SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t6k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		6 / 11 ALA A  58
LEU A  94
LEU A  92
LEU A 105
ILE A  81
ALA A  82
 None
 1.41A 1ha2A-1t6kA:
undetectable		 1ha2A-1t6kA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		4 / 8 THR A 211
GLY A  73
GLN A 119
PRO A 153
 SO4  A 301 (-3.9A)
SO4  A 301 (-3.6A)
None
None
 0.81A 1rxcB-1t6kA:
undetectable		 1rxcB-1t6kA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		4 / 8 THR A 211
GLY A  73
GLN A 119
PRO A 153
 SO4  A 301 (-3.9A)
SO4  A 301 (-3.6A)
None
None
 0.81A 1rxcE-1t6kA:
undetectable		 1rxcE-1t6kA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		4 / 8 THR A 211
GLY A  73
GLN A 119
PRO A 153
 SO4  A 301 (-3.9A)
SO4  A 301 (-3.6A)
None
None
 0.86A 1rxcI-1t6kA:
undetectable		 1rxcI-1t6kA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		4 / 8 THR A 211
GLY A  73
GLN A 119
PRO A 153
 SO4  A 301 (-3.9A)
SO4  A 301 (-3.6A)
None
None
 0.81A 1rxcK-1t6kA:
undetectable		 1rxcK-1t6kA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_A_T98A201_1
(PROGESTERONE
RECEPTOR)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		5 / 10 LEU A 160
LEU A 176
LEU A 134
THR A 143
PHE A 187
 None
 1.35A 1zucA-1t6kA:
undetectable		 1zucA-1t6kA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		5 / 11 PHE A  71
GLY A  78
THR A  79
ALA A  80
VAL A 264
 None
 1.19A 2cojA-1t6kA:
undetectable
2cojB-1t6kA:
undetectable		 2cojA-1t6kA:
21.72
2cojB-1t6kA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		5 / 12 PRO A  31
ALA A  82
LEU A  83
ALA A  80
GLN A  97
 None
 1.21A 2jjpA-1t6kA:
undetectable		 2jjpA-1t6kA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		4 / 4 ARG A 197
GLY A 239
GLU A 241
SER A 213
 None
None
None
SO4  A 301 (-2.7A)
 1.18A 2xctS-1t6kA:
undetectable
2xctU-1t6kA:
undetectable		 2xctS-1t6kA:
18.04
2xctU-1t6kA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B600_1
(ORF12)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		5 / 11 ALA A  82
THR A  47
ALA A  80
GLY A  78
PHE A 103
 None
 1.39A 2xfsB-1t6kA:
1.1		 2xfsB-1t6kA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		5 / 12 ASP A 130
ILE A 146
PHE A 187
TYR A 149
LEU A 218
 None
 1.48A 2ya7C-1t6kA:
undetectable		 2ya7C-1t6kA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		4 / 4 GLN A 232
PRO A 233
VAL A 234
GLU A 235
 None
 0.84A 3huoA-1t6kA:
0.0		 3huoA-1t6kA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		4 / 8 THR A 211
GLY A  73
GLN A 119
PRO A 153
 SO4  A 301 (-3.9A)
SO4  A 301 (-3.6A)
None
None
 0.82A 4e1vA-1t6kA:
undetectable		 4e1vA-1t6kA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		4 / 8 THR A 211
GLY A  73
GLN A 119
PRO A 153
 SO4  A 301 (-3.9A)
SO4  A 301 (-3.6A)
None
None
 0.80A 4e1vC-1t6kA:
undetectable		 4e1vC-1t6kA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		4 / 8 THR A 211
GLY A  73
GLN A 119
PRO A 153
 SO4  A 301 (-3.9A)
SO4  A 301 (-3.6A)
None
None
 0.80A 4e1vD-1t6kA:
undetectable		 4e1vD-1t6kA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		4 / 8 THR A 211
GLY A  73
GLN A 119
PRO A 153
 SO4  A 301 (-3.9A)
SO4  A 301 (-3.6A)
None
None
 0.82A 4e1vE-1t6kA:
undetectable		 4e1vE-1t6kA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		4 / 8 THR A 211
GLY A  73
GLN A 119
PRO A 153
 SO4  A 301 (-3.9A)
SO4  A 301 (-3.6A)
None
None
 0.68A 4e1vG-1t6kA:
undetectable		 4e1vG-1t6kA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		4 / 8 THR A 211
GLY A  73
GLN A 119
PRO A 153
 SO4  A 301 (-3.9A)
SO4  A 301 (-3.6A)
None
None
 0.81A 4e1vH-1t6kA:
undetectable		 4e1vH-1t6kA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		4 / 7 LEU A 176
ALA A 183
VAL A 205
ILE A 236
 None
 0.91A 4eyrA-1t6kA:
undetectable		 4eyrA-1t6kA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		3 / 3 TYR A 149
HIS A 225
ARG A 224
 None
 1.15A 4htfA-1t6kA:
undetectable		 4htfA-1t6kA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		5 / 12 LEU A  83
LEU A  94
GLY A  73
HIS A  74
LEU A  77
 None
None
SO4  A 301 (-3.6A)
SO4  A 301 (-4.2A)
None
 1.26A 4j26A-1t6kA:
undetectable		 4j26A-1t6kA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		6 / 11 ASP A  57
VAL A  49
GLY A  84
ILE A  81
THR A  47
ILE A  60
 None
 1.17A 4njvB-1t6kA:
undetectable		 4njvB-1t6kA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		5 / 12 ILE A  60
THR A  47
ALA A  82
LEU A  94
LEU A  92
 None
 1.47A 4pbhA-1t6kA:
undetectable		 4pbhA-1t6kA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		5 / 12 GLN A  35
LEU A  69
ALA A  38
ASN A  42
GLY A 204
 None
 1.15A 4qckA-1t6kA:
undetectable		 4qckA-1t6kA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		5 / 12 HIS A 155
ALA A 183
SER A 200
GLY A 152
GLY A  73
 None
None
None
None
SO4  A 301 (-3.6A)
 1.19A 4uilH-1t6kA:
undetectable
4uilL-1t6kA:
undetectable		 4uilH-1t6kA:
20.42
4uilL-1t6kA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		4 / 5 HIS A 221
VAL A 234
GLY A 216
ALA A 215
 None
 1.02A 5hwaA-1t6kA:
0.0		 5hwaA-1t6kA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		5 / 12 LEU A  94
LEU A  92
LEU A 105
ILE A  81
ALA A  82
 None
 1.15A 5v0vA-1t6kA:
0.0		 5v0vA-1t6kA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		5 / 11 GLU A 235
GLY A 216
ALA A 215
ALA A 219
VAL A 262
 None
 1.16A 5yk2A-1t6kA:
undetectable		 5yk2A-1t6kA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		5 / 12 LEU A 134
ILE A 139
GLY A 138
ILE A 146
VAL A 156
 None
 0.88A 6emuA-1t6kA:
undetectable		 6emuA-1t6kA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		5 / 12 LEU A 134
ILE A 139
GLY A 138
ILE A 146
VAL A 156
 None
 0.91A 6emuB-1t6kA:
undetectable		 6emuB-1t6kA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF
(Pseudomonas
fluorescens) 		5 / 12 LEU A 134
ILE A 139
GLY A 138
ILE A 146
VAL A 156
 None
 0.91A 6emuC-1t6kA:
undetectable		 6emuC-1t6kA:
21.95