SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t5b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 1t5b ACYL CARRIER PROTEIN
PHOSPHODIESTERASE
(Salmonella
enterica) 		5 / 12 LEU A 138
LEU A   5
PHE A 109
LEU A 161
ALA A  94
 None
 1.10A 1bzfA-1t5bA:
undetectable		 1bzfA-1t5bA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 1t5b ACYL CARRIER PROTEIN
PHOSPHODIESTERASE
(Salmonella
enterica) 		6 / 9 LEU A   5
ALA A 135
ASP A 168
GLY A 165
ILE A 164
ILE A  90
 None
 1.49A 2idwB-1t5bA:
undetectable		 2idwB-1t5bA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1t5b ACYL CARRIER PROTEIN
PHOSPHODIESTERASE
(Salmonella
enterica) 		3 / 3 LEU A 105
LEU A   5
PHE A 109
 None
 0.69A 2pgrA-1t5bA:
undetectable		 2pgrA-1t5bA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1t5b ACYL CARRIER PROTEIN
PHOSPHODIESTERASE
(Salmonella
enterica) 		3 / 3 GLY A 128
GLY A 162
GLY A 165
 None
 0.39A 3bogC-1t5bA:
undetectable		 3bogC-1t5bA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1t5b ACYL CARRIER PROTEIN
PHOSPHODIESTERASE
(Salmonella
enterica) 		3 / 3 GLY A 128
GLY A 162
GLY A 165
 None
 0.30A 3bogD-1t5bA:
undetectable		 3bogD-1t5bA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1t5b ACYL CARRIER PROTEIN
PHOSPHODIESTERASE
(Salmonella
enterica) 		5 / 12 ILE A 112
PHE A 109
VAL A 130
ILE A 166
LEU A   5
 None
 0.98A 3oapA-1t5bA:
undetectable		 3oapA-1t5bA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 1t5b ACYL CARRIER PROTEIN
PHOSPHODIESTERASE
(Salmonella
enterica) 		5 / 12 LEU A  21
ILE A 177
ILE A 195
ALA A 193
ASP A 190
 None
FMN  A 202 ( 4.1A)
None
None
None
 1.17A 3vw1D-1t5bA:
undetectable		 3vw1D-1t5bA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1t5b ACYL CARRIER PROTEIN
PHOSPHODIESTERASE
(Salmonella
enterica) 		5 / 7 GLY A  19
THR A  22
VAL A   6
ILE A  92
VAL A  91
 None
 1.39A 5ik1A-1t5bA:
undetectable		 5ik1A-1t5bA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 1t5b ACYL CARRIER PROTEIN
PHOSPHODIESTERASE
(Salmonella
enterica) 		5 / 9 ILE A  92
ALA A 135
ILE A  90
ILE A 164
LEU A  84
 None
 0.86A 5mvmA-1t5bA:
undetectable
5mvmE-1t5bA:
undetectable		 5mvmA-1t5bA:
19.34
5mvmE-1t5bA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 1t5b ACYL CARRIER PROTEIN
PHOSPHODIESTERASE
(Salmonella
enterica) 		5 / 10 ILE A 164
LEU A  84
ILE A  92
ALA A 135
ILE A  90
 None
 0.88A 5mvmD-1t5bA:
undetectable
5mvmE-1t5bA:
undetectable		 5mvmD-1t5bA:
19.34
5mvmE-1t5bA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 1t5b ACYL CARRIER PROTEIN
PHOSPHODIESTERASE
(Salmonella
enterica) 		6 / 12 LEU A   5
ALA A 135
ASP A 168
GLY A 165
ILE A 164
ILE A  90
 None
 1.49A 5t2zB-1t5bA:
undetectable		 5t2zB-1t5bA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 1t5b ACYL CARRIER PROTEIN
PHOSPHODIESTERASE
(Salmonella
enterica) 		5 / 12 PHE A 109
ILE A 112
ILE A 164
ILE A  90
LEU A 161
 None
 0.96A 5uvmB-1t5bA:
undetectable		 5uvmB-1t5bA:
25.00