SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t6p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		3 / 3 GLU A 248
ALA A 246
SER A 231
 None
 0.67A 1errB-1t6pA:
1.7		 1errB-1t6pA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 12 LEU A 665
LEU A 532
ILE A 691
LEU A 292
LEU A 711
 None
 1.14A 1errB-1t6pA:
undetectable		 1errB-1t6pA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		4 / 8 LEU A 481
LEU A 522
TYR A 699
LYS A 703
 None
 1.25A 1hk2A-1t6pA:
0.9		 1hk2A-1t6pA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		4 / 8 ARG A  80
SER A  58
SER A  74
ASP A  71
 None
 1.20A 1hwkA-1t6pA:
undetectable		 1hwkA-1t6pA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		4 / 8 ARG A  80
SER A  58
SER A  74
ASP A  71
 None
 1.17A 1hwkC-1t6pA:
undetectable		 1hwkC-1t6pA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		4 / 8 ARG A  80
SER A  58
SER A  74
ASP A  71
 None
 1.17A 1hwkD-1t6pA:
undetectable		 1hwkD-1t6pA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		4 / 5 LEU A 379
LEU A 375
LEU A 427
LEU A 429
 None
 0.99A 2ab2B-1t6pA:
0.0		 2ab2B-1t6pA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 7 LEU A 528
GLY A 692
ILE A 691
VAL A 669
ILE A 698
 None
 1.33A 2aojB-1t6pA:
undetectable		 2aojB-1t6pA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 12 HIS A 344
SER A 339
ARG A 366
VAL A 301
ILE A 332
 None
 1.25A 2fj1A-1t6pA:
1.5		 2fj1A-1t6pA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		3 / 3 LEU A 581
LEU A 573
PHE A 601
 None
 0.74A 2pgrA-1t6pA:
undetectable		 2pgrA-1t6pA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 11 LEU A 386
ALA A 510
THR A 514
ARG A 166
LEU A 281
 None
 1.36A 2v0mD-1t6pA:
0.0		 2v0mD-1t6pA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		3 / 3 HIS A 284
MET A 288
MET A  51
 None
 1.36A 2vj1A-1t6pA:
undetectable		 2vj1A-1t6pA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VKE_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 11 HIS A 344
SER A 339
ARG A 366
VAL A 301
ILE A 332
 None
 1.42A 2vkeA-1t6pA:
0.0		 2vkeA-1t6pA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 12 LEU A  62
GLY A  64
LEU A  60
SER A  66
GLY A 167
 None
 1.06A 2vmyA-1t6pA:
undetectable		 2vmyA-1t6pA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 12 GLY A 271
ASN A 270
ILE A 171
GLY A 167
THR A 280
 175  A 211 ( 4.6A)
175  A 211 ( 4.0A)
None
None
None
 1.15A 3eeyC-1t6pA:
undetectable		 3eeyC-1t6pA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 12 GLY A 271
ASN A 270
ILE A 171
GLY A 167
THR A 280
 175  A 211 ( 4.6A)
175  A 211 ( 4.0A)
None
None
None
 1.15A 3eeyE-1t6pA:
undetectable		 3eeyE-1t6pA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 8 LEU A 636
SER A 635
LEU A 585
ARG A 641
PHE A 544
 None
 1.44A 3ln1A-1t6pA:
0.0		 3ln1A-1t6pA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 7 LEU A 636
SER A 635
LEU A 585
ARG A 641
PHE A 544
 None
 1.44A 3ln1B-1t6pA:
0.0		 3ln1B-1t6pA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		4 / 7 SER A 635
LEU A 585
ARG A 641
PHE A 544
 None
 1.07A 3ln1C-1t6pA:
0.0		 3ln1C-1t6pA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		4 / 7 PRO A 201
LEU A 139
ILE A 221
MET A 169
 None
 1.03A 3u5jA-1t6pA:
undetectable		 3u5jA-1t6pA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		4 / 5 LEU A 283
HIS A 383
HIS A 381
HIS A  36
 None
 1.27A 4a7bB-1t6pA:
undetectable		 4a7bB-1t6pA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 12 PHE A 311
ARG A 362
PRO A 364
GLN A 370
SER A 310
 None
 1.40A 4abzA-1t6pA:
1.3		 4abzA-1t6pA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		4 / 7 HIS A 527
ASN A 436
LEU A 435
PHE A 311
 None
 1.18A 4awuA-1t6pA:
undetectable		 4awuA-1t6pA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		4 / 7 ALA A 506
ALA A 276
ALA A 417
THR A 421
 None
 0.82A 4du2A-1t6pA:
0.0		 4du2A-1t6pA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		4 / 7 ALA A 506
ALA A 276
ALA A 417
THR A 421
 None
 0.88A 4du2B-1t6pA:
undetectable		 4du2B-1t6pA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		3 / 3 ARG A 178
HIS A 180
TYR A  65
 None
 1.33A 4fu8A-1t6pA:
undetectable		 4fu8A-1t6pA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		3 / 3 LEU A 507
ILE A 508
ARG A 512
 None
 0.64A 4mk4B-1t6pA:
undetectable		 4mk4B-1t6pA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		4 / 4 ASN A 174
GLY A 391
ASP A 285
ASP A  71
 None
 1.25A 4n49A-1t6pA:
