SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t4k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 1t4k IMMUNOGLOBULIN IGG1,
HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL B  24
THR B  23
ILE B  20
THR B  68
ILE B  69
 None
 1.19A 3ddyA-1t4kB:
undetectable		 3ddyA-1t4kB:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1t4k IMMUNOGLOBULIN IGG1,
HEAVY CHAIN
(Mus
musculus) 		4 / 5 TYR B  90
LEU B  80
LEU B  83
ARG B  66
 None
 1.18A 4em2A-1t4kB:
undetectable		 4em2A-1t4kB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 1t4k IMMUNOGLOBULIN IGG1,
HEAVY CHAIN
(Mus
musculus) 		5 / 9 TYR B  97
GLY B  98
GLY B  99
HIS B  95
ASP B 101
 None
 1.04A 5f8yA-1t4kB:
0.0		 5f8yA-1t4kB:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1t4k IMMUNOGLOBULIN IGG1,
HEAVY CHAIN
(Mus
musculus) 		5 / 8 ALA B  88
LEU B  18
LEU B  83
LEU B  48
LEU B  80
 None
 1.11A 5jqbA-1t4kB:
undetectable
5jqbB-1t4kB:
undetectable		 5jqbA-1t4kB:
21.66
5jqbB-1t4kB:
20.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 1t4k IMMUNOGLOBULIN IGG1,
HEAVY CHAIN
(Mus
musculus) 		5 / 5 SER B 112
ALA B 114
PHE B 148
LEU B 178
ASP B 183
 None
 0.42A 5mthA-1t4kB:
27.7		 5mthA-1t4kB:
68.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1t4k IMMUNOGLOBULIN IGG1,
HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR B  68
MET B  82
HIS B  83
 None
None
ZN  B 308 (-3.2A)
 0.68A 5uunA-1t4kB:
undetectable		 5uunA-1t4kB:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1t4k IMMUNOGLOBULIN IGG1,
HEAVY CHAIN
(Mus
musculus) 		4 / 5 VAL B 109
THR B 107
LEU B  83
LEU B  63
 None
 1.02A 6bqgA-1t4kB:
undetectable		 6bqgA-1t4kB:
14.88