SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t6s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 1t6s CONSERVED
HYPOTHETICAL PROTEIN
(Chlorobaculum
tepidum) 		5 / 12 ASN A  49
ASP A  46
GLU A  47
ASP A  51
ARG A   5
 None
NO3  A 407 ( 4.9A)
None
None
None
 1.27A 1s14A-1t6sA:
undetectable		 1s14A-1t6sA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 1t6s CONSERVED
HYPOTHETICAL PROTEIN
(Chlorobaculum
tepidum) 		5 / 12 ASN A  49
ASP A  46
GLU A  47
ASP A  51
ARG A   5
 None
NO3  A 407 ( 4.9A)
None
None
None
 1.26A 1s14B-1t6sA:
undetectable		 1s14B-1t6sA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 1t6s CONSERVED
HYPOTHETICAL PROTEIN
(Chlorobaculum
tepidum) 		5 / 12 ASN A  49
ASP A  46
ASP A  51
ARG A   5
ILE A  16
 None
NO3  A 407 ( 4.9A)
None
None
None
 1.15A 3lpsA-1t6sA:
undetectable		 3lpsA-1t6sA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 1t6s CONSERVED
HYPOTHETICAL PROTEIN
(Chlorobaculum
tepidum) 		5 / 12 ASN A  49
ASP A  46
GLU A  47
ASP A  51
ARG A   5
 None
NO3  A 407 ( 4.9A)
None
None
None
 1.29A 3lpsA-1t6sA:
undetectable		 3lpsA-1t6sA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 1t6s CONSERVED
HYPOTHETICAL PROTEIN
(Chlorobaculum
tepidum) 		5 / 11 ASP A  46
LEU A  41
LEU A  12
LEU A   9
TYR A  52
 NO3  A 407 ( 4.9A)
None
None
None
None
 1.09A 4odrA-1t6sA:
undetectable
4odrB-1t6sA:
undetectable		 4odrA-1t6sA:
20.83
4odrB-1t6sA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 1t6s CONSERVED
HYPOTHETICAL PROTEIN
(Chlorobaculum
tepidum) 		3 / 3 LEU A  48
ASP A  51
TYR A  52
 None
 0.63A 4qc6B-1t6sA:
0.0		 4qc6B-1t6sA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 1t6s CONSERVED
HYPOTHETICAL PROTEIN
(Chlorobaculum
tepidum) 		5 / 11 ASN A  49
ASP A  46
GLU A  47
ASP A  51
ARG A   5
 None
NO3  A 407 ( 4.9A)
None
None
None
 1.14A 4urnA-1t6sA:
undetectable		 4urnA-1t6sA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 1t6s CONSERVED
HYPOTHETICAL PROTEIN
(Chlorobaculum
tepidum) 		5 / 11 ASP A  46
GLU A  47
ASP A  51
ARG A   5
ILE A  16
 NO3  A 407 ( 4.9A)
None
None
None
None
 1.17A 4urnA-1t6sA:
undetectable		 4urnA-1t6sA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 1t6s CONSERVED
HYPOTHETICAL PROTEIN
(Chlorobaculum
tepidum) 		5 / 11 ASN A  49
ASP A  46
GLU A  47
ASP A  51
ARG A   5
 None
NO3  A 407 ( 4.9A)
None
None
None
 1.19A 4urnB-1t6sA:
undetectable		 4urnB-1t6sA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 1t6s CONSERVED
HYPOTHETICAL PROTEIN
(Chlorobaculum
tepidum) 		5 / 11 ASN A  49
ASP A  46
GLU A  47
ASP A  51
ARG A   5
 None
NO3  A 407 ( 4.9A)
None
None
None
 1.23A 4urnC-1t6sA:
undetectable		 4urnC-1t6sA:
19.91