163
PHE A 210
HIS A 151
ASP A 102
VAL A 100
 None
 1.10A 2vavL-1t47A:
0.0		 2vavL-1t47A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		4 / 5 ALA A  29
ALA A  37
TYR A  39
MET A  46
 None
 1.15A 3d91A-1t47A:
0.1		 3d91A-1t47A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		4 / 7 THR A 281
ILE A 322
ILE A 335
THR A 275
 None
 0.70A 3deuA-1t47A:
undetectable		 3deuA-1t47A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		5 / 12 MET A 285
TYR A  39
ILE A 271
ILE A 351
ILE A 335
 None
 1.19A 3fpjB-1t47A:
undetectable		 3fpjB-1t47A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		4 / 7 PHE A  18
GLY A 209
PHE A 210
PHE A 242
 None
 1.08A 3ko0D-1t47A:
undetectable
3ko0E-1t47A:
0.0		 3ko0D-1t47A:
15.34
3ko0E-1t47A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		5 / 8 PHE A  18
GLY A 209
PHE A 210
ILE A 143
PHE A 242
 None
 1.21A 3ko0O-1t47A:
undetectable
3ko0Q-1t47A:
undetectable		 3ko0O-1t47A:
15.34
3ko0Q-1t47A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		5 / 12 LEU A 228
ASN A 191
VAL A 192
VAL A 189
GLY A 190
 None
 1.28A 3medA-1t47A:
undetectable
3medB-1t47A:
0.0		 3medA-1t47A:
21.11
3medB-1t47A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		3 / 3 ILE A 335
VAL A 282
ARG A 286
 None
 0.64A 3p73A-1t47A:
0.3		 3p73A-1t47A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		5 / 12 LEU A  89
GLY A  53
ASN A  56
THR A  76
GLY A 166
 None
 1.12A 3vaqB-1t47A:
undetectable		 3vaqB-1t47A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		3 / 3 TYR A 300
THR A 295
GLU A 319
 None
 0.79A 4df3A-1t47A:
undetectable		 4df3A-1t47A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		3 / 3 TYR A 300
THR A 295
GLU A 319
 None
 0.80A 4df3B-1t47A:
undetectable		 4df3B-1t47A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		4 / 4 ALA A 104
VAL A 154
ASP A  24
LEU A 164
 None
 1.08A 4e7gA-1t47A:
undetectable		 4e7gA-1t47A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		4 / 7 PRO A  54
SER A  63
ASP A  24
THR A 152
 None
 1.04A 4uacA-1t47A:
undetectable		 4uacA-1t47A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		3 / 5 GLY A 267
GLY A 265
GLU A 193
 None
 0.51A 4z2eA-1t47A:
undetectable
4z2eD-1t47A:
undetectable		 4z2eA-1t47A:
21.22
4z2eD-1t47A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		4 / 5 GLY A 158
TYR A 159
VAL A 154
ARG A 156
 None
 1.32A 5x80C-1t47A:
undetectable
5x80D-1t47A:
undetectable		 5x80C-1t47A:
20.42
5x80D-1t47A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		4 / 6 TYR A 204
VAL A 201
TYR A 146
ILE A 244
 None
 1.05A 5z3jA-1t47A:
undetectable		 5z3jA-1t47A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		5 / 8 GLY A 267
GLN A 269
VAL A  26
VAL A 346
LEU A 103
 None
NTD  A 551 ( 4.2A)
None
None
None
 1.42A 6czmD-1t47A:
undetectable
6czmF-1t47A:
undetectable		 6czmD-1t47A:
24.15
6czmF-1t47A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Streptomyces
avermitilis) 		5 / 12 ILE A 335
VAL A 282
THR A 281
ILE A 278
PHE A  44
 None
 1.20A 6hlpA-1t47A:
undetectable		 6hlpA-1t47A:
21.30