SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t57'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 1t57 CONSERVED PROTEIN
MTH1675
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 175
ILE A 132
ALA A 133
ALA A 137
VAL A  36
 None
 1.03A 1cbsA-1t57A:
undetectable		 1cbsA-1t57A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1t57 CONSERVED PROTEIN
MTH1675
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 VAL A  37
ALA A  38
HIS A  61
 None
FMN  A 200 (-3.7A)
FMN  A 200 (-4.2A)
 0.71A 1q23C-1t57A:
undetectable		 1q23C-1t57A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1t57 CONSERVED PROTEIN
MTH1675
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 VAL A  37
ALA A  38
HIS A  61
 None
FMN  A 200 (-3.7A)
FMN  A 200 (-4.2A)
 0.60A 1q23H-1t57A:
undetectable		 1q23H-1t57A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1t57 CONSERVED PROTEIN
MTH1675
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 VAL A  37
ALA A  38
HIS A  61
 None
FMN  A 200 (-3.7A)
FMN  A 200 (-4.2A)
 0.65A 1q23G-1t57A:
undetectable		 1q23G-1t57A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1t57 CONSERVED PROTEIN
MTH1675
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 VAL A  37
ALA A  38
HIS A  61
 None
FMN  A 200 (-3.7A)
FMN  A 200 (-4.2A)
 0.62A 1q23J-1t57A:
undetectable		 1q23J-1t57A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 1t57 CONSERVED PROTEIN
MTH1675
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 175
ILE A 132
ALA A 133
ALA A 137
VAL A  36
 None
 1.01A 2fr3A-1t57A:
undetectable		 2fr3A-1t57A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 1t57 CONSERVED PROTEIN
MTH1675
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A  20
GLY A 157
GLY A 125
VAL A  23
VAL A  19
 None
FMN  A 200 (-3.1A)
None
None
None
 0.87A 2nnkA-1t57A:
undetectable		 2nnkA-1t57A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 1t57 CONSERVED PROTEIN
MTH1675
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A  20
GLY A 157
GLY A 125
VAL A  23
VAL A  19
 None
FMN  A 200 (-3.1A)
None
None
None
 0.93A 2nnkB-1t57A:
undetectable		 2nnkB-1t57A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1t57 CONSERVED PROTEIN
MTH1675
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 HIS A  61
HIS A  93
HIS A  62
 FMN  A 200 (-4.2A)
FMN  A 200 (-3.3A)
None
 0.68A 2zxwA-1t57A:
undetectable		 2zxwA-1t57A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1t57 CONSERVED PROTEIN
MTH1675
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 HIS A  61
HIS A  93
HIS A  62
 FMN  A 200 (-4.2A)
FMN  A 200 (-3.3A)
None
 0.71A 3abmN-1t57A:
undetectable		 3abmN-1t57A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 1t57 CONSERVED PROTEIN
MTH1675
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 ILE A  56
ALA A  45
LEU A  48
ILE A 151
 None
 0.68A 5mvmB-1t57A:
undetectable
5mvmC-1t57A:
undetectable		 5mvmB-1t57A:
17.50
5mvmC-1t57A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 1t57 CONSERVED PROTEIN
MTH1675
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 GLU A  14
GLY A 152
ALA A 158
PRO A 184
VAL A 128
 None
FMN  A 200 ( 4.2A)
None
None
FMN  A 200 (-4.6A)
 1.18A 5yk2A-1t57A:
undetectable		 5yk2A-1t57A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1t57 CONSERVED PROTEIN
MTH1675
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 HIS A  61
HIS A  93
HIS A  62
 FMN  A 200 (-4.2A)
FMN  A 200 (-3.3A)
None
 0.73A 6nknA-1t57A:
undetectable		 6nknA-1t57A:
17.58