SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t5o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		4 / 4 ARG A 100
ALA A  55
ALA A 126
GLU A 128
 None
 1.07A 1e7bB-1t5oA:
undetectable		 1e7bB-1t5oA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		4 / 8 THR A  87
GLY A  54
ALA A  80
ILE A  58
 None
 0.81A 1gtnA-1t5oA:
undetectable
1gtnB-1t5oA:
undetectable		 1gtnA-1t5oA:
13.33
1gtnB-1t5oA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		5 / 10 ARG A 132
THR A 269
ALA A  47
GLY A 232
THR A 166
 None
 1.07A 1gtnB-1t5oA:
undetectable
1gtnC-1t5oA:
undetectable		 1gtnB-1t5oA:
13.33
1gtnC-1t5oA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		4 / 8 THR A  87
GLY A  54
ALA A  80
ILE A  58
 None
 0.80A 1gtnE-1t5oA:
undetectable
1gtnF-1t5oA:
undetectable		 1gtnE-1t5oA:
13.33
1gtnF-1t5oA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		4 / 8 THR A 269
ALA A  47
GLY A 232
THR A 166
 None
 0.59A 1gtnI-1t5oA:
undetectable
1gtnJ-1t5oA:
undetectable		 1gtnI-1t5oA:
13.33
1gtnJ-1t5oA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 156
ASN A 243
THR A 269
ILE A 236
LEU A 320
 None
 1.13A 1rg7A-1t5oA:
2.1		 1rg7A-1t5oA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		4 / 8 GLY A  54
ALA A  80
ILE A  58
THR A  87
 None
 0.80A 1utdB-1t5oA:
undetectable
1utdC-1t5oA:
undetectable		 1utdB-1t5oA:
13.33
1utdC-1t5oA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		4 / 8 GLY A  54
ALA A  80
ILE A  58
THR A  87
 None
 0.81A 1utdF-1t5oA:
undetectable
1utdG-1t5oA:
undetectable		 1utdF-1t5oA:
13.33
1utdG-1t5oA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		4 / 4 ILE A  15
ASP A   9
LEU A  12
ARG A 158
 None
 1.24A 2a7qA-1t5oA:
undetectable		 2a7qA-1t5oA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		3 / 3 GLY A 157
GLY A 169
GLY A 165
 None
 0.40A 3bogC-1t5oA:
undetectable		 3bogC-1t5oA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		4 / 5 ASN A  93
ARG A 132
ASN A 133
ALA A 160
 None
 1.16A 3frqA-1t5oA:
1.7		 3frqA-1t5oA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		4 / 7 ASN A  93
ARG A 132
ASN A 133
ALA A 160
 None
 1.18A 3frqB-1t5oA:
1.7		 3frqB-1t5oA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		3 / 3 PRO A 299
LEU A 300
GLN A 296
 None
 0.43A 3hznG-1t5oA:
undetectable
3hznH-1t5oA:
undetectable		 3hznG-1t5oA:
23.35
3hznH-1t5oA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 151
VAL A 229
GLY A 218
VAL A 253
THR A 312
 None
 0.97A 4m2vA-1t5oA:
undetectable		 4m2vA-1t5oA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		4 / 5 ILE A 212
ARG A 182
ASP A 227
VAL A 250
 None
 1.08A 4nkxC-1t5oA:
undetectable		 4nkxC-1t5oA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		4 / 5 ILE A 212
ARG A 182
ASP A 227
VAL A 250
 None
 1.09A 4nkxD-1t5oA:
undetectable		 4nkxD-1t5oA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 168
GLY A 165
ARG A  45
MET A 136
ILE A 321
 None
 1.33A 4oktA-1t5oA:
undetectable		 4oktA-1t5oA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		5 / 12 ARG A 132
THR A 269
ALA A  47
GLY A 232
THR A 166
 None
 1.03A 5eeuI-1t5oA:
undetectable
5eeuJ-1t5oA:
undetectable		 5eeuI-1t5oA:
13.33
5eeuJ-1t5oA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		5 / 12 ARG A 132
THR A 269
ALA A  47
GLY A 232
THR A 166
 None
 1.03A 5eevI-1t5oA:
undetectable
5eevJ-1t5oA:
undetectable		 5eevI-1t5oA:
13.33
5eevJ-1t5oA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		5 / 12 ARG A 132
THR A 269
ALA A  47
GLY A 232
THR A 166
 None
 1.03A 5eewI-1t5oA:
undetectable
5eewJ-1t5oA:
undetectable		 5eewI-1t5oA:
13.33
5eewJ-1t5oA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		3 / 3 TRP A 272
GLU A 332
ASP A 239
 None
 0.73A 5gqbA-1t5oA:
2.1		 5gqbA-1t5oA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  46
GLN A  17
ALA A  52
ALA A  53
ILE A   6
 None
 0.80A 5kb6A-1t5oA:
2.1		 5kb6A-1t5oA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  46
GLN A  17
ALA A  52
ALA A  53
ILE A   6
 None
 0.82A 5kb6B-1t5oA:
3.3		 5kb6B-1t5oA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  54
GLY A  97
ALA A  85
LEU A  84
ALA A  80
 None
 0.77A 5kpcA-1t5oA:
4.1		 5kpcA-1t5oA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		5 / 8 VAL A 217
ILE A 212
ALA A 185
THR A 152
VAL A 229
 None
 1.47A 5l94A-1t5oA:
undetectable		 5l94A-1t5oA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		5 / 8 VAL A 220
ILE A 212
ALA A 185
VAL A 149
VAL A 226
 None
 0.97A 5l94A-1t5oA:
undetectable		 5l94A-1t5oA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		4 / 5 LEU A  77
LYS A  78
ALA A  81
LEU A  84
 None
 0.70A 5vkqA-1t5oA:
2.3
5vkqD-1t5oA:
2.3		 5vkqA-1t5oA:
12.03
5vkqD-1t5oA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		4 / 5 LEU A  77
LYS A  78
ALA A  81
LEU A  84
 None
 0.70A 5vkqA-1t5oA:
2.3
5vkqB-1t5oA:
2.3		 5vkqA-1t5oA:
12.03
5vkqB-1t5oA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		4 / 5 LEU A  77
LYS A  78
ALA A  81
LEU A  84
 None
 0.69A 5vkqB-1t5oA:
1.2
5vkqC-1t5oA:
1.2		 5vkqB-1t5oA:
12.03
5vkqC-1t5oA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		4 / 5 LEU A  77
LYS A  78
ALA A  81
LEU A  84
 None
 0.70A 5vkqC-1t5oA:
2.3
5vkqD-1t5oA:
2.3		 5vkqC-1t5oA:
12.03
5vkqD-1t5oA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA
(Archaeoglobus
fulgidus) 		3 / 3 GLY A 206
ASP A 208
ILE A 181
 None
 0.62A 6dgxB-1t5oA:
undetectable		 6dgxB-1t5oA:
15.02