SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t5r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_C_RBTC8001_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN
RNA POLYMERASE SIGMA
FACTOR RPOD)		 1t5r LUKS-PV
(Staphylococcus
phage
PVL) 		5 / 11 GLN A  32
PHE A 226
SER A 209
ILE A 135
ASP A  34
 None
 1.38A 2a68C-1t5rA:
0.0
2a68F-1t5rA:
undetectable		 2a68C-1t5rA:
12.62
2a68F-1t5rA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 1t5r LUKS-PV
(Staphylococcus
phage
PVL) 		4 / 6 ASN A 262
ASN A 233
ILE A 158
GLN A  77
 None
 0.71A 2hkkA-1t5rA:
undetectable		 2hkkA-1t5rA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1t5r LUKS-PV
(Staphylococcus
phage
PVL) 		4 / 8 TRP A 273
PHE A  35
GLU A 270
SER A 224
 None
 1.37A 3jx1A-1t5rA:
undetectable
3jx1B-1t5rA:
undetectable		 3jx1A-1t5rA:
20.66
3jx1B-1t5rA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1t5r LUKS-PV
(Staphylococcus
phage
PVL) 		4 / 7 VAL A 193
VAL A 202
PHE A 163
GLU A 197
 None
 1.22A 3jx6A-1t5rA:
undetectable
3jx6B-1t5rA:
undetectable		 3jx6A-1t5rA:
20.66
3jx6B-1t5rA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1t5r LUKS-PV
(Staphylococcus
phage
PVL) 		4 / 7 VAL A 193
VAL A 202
PHE A 163
GLU A 197
 None
 1.23A 3nljA-1t5rA:
undetectable
3nljB-1t5rA:
undetectable		 3nljA-1t5rA:
20.66
3nljB-1t5rA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1t5r LUKS-PV
(Staphylococcus
phage
PVL) 		4 / 7 PHE A 163
GLU A 197
VAL A 193
VAL A 202
 None
 1.24A 3nljA-1t5rA:
undetectable
3nljB-1t5rA:
undetectable		 3nljA-1t5rA:
20.66
3nljB-1t5rA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1t5r LUKS-PV
(Staphylococcus
phage
PVL) 		4 / 7 PHE A 163
GLU A 197
VAL A 193
VAL A 202
 None
 1.23A 3nlqA-1t5rA:
undetectable
3nlqB-1t5rA:
undetectable		 3nlqA-1t5rA:
20.66
3nlqB-1t5rA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1t5r LUKS-PV
(Staphylococcus
phage
PVL) 		5 / 12 VAL A 280
PHE A  33
ILE A 228
LEU A  82
VAL A 214
 None
 1.11A 3w68B-1t5rA:
undetectable		 3w68B-1t5rA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUF_A_ACTA605_0
(SERUM ALBUMIN)		 1t5r LUKS-PV
(Staphylococcus
phage
PVL) 		4 / 4 ALA A 160
HIS A 173
PHE A  76
LEU A 177
 None
 1.27A 4lufA-1t5rA:
undetectable		 4lufA-1t5rA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA609_0
(SERUM ALBUMIN)		 1t5r LUKS-PV
(Staphylococcus
phage
PVL) 		4 / 4 ALA A 160
HIS A 173
PHE A  76
LEU A 177
 None
 1.29A 4luhA-1t5rA:
undetectable		 4luhA-1t5rA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1t5r LUKS-PV
(Staphylococcus
phage
PVL) 		4 / 7 PHE A 163
GLU A 197
VAL A 193
VAL A 202
 None
 1.19A 5adeA-1t5rA:
undetectable
5adeB-1t5rA:
undetectable		 5adeA-1t5rA:
20.66
5adeB-1t5rA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1t5r LUKS-PV
(Staphylococcus
phage
PVL) 		4 / 7 VAL A 193
VAL A 202
PHE A 163
GLU A 197
 None
 1.27A 5g0pA-1t5rA:
undetectable
5g0pB-1t5rA:
undetectable		 5g0pA-1t5rA:
20.66
5g0pB-1t5rA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1t5r LUKS-PV
(Staphylococcus
phage
PVL) 		3 / 3 VAL A 103
LEU A 177
MET A 170
 None
 0.79A 5ikrA-1t5rA:
undetectable		 5ikrA-1t5rA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 1t5r LUKS-PV
(Staphylococcus
phage
PVL) 		4 / 8 GLY A 157
SER A 144
PHE A 206
TYR A 230
 None
 1.15A 6eqpA-1t5rA:
undetectable		 6eqpA-1t5rA:
15.36