SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 1t5c CENTROMERIC PROTEIN
E
(Homo
sapiens) 		4 / 7 GLN A 115
ASP A 112
LEU A 211
SER A 175
 None
 1.08A 1ig3A-1t5cA:
undetectable
1ig3B-1t5cA:
undetectable		 1ig3A-1t5cA:
19.78
1ig3B-1t5cA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1t5c CENTROMERIC PROTEIN
E
(Homo
sapiens) 		4 / 7 TYR A 283
THR A  81
THR A 302
VAL A 268
 None
 1.02A 1tv8A-1t5cA:
undetectable		 1tv8A-1t5cA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 1t5c CENTROMERIC PROTEIN
E
(Homo
sapiens) 		4 / 6 LEU A 292
LEU A 272
LEU A 265
ILE A 281
 None
 0.87A 1z95A-1t5cA:
undetectable		 1z95A-1t5cA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1t5c CENTROMERIC PROTEIN
E
(Homo
sapiens) 		4 / 8 TYR A 283
THR A  81
THR A 302
VAL A 268
 None
 1.02A 2fb2A-1t5cA:
undetectable		 2fb2A-1t5cA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1t5c CENTROMERIC PROTEIN
E
(Homo
sapiens) 		4 / 7 TYR A 283
THR A  81
THR A 302
VAL A 268
 None
 1.07A 2fb2B-1t5cA:
undetectable		 2fb2B-1t5cA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 1t5c CENTROMERIC PROTEIN
E
(Homo
sapiens) 		5 / 12 LEU A 272
ALA A 300
ALA A   8
VAL A   9
THR A 289
 None
 1.15A 3c6gB-1t5cA:
0.0		 3c6gB-1t5cA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 1t5c CENTROMERIC PROTEIN
E
(Homo
sapiens) 		5 / 12 LEU A 272
ALA A 300
ALA A   8
VAL A   9
THR A 289
 None
 1.16A 3czhB-1t5cA:
undetectable		 3czhB-1t5cA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 1t5c CENTROMERIC PROTEIN
E
(Homo
sapiens) 		5 / 12 ALA A  67
LEU A 233
HIS A 111
LEU A 127
ALA A  74
 None
 1.12A 3dfrA-1t5cA:
undetectable		 3dfrA-1t5cA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 1t5c CENTROMERIC PROTEIN
E
(Homo
sapiens) 		4 / 8 THR A 205
LEU A 143
LEU A 142
GLY A 185
 None
 0.73A 4c9nA-1t5cA:
undetectable		 4c9nA-1t5cA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 1t5c CENTROMERIC PROTEIN
E
(Homo
sapiens) 		4 / 6 LEU A 292
LEU A 296
ILE A 269
THR A 302
 None
 0.94A 4do3B-1t5cA:
undetectable		 4do3B-1t5cA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 1t5c CENTROMERIC PROTEIN
E
(Homo
sapiens) 		5 / 12 LEU A  16
VAL A  29
PRO A 310
THR A 309
GLY A  86
 None
 1.34A 4q15B-1t5cA:
undetectable		 4q15B-1t5cA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1t5c CENTROMERIC PROTEIN
E
(Homo
sapiens) 		5 / 12 LEU A 167
LEU A 296
ARG A 208
ILE A 206
LEU A 265
 None
 1.12A 5ljeA-1t5cA:
undetectable		 5ljeA-1t5cA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 1t5c CENTROMERIC PROTEIN
E
(Homo
sapiens) 		4 / 6 TYR A  94
VAL A 105
VAL A  62
THR A  59
 ADP  A 600 (-3.5A)
None
None
None
 1.16A 6f32B-1t5cA:
undetectable		 6f32B-1t5cA:
19.21