SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t5e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 1t5e MULTIDRUG RESISTANCE
PROTEIN MEXA
(Pseudomonas
aeruginosa) 		4 / 4 ALA A  94
ARG A  96
GLN A  91
GLU A  92
 None
 1.28A 1lquB-1t5eA:
undetectable		 1lquB-1t5eA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1t5e MULTIDRUG RESISTANCE
PROTEIN MEXA
(Pseudomonas
aeruginosa) 		3 / 3 THR A  29
LEU A 259
VAL A 206
 None
 0.61A 1mz9E-1t5eA:
undetectable		 1mz9E-1t5eA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1t5e MULTIDRUG RESISTANCE
PROTEIN MEXA
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 208
GLN A 168
ILE A 173
PHE A 242
 None
 0.83A 2jn3A-1t5eA:
undetectable		 2jn3A-1t5eA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1t5e MULTIDRUG RESISTANCE
PROTEIN MEXA
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 254
GLY A  33
VAL A 175
LEU A 208
 None
 0.89A 3bgdB-1t5eA:
undetectable		 3bgdB-1t5eA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 1t5e MULTIDRUG RESISTANCE
PROTEIN MEXA
(Pseudomonas
aeruginosa) 		3 / 3 GLY A 143
ASP A  61
SER A  60
 None
 0.71A 3brfA-1t5eA:
undetectable		 3brfA-1t5eA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1t5e MULTIDRUG RESISTANCE
PROTEIN MEXA
(Pseudomonas
aeruginosa) 		5 / 7 LEU A 249
ASN A 244
VAL A 241
ILE A 141
THR A  35
 None
 1.45A 4eyrA-1t5eA:
undetectable		 4eyrA-1t5eA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1t5e MULTIDRUG RESISTANCE
PROTEIN MEXA
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 255
ARG A  39
PRO A 172
 None
 0.69A 5koxA-1t5eA:
undetectable		 5koxA-1t5eA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 1t5e MULTIDRUG RESISTANCE
PROTEIN MEXA
(Pseudomonas
aeruginosa) 		5 / 9 ILE A 141
ALA A  64
GLY A  65
LEU A 138
ARG A  39
 None
 1.28A 6nm4B-1t5eA:
undetectable		 6nm4B-1t5eA:
19.72