SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t5j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		4 / 5 LYS A 157
ALA A 159
ASP A 224
GLY A 162
 None
 1.20A 1e7cA-1t5jA:
0.9		 1e7cA-1t5jA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		4 / 5 ASP A 253
VAL A 221
SER A 121
ASP A  97
 MG  A 500 (-3.3A)
None
None
MG  A 500 ( 4.9A)
 1.46A 1n2xB-1t5jA:
undetectable		 1n2xB-1t5jA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		4 / 6 PHE A 135
ASN A 137
ILE A 133
GLY A 132
 None
 0.99A 1oniA-1t5jA:
undetectable
1oniB-1t5jA:
undetectable		 1oniA-1t5jA:
17.20
1oniB-1t5jA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		4 / 6 PHE A 135
ASN A 137
ILE A 133
GLY A 132
 None
 1.05A 1oniD-1t5jA:
undetectable
1oniF-1t5jA:
undetectable		 1oniD-1t5jA:
17.20
1oniF-1t5jA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 139
GLY A 132
ASN A 137
ALA A 167
ALA A 163
 None
 1.08A 2bm9C-1t5jA:
undetectable		 2bm9C-1t5jA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 139
GLY A 132
SER A 150
ALA A 167
ALA A 163
 None
 1.12A 2br4C-1t5jA:
undetectable		 2br4C-1t5jA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  36
THR A  29
GLY A 251
GLY A 252
THR A 254
 None
 0.91A 2uvnA-1t5jA:
undetectable		 2uvnA-1t5jA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		3 / 3 GLY A 262
GLY A  10
GLY A  14
 None
 0.40A 3bogC-1t5jA:
undetectable		 3bogC-1t5jA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		5 / 10 ASP A  19
ILE A  17
GLY A  14
GLY A 262
ILE A 248
 None
 1.03A 3em4V-1t5jA:
undetectable		 3em4V-1t5jA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 117
GLY A 116
ARG A 127
LEU A 103
ILE A  98
 None
 1.15A 3ijdB-1t5jA:
undetectable		 3ijdB-1t5jA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		4 / 4 GLY A 218
GLU A 225
ASP A 253
ASP A 215
 None
None
MG  A 500 (-3.3A)
None
 1.43A 3mb5A-1t5jA:
undetectable		 3mb5A-1t5jA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  80
PHE A  83
ALA A  84
ILE A 106
GLY A 123
 None
 1.01A 3nxuA-1t5jA:
0.0		 3nxuA-1t5jA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		3 / 3 TYR A 189
ASP A 192
ASP A 194
 None
 0.98A 3ou7B-1t5jA:
undetectable		 3ou7B-1t5jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A  10
TYR A 296
ALA A 292
GLU A 293
 None
 0.79A 3u9hA-1t5jA:
undetectable		 3u9hA-1t5jA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A  10
TYR A 296
ALA A 292
GLU A 293
 None
 0.76A 3u9hB-1t5jA:
undetectable		 3u9hB-1t5jA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A 245
ILE A 248
GLY A  18
ILE A  17
 None
 0.86A 3wxoA-1t5jA:
undetectable		 3wxoA-1t5jA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A  10
TYR A 296
ALA A 292
GLU A 293
 None
 0.75A 4bjcA-1t5jA:
undetectable		 4bjcA-1t5jA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		5 / 12 PRO A  96
LEU A  54
GLY A 220
ASP A 253
THR A  60
 None
None
None
MG  A 500 (-3.3A)
MG  A 500 (-3.9A)
 1.29A 4mubA-1t5jA:
undetectable		 4mubA-1t5jA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  73
ALA A 299
ILE A 128
ALA A 267
ILE A   8
 None
 0.93A 4nkxB-1t5jA:
undetectable		 4nkxB-1t5jA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 149
GLY A  77
ILE A   8
GLY A 132
TYR A 129
 None
 1.12A 4r29D-1t5jA:
undetectable		 4r29D-1t5jA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  80
PHE A  83
ALA A  84
ALA A 105
GLY A 123
 None
 0.94A 5veuA-1t5jA:
0.0		 5veuA-1t5jA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  80
PHE A  83
ALA A  84
ALA A 105
GLY A 123
 None
 0.98A 5veuB-1t5jA:
undetectable		 5veuB-1t5jA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		5 / 11 GLY A 162
ALA A 161
ALA A 165
ILE A 231
VAL A 227
 None
 1.02A 5yk2A-1t5jA:
1.5		 5yk2A-1t5jA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 1t5j HYPOTHETICAL PROTEIN
MJ1187
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A 257
ALA A 258
LEU A 210
THR A 237
 None
 0.89A 6f88B-1t5jA:
0.0		 6f88B-1t5jA:
16.67