SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t6x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE
(Thermotoga
maritima) 		7 / 9 THR A 180
VAL A 213
GLU A 231
ARG A 255
LEU A 266
ILE A 270
ASP A 273
 ADP  A 294 (-3.7A)
None
None
None
None
None
None
 0.86A 1nb9A-1t6xA:
8.4		 1nb9A-1t6xA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE
(Thermotoga
maritima) 		4 / 4 HIS A  15
VAL A  18
THR A  37
LEU A  34
 None
 1.42A 1oq5A-1t6xA:
undetectable		 1oq5A-1t6xA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 11 HIS A  12
GLY A  14
HIS A  15
GLY A  99
VAL A 128
 None
 0.67A 1pg2A-1t6xA:
4.0		 1pg2A-1t6xA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 HIS A  12
GLY A  14
HIS A  15
GLY A  99
VAL A 128
 None
 0.89A 1qu2A-1t6xA:
2.9		 1qu2A-1t6xA:
15.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE
(Thermotoga
maritima) 		9 / 11 THR A 180
VAL A 197
ASN A 215
GLU A 231
ARG A 255
LYS A 258
LEU A 266
ILE A 270
ASP A 273
 ADP  A 294 (-3.7A)
None
None
None
None
None
None
None
None
 0.79A 1t6zA-1t6xA:
40.4		 1t6zA-1t6xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE
(Thermotoga
maritima) 		10 / 11 THR A 180
VAL A 197
VAL A 213
GLU A 231
ARG A 255
GLU A 257
LYS A 258
LEU A 266
ILE A 270
ASP A 273
 ADP  A 294 (-3.7A)
None
None
None
None
None
None
None
None
None
 0.49A 1t6zA-1t6xA:
40.4		 1t6zA-1t6xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE
(Thermotoga
maritima) 		7 / 11 THR A 180
VAL A 197
ASN A 215
GLU A 231
ARG A 255
LEU A 266
ASP A 273
 ADP  A 294 (-3.7A)
None
None
None
None
None
None
 0.85A 1t6zB-1t6xA:
38.3		 1t6zB-1t6xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE
(Thermotoga
maritima) 		9 / 11 THR A 180
VAL A 197
VAL A 213
GLU A 231
ARG A 255
GLU A 257
LEU A 266
ILE A 270
ASP A 273
 ADP  A 294 (-3.7A)
None
None
None
None
None
None
None
None
 0.71A 1t6zB-1t6xA:
38.3		 1t6zB-1t6xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE
(Thermotoga
maritima) 		9 / 11 THR A 180
VAL A 197
VAL A 213
GLU A 231
TYR A 233
ARG A 255
GLU A 257
LEU A 266
ASP A 273
 ADP  A 294 (-3.7A)
None
None
None
None
None
None
None
None
 0.50A 1t6zB-1t6xA:
38.3		 1t6zB-1t6xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 ARG A 103
VAL A  86
GLY A 119
 None
 0.58A 2avvE-1t6xA:
undetectable		 2avvE-1t6xA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 GLN A 131
LYS A 133
VAL A 135
 None
 0.92A 2jfaB-1t6xA:
undetectable		 2jfaB-1t6xA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE
(Thermotoga
maritima) 		4 / 7 VAL A  56
VAL A  60
LEU A  63
SER A  64
 None
 0.59A 3hs6B-1t6xA:
undetectable		 3hs6B-1t6xA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 GLU A 231
LYS A 229
ASN A 215
 None
 0.96A 4y1dA-1t6xA:
undetectable
4y1dD-1t6xA:
undetectable		 4y1dA-1t6xA:
21.21
4y1dD-1t6xA:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 LEU A 241
GLN A 244
LYS A 210
 ADP  A 294 (-3.5A)
None
None
 0.96A 6exiB-1t6xA:
undetectable		 6exiB-1t6xA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE
(Thermotoga
maritima) 		4 / 5 GLY A   6
HIS A  15
SER A 136
SER A 137
 None
 0.68A 6jmjA-1t6xA:
8.6		 6jmjA-1t6xA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 7 GLY A   6
PHE A   8
HIS A  15
SER A 136
SER A 137
 None
 0.87A 6jnhA-1t6xA:
8.6		 6jnhA-1t6xA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE
(Thermotoga
maritima) 		4 / 6 GLY A   6
HIS A  15
SER A 136
SER A 137
 None
 0.73A 6jogA-1t6xA:
8.6		 6jogA-1t6xA:
18.87