SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t6r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_C_RABC647_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1t6r PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1442
(Thermotoga
maritima) 		5 / 9 VAL A 107
GLU A 108
SER A  83
ASP A  50
ILE A  16
 None
 1.15A 1pw7C-1t6rA:
undetectable		 1pw7C-1t6rA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 1t6r PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1442
(Thermotoga
maritima) 		5 / 11 ILE A   8
LEU A   6
ASP A  22
GLY A  61
VAL A  19
 None
None
None
SEP  A  59 ( 4.1A)
None
 0.92A 2fxdA-1t6rA:
undetectable		 2fxdA-1t6rA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1t6r PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1442
(Thermotoga
maritima) 		3 / 3 ILE A  47
ILE A   8
LEU A  92
 None
 0.47A 2prgA-1t6rA:
undetectable		 2prgA-1t6rA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1t6r PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1442
(Thermotoga
maritima) 		5 / 12 LEU A  81
LEU A  62
LEU A  65
VAL A  66
ILE A 100
 None
SEP  A  59 ( 3.9A)
None
None
None
 0.94A 3adxB-1t6rA:
undetectable		 3adxB-1t6rA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 1t6r PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1442
(Thermotoga
maritima) 		5 / 10 LEU A  65
ARG A  36
PHE A  38
ASP A  50
PHE A 101
 None
 1.47A 4driB-1t6rA:
undetectable		 4driB-1t6rA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 1t6r PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1442
(Thermotoga
maritima) 		3 / 3 LYS A  73
LEU A  69
ALA A  72
 None
 0.85A 4iizA-1t6rA:
undetectable		 4iizA-1t6rA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1t6r PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1442
(Thermotoga
maritima) 		4 / 8 LEU A  62
LEU A  65
VAL A  66
ILE A 100
 SEP  A  59 ( 3.9A)
None
None
None
 0.86A 4oj4A-1t6rA:
undetectable		 4oj4A-1t6rA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 1t6r PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1442
(Thermotoga
maritima) 		5 / 11 LEU A   6
LEU A   4
LEU A  81
LEU A  49
LEU A  92
 None
 1.04A 4zowA-1t6rA:
undetectable		 4zowA-1t6rA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 1t6r PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1442
(Thermotoga
maritima) 		5 / 9 VAL A  19
VAL A  17
PHE A  38
ILE A  47
PHE A  79
 None
 1.20A 5e4dA-1t6rA:
0.0		 5e4dA-1t6rA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 1t6r PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1442
(Thermotoga
maritima) 		4 / 8 SER A  82
THR A 104
ARG A  18
ILE A  16
 None
 1.03A 5jhdE-1t6rA:
undetectable
5jhdG-1t6rA:
undetectable		 5jhdE-1t6rA:
21.01
5jhdG-1t6rA:
23.33