SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t4o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 1t4o RIBONUCLEASE III
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 430
GLY A 424
GLY A 415
LEU A 432
ALA A 370
 None
 0.81A 2egvA-1t4oA:
undetectable		 2egvA-1t4oA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 1t4o RIBONUCLEASE III
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 430
GLY A 424
GLY A 415
LEU A 432
ALA A 370
 None
 0.87A 2egvB-1t4oA:
undetectable		 2egvB-1t4oA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 1t4o RIBONUCLEASE III
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 405
ILE A 420
THR A 394
 None
 0.74A 3ia4D-1t4oA:
undetectable		 3ia4D-1t4oA:
20.00