undetectable		 4n49A-1t6pA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		3 / 3 SER A  35
ALA A  33
VAL A  32
 None
 0.66A 4o2bC-1t6pA:
undetectable		 4o2bC-1t6pA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 10 CYH A 530
LEU A 440
LEU A 470
ALA A 474
LEU A 523
 None
 1.28A 4p65A-1t6pA:
undetectable
4p65B-1t6pA:
undetectable
4p65F-1t6pA:
undetectable
4p65H-1t6pA:
undetectable		 4p65A-1t6pA:
2.79
4p65B-1t6pA:
4.70
4p65F-1t6pA:
4.70
4p65H-1t6pA:
4.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2G_B_CTCB222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 12 HIS A 344
SER A 339
ARG A 366
VAL A 301
ILE A 332
 None
 1.31A 4v2gB-1t6pA:
1.1		 4v2gB-1t6pA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 10 GLU A 671
LEU A 658
ALA A 654
ASP A 536
SER A 652
 None
 1.22A 4wnuD-1t6pA:
3.1		 4wnuD-1t6pA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 12 LEU A 386
ASN A 420
THR A 489
ALA A 506
ALA A 279
 None
 0.99A 4x1iB-1t6pA:
undetectable		 4x1iB-1t6pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 12 LEU A 386
ASN A 420
THR A 489
ALA A 506
ALA A 279
 None
 1.12A 4x1iD-1t6pA:
undetectable		 4x1iD-1t6pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 12 LEU A 386
ASN A 420
THR A 489
ALA A 506
ALA A 279
 None
 1.04A 4x1kD-1t6pA:
undetectable		 4x1kD-1t6pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 12 LEU A 386
ASN A 420
THR A 489
ALA A 506
ALA A 279
 None
 0.89A 4x20B-1t6pA:
undetectable		 4x20B-1t6pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		3 / 3 THR A 513
ALA A 282
ASN A 517
 None
 0.53A 5ersA-1t6pA:
undetectable		 5ersA-1t6pA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		3 / 3 PRO A 369
LEU A 335
SER A 310
 None
 0.82A 5fsaB-1t6pA:
1.5		 5fsaB-1t6pA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 12 ALA A 506
VAL A 418
SER A 175
LEU A 160
ILE A 221
 None
 0.94A 5hv1A-1t6pA:
0.0		 5hv1A-1t6pA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		4 / 8 THR A 513
ALA A 506
ASP A 214
SER A 210
 None
None
175  A 211 ( 4.2A)
175  A 211 ( 4.7A)
 1.10A 5l5fY-1t6pA:
undetectable
5l5fZ-1t6pA:
undetectable		 5l5fY-1t6pA:
14.89
5l5fZ-1t6pA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		4 / 6 ASP A  95
ASP A  63
ARG A 178
ASN A 174
 None
 1.14A 5l6eA-1t6pA:
undetectable		 5l6eA-1t6pA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 12 LEU A 386
ASN A 420
THR A 489
ALA A 506
ALA A 279
 None
 1.09A 5nm5B-1t6pA:
undetectable		 5nm5B-1t6pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		3 / 3 LEU A 379
LEU A 375
TRP A 371
 None
 0.85A 5nwuA-1t6pA:
0.0		 5nwuA-1t6pA:
6.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 12 LEU A 372
GLN A  44
VAL A  45
GLN A 439
LEU A 296
 None
 1.19A 5uc3B-1t6pA:
undetectable		 5uc3B-1t6pA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		3 / 3 LEU A 712
VAL A  45
ASP A  46
 None
 0.66A 5x23A-1t6pA:
undetectable		 5x23A-1t6pA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		4 / 6 ARG A 172
VAL A 187
LEU A 191
VAL A 258
 None
 0.88A 5x7zA-1t6pA:
0.4		 5x7zA-1t6pA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 12 LEU A 386
ASN A 420
THR A 489
ALA A 506
ALA A 279
 None
 1.01A 5xiwB-1t6pA:
undetectable		 5xiwB-1t6pA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 12 LEU A 532
ALA A 701
SER A 704
LEU A 528
LEU A 711
 None
 1.13A 6ew0B-1t6pA:
undetectable		 6ew0B-1t6pA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 12 LEU A 532
ALA A 701
SER A 704
LEU A 528
LEU A 711
 None
 1.13A 6ew0D-1t6pA:
undetectable		 6ew0D-1t6pA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 12 LEU A 532
ALA A 701
SER A 704
LEU A 528
LEU A 711
 None
 1.13A 6ew0F-1t6pA:
undetectable		 6ew0F-1t6pA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 12 LEU A 532
ALA A 701
SER A 704
LEU A 528
LEU A 711
 None
 1.13A 6ew0G-1t6pA:
undetectable		 6ew0G-1t6pA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 12 LEU A 532
ALA A 701
SER A 704
LEU A 528
LEU A 711
 None
 1.13A 6ew0H-1t6pA:
undetectable		 6ew0H-1t6pA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 12 LEU A 532
ALA A 701
SER A 704
LEU A 528
LEU A 711
 None
 1.13A 6ew0I-1t6pA:
undetectable		 6ew0I-1t6pA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1t6p PHENYLALANINE
AMMONIA-LYASE
(Rhodotorula
toruloides) 		5 / 12 ASP A 396
ILE A 171
PRO A 217
SER A 175
ASP A 214
 None
None
None
None
175  A 211 ( 4.2A)
 1.45A 6fbpA-1t6pA:
undetectable
6fbpB-1t6pA:
undetectable		 6fbpA-1t6pA:
8.45
6fbpB-1t6pA:
8.45