SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t4n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 1t4n RIBONUCLEASE III
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 443
ALA A 446
LEU A 377
SER A 376
 None
 0.99A 1ictB-1t4nA:
undetectable		 1ictB-1t4nA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 1t4n RIBONUCLEASE III
(Saccharomyces
cerevisiae) 		4 / 5 LYS A 443
ALA A 446
LEU A 377
SER A 376
 None
 1.07A 1tt6B-1t4nA:
undetectable		 1tt6B-1t4nA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 1t4n RIBONUCLEASE III
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 443
ALA A 446
LEU A 377
SER A 376
 None
 0.98A 1tyrA-1t4nA:
undetectable		 1tyrA-1t4nA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 1t4n RIBONUCLEASE III
(Saccharomyces
cerevisiae) 		4 / 7 LYS A 443
ALA A 446
LEU A 377
SER A 376
 None
 0.87A 1tyrB-1t4nA:
undetectable		 1tyrB-1t4nA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 1t4n RIBONUCLEASE III
(Saccharomyces
cerevisiae) 		4 / 7 LYS A 443
ALA A 446
LEU A 377
SER A 376
 None
 0.95A 3d2tA-1t4nA:
undetectable		 3d2tA-1t4nA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 1t4n RIBONUCLEASE III
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 443
ALA A 446
LEU A 377
SER A 376
 None
 0.96A 3d2tB-1t4nA:
undetectable		 3d2tB-1t4nA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 1t4n RIBONUCLEASE III
(Saccharomyces
cerevisiae) 		4 / 7 LYS A 443
ALA A 446
LEU A 377
SER A 376
 None
 1.02A 3ozkB-1t4nA:
undetectable		 3ozkB-1t4nA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 1t4n RIBONUCLEASE III
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 427
ILE A 401
GLY A 417
ILE A 422
LEU A 366
 None
 1.02A 3u7sA-1t4nA:
undetectable		 3u7sA-1t4nA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 1t4n RIBONUCLEASE III
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 443
ALA A 446
LEU A 377
SER A 376
 None
 0.99A 4d7bB-1t4nA:
undetectable		 4d7bB-1t4nA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 1t4n RIBONUCLEASE III
(Saccharomyces
cerevisiae) 		4 / 7 LYS A 443
ALA A 446
LEU A 377
SER A 376
 None
 0.97A 4d7bA-1t4nA:
undetectable		 4d7bA-1t4nA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 1t4n RIBONUCLEASE III
(Saccharomyces
cerevisiae) 		4 / 7 LYS A 443
ALA A 446
LEU A 377
SER A 376
 None
 0.99A 4ikjA-1t4nA:
undetectable
4ikjB-1t4nA:
undetectable		 4ikjA-1t4nA:
22.88
4ikjB-1t4nA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 1t4n RIBONUCLEASE III
(Saccharomyces
cerevisiae) 		4 / 7 LYS A 443
ALA A 446
LEU A 377
SER A 376
 None
 0.97A 4iklA-1t4nA:
undetectable
4iklB-1t4nA:
undetectable		 4iklA-1t4nA:
22.88
4iklB-1t4nA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 1t4n RIBONUCLEASE III
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 421
GLY A 424
TYR A 387
ALA A 428
 None
 1.19A 4yshB-1t4nA:
undetectable		 4yshB-1t4nA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 1t4n RIBONUCLEASE III
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 443
ALA A 446
LEU A 377
SER A 376
 None
 0.78A 5a6iA-1t4nA:
undetectable		 5a6iA-1t4nA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 1t4n RIBONUCLEASE III
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 443
ALA A 446
LEU A 377
SER A 376
 None
 1.00A 5bojA-1t4nA:
undetectable		 5bojA-1t4nA:
22.88