SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t66'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 1t66 IMMUNOGLOBULIN HEAVY
CHAIN
(Mus
musculus) 		4 / 8 GLY H  94
TYR H  96
GLU H  42
SER H  40
 None
 1.09A 1maaD-1t66H:
undetectable		 1maaD-1t66H:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 1t66 IMMUNOGLOBULIN HEAVY
CHAIN
(Mus
musculus) 		5 / 12 LYS H  19
LEU H   4
ASP H   5
SER H  80
PHE H  29
 None
 1.38A 2b9eA-1t66H:
undetectable		 2b9eA-1t66H:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 1t66 IMMUNOGLOBULIN HEAVY
CHAIN
(Mus
musculus) 		5 / 12 LEU H 143
VAL H 168
GLY H 162
VAL H 188
VAL H 186
 None
 0.88A 2ieoB-1t66H:
undetectable		 2ieoB-1t66H:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 1t66 IMMUNOGLOBULIN HEAVY
CHAIN
(Mus
musculus) 		3 / 3 VAL H  81
ASN H  35
TRP H  47
 None
 1.12A 2y00B-1t66H:
undetectable		 2y00B-1t66H:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 1t66 IMMUNOGLOBULIN HEAVY
CHAIN
(Mus
musculus) 		5 / 12 VAL H 168
VAL H 186
SER H 184
ASN H 201
ASN H 160
 None
 1.43A 3nyaA-1t66H:
undetectable		 3nyaA-1t66H:
17.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 1t66 IMMUNOGLOBULIN HEAVY
CHAIN
(Mus
musculus) 		6 / 12 LEU H   4
ALA H  24
MET H  34
ARG H  74
VAL H  81
TYR H 107
 None
 0.68A 3qxtB-1t66H:
19.7		 3qxtB-1t66H:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 1t66 IMMUNOGLOBULIN HEAVY
CHAIN
(Mus
musculus) 		6 / 12 VAL H   2
LEU H   4
MET H  34
ARG H  74
VAL H  81
TYR H 107
 None
 0.69A 3qxtB-1t66H:
19.7		 3qxtB-1t66H:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1t66 IMMUNOGLOBULIN HEAVY
CHAIN
(Mus
musculus) 		6 / 12 VAL H   2
ALA H  24
MET H  34
ARG H  74
VAL H  81
TYR H 107
 None
 0.86A 3qxvA-1t66H:
19.3		 3qxvA-1t66H:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1t66 IMMUNOGLOBULIN HEAVY
CHAIN
(Mus
musculus) 		6 / 12 VAL H   2
ALA H  24
MET H  34
ARG H  74
VAL H  81
TYR H 107
 None
 0.91A 3qxvB-1t66H:
19.2		 3qxvB-1t66H:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1t66 IMMUNOGLOBULIN HEAVY
CHAIN
(Mus
musculus) 		5 / 12 ALA H  24
MET H  34
ARG H  74
VAL H  81
TYR H 107
 None
 0.79A 3qxvD-1t66H:
19.3		 3qxvD-1t66H:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1t66 IMMUNOGLOBULIN HEAVY
CHAIN
(Mus
musculus) 		5 / 12 VAL H   2
MET H  34
ARG H  74
VAL H  81
TYR H 107
 None
 0.76A 3qxvD-1t66H:
19.3		 3qxvD-1t66H:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 1t66 IMMUNOGLOBULIN HEAVY
CHAIN
(Mus
musculus) 		4 / 5 SER H 117
ALA H 119
PHE H 151
LEU H 175
 None
 0.30A 5mthA-1t66H:
26.2		 5mthA-1t66H:
64.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 1t66 IMMUNOGLOBULIN HEAVY
CHAIN
(Mus
musculus) 		3 / 3 SER H 208
ALA H 203
VAL H 202
 None
 0.52A 5xiwC-1t66H:
undetectable		 5xiwC-1t66H:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 1t66 IMMUNOGLOBULIN HEAVY
CHAIN
(Mus
musculus) 		3 / 3 TYR H  62
GLY H  68
THR H  71
 None
 0.19A 6cjkB-1t66H:
24.7		 6cjkB-1t66H:
58.48