SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t5i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 1t5i C_TERMINAL DOMAIN OF
A PROBABLE
ATP-DEPENDENT RNA
HELICASE
(Homo
sapiens) 		4 / 5 ILE A 411
ILE A 399
TYR A 371
GLU A 366
 None
 1.22A 4a99D-1t5iA:
undetectable		 4a99D-1t5iA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1t5i C_TERMINAL DOMAIN OF
A PROBABLE
ATP-DEPENDENT RNA
HELICASE
(Homo
sapiens) 		4 / 6 VAL A 291
LEU A 341
LEU A 346
PHE A 381
 None
 0.97A 4o1zA-1t5iA:
undetectable		 4o1zA-1t5iA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1t5i C_TERMINAL DOMAIN OF
A PROBABLE
ATP-DEPENDENT RNA
HELICASE
(Homo
sapiens) 		3 / 4 ARG A 377
GLY A 379
GLU A 354
 None
 0.68A 4z2dB-1t5iA:
undetectable
4z2dC-1t5iA:
undetectable		 4z2dB-1t5iA:
16.39
4z2dC-1t5iA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 1t5i C_TERMINAL DOMAIN OF
A PROBABLE
ATP-DEPENDENT RNA
HELICASE
(Homo
sapiens) 		4 / 8 TYR A 371
VAL A 403
LEU A 262
ILE A 411
 None
 1.00A 5v0vA-1t5iA:
undetectable		 5v0vA-1t5iA:
15.54