SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t4w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1t4w C.ELEGANS P53 TUMOR
SUPPRESSOR-LIKE
TRANSCRIPTION FACTOR
(Caenorhabditis
elegans) 		4 / 8 PHE A 355
ILE A 325
PHE A 323
PHE A 359
 None
 0.86A 1fslA-1t4wA:
undetectable		 1fslA-1t4wA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 1t4w C.ELEGANS P53 TUMOR
SUPPRESSOR-LIKE
TRANSCRIPTION FACTOR
(Caenorhabditis
elegans) 		4 / 8 PHE A 355
ILE A 325
PHE A 323
PHE A 359
 None
 0.79A 1fslB-1t4wA:
undetectable		 1fslB-1t4wA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 1t4w C.ELEGANS P53 TUMOR
SUPPRESSOR-LIKE
TRANSCRIPTION FACTOR
(Caenorhabditis
elegans) 		4 / 8 SER A 335
THR A 341
ASP A 303
LYS A 286
 None
 1.15A 1mxgA-1t4wA:
undetectable		 1mxgA-1t4wA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 1t4w C.ELEGANS P53 TUMOR
SUPPRESSOR-LIKE
TRANSCRIPTION FACTOR
(Caenorhabditis
elegans) 		5 / 12 LEU A 381
ALA A 353
ILE A 282
ILE A 325
ILE A 345
 None
 0.96A 2o4nA-1t4wA:
undetectable		 2o4nA-1t4wA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 1t4w C.ELEGANS P53 TUMOR
SUPPRESSOR-LIKE
TRANSCRIPTION FACTOR
(Caenorhabditis
elegans) 		3 / 3 ASP A 320
PHE A 317
SER A 335
 None
 0.96A 3i5uB-1t4wA:
undetectable		 3i5uB-1t4wA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 1t4w C.ELEGANS P53 TUMOR
SUPPRESSOR-LIKE
TRANSCRIPTION FACTOR
(Caenorhabditis
elegans) 		5 / 12 LEU A 366
CYH A 365
THR A 255
ILE A 399
PHE A 284
 None
ZN  A 201 (-2.4A)
None
None
None
 1.04A 3vw1D-1t4wA:
undetectable		 3vw1D-1t4wA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 1t4w C.ELEGANS P53 TUMOR
SUPPRESSOR-LIKE
TRANSCRIPTION FACTOR
(Caenorhabditis
elegans) 		3 / 3 TYR A 402
GLN A 362
TRP A 254
 None
 1.00A 4kn2C-1t4wA:
undetectable		 4kn2C-1t4wA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1t4w C.ELEGANS P53 TUMOR
SUPPRESSOR-LIKE
TRANSCRIPTION FACTOR
(Caenorhabditis
elegans) 		3 / 3 LEU A 344
ASP A 382
ILE A 357
 None
 0.71A 4xi3D-1t4wA:
undetectable		 4xi3D-1t4wA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 1t4w C.ELEGANS P53 TUMOR
SUPPRESSOR-LIKE
TRANSCRIPTION FACTOR
(Caenorhabditis
elegans) 		4 / 7 PHE A 323
ILE A 357
GLY A 258
PHE A 359
 None
 0.84A 5h3aA-1t4wA:
undetectable		 5h3aA-1t4wA:
20.64