SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t70'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1t70 PHOSPHATASE
(Deinococcus
radiodurans) 		4 / 8 ARG A  26
VAL A   9
VAL A  34
LEU A  22
 None
 0.91A 1igxA-1t70A:
undetectable		 1igxA-1t70A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1t70 PHOSPHATASE
(Deinococcus
radiodurans) 		4 / 7 PHE A 144
THR A 172
VAL A 235
GLY A 234
 None
 0.91A 2a1mA-1t70A:
undetectable		 2a1mA-1t70A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1t70 PHOSPHATASE
(Deinococcus
radiodurans) 		5 / 9 PHE A 144
THR A 172
VAL A 235
GLY A 234
ILE A  33
 None
 1.15A 2a1oB-1t70A:
undetectable		 2a1oB-1t70A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1t70 PHOSPHATASE
(Deinococcus
radiodurans) 		5 / 9 PHE A 144
VAL A 235
GLY A 234
ASP A 146
ILE A  33
 None
 1.17A 2a1oB-1t70A:
undetectable		 2a1oB-1t70A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1t70 PHOSPHATASE
(Deinococcus
radiodurans) 		6 / 12 GLY A 195
ASP A   8
ASN A  35
VAL A  34
GLY A  14
ILE A   6
 None
 1.36A 2qakA-1t70A:
undetectable		 2qakA-1t70A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1t70 PHOSPHATASE
(Deinococcus
radiodurans) 		5 / 11 GLY A  11
GLY A  41
ALA A 230
GLU A 254
ALA A  49
 None
 1.06A 3g88A-1t70A:
undetectable		 3g88A-1t70A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1t70 PHOSPHATASE
(Deinococcus
radiodurans) 		5 / 11 GLY A  11
GLY A  41
ALA A 230
GLU A 254
ALA A  49
 None
 1.05A 3g88B-1t70A:
undetectable		 3g88B-1t70A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 1t70 PHOSPHATASE
(Deinococcus
radiodurans) 		4 / 8 GLY A 187
ILE A 170
PHE A  31
PHE A 239
 None
 1.05A 3ko0B-1t70A:
undetectable
3ko0J-1t70A:
undetectable		 3ko0B-1t70A:
15.94
3ko0J-1t70A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 1t70 PHOSPHATASE
(Deinococcus
radiodurans) 		4 / 8 GLY A 187
ILE A 170
PHE A  31
PHE A 239
 None
 1.05A 3ko0K-1t70A:
undetectable
3ko0S-1t70A:
undetectable		 3ko0K-1t70A:
15.94
3ko0S-1t70A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1t70 PHOSPHATASE
(Deinococcus
radiodurans) 		5 / 10 PHE A 144
GLY A 234
ASP A 146
ILE A  33
VAL A  34
 None
 1.14A 4jx1B-1t70A:
undetectable		 4jx1B-1t70A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1t70 PHOSPHATASE
(Deinococcus
radiodurans) 		5 / 12 GLY A 141
ILE A  25
GLY A 234
LEU A 237
THR A 111
 None
 1.17A 4zdyA-1t70A:
undetectable		 4zdyA-1t70A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 1t70 PHOSPHATASE
(Deinococcus
radiodurans) 		6 / 12 GLY A 198
ASN A 233
VAL A  34
LEU A  18
HIS A  21
LEU A  22
 None
 1.50A 5wy0A-1t70A:
undetectable		 5wy0A-1t70A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1t70 PHOSPHATASE
(Deinococcus
radiodurans) 		4 / 7 ASN A  65
HIS A  66
GLY A 205
ASN A  38
 None
 1.14A 5x7pA-1t70A:
2.1		 5x7pA-1t70A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1t70 PHOSPHATASE
(Deinococcus
radiodurans) 		4 / 7 HIS A  66
ASP A   8
GLY A 205
ASN A  38
 None
 0.94A 5x7pA-1t70A:
2.1		 5x7pA-1t70A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1t70 PHOSPHATASE
(Deinococcus
radiodurans) 		5 / 12 GLY A  11
GLY A  42
ILE A   6
GLY A 198
GLY A  14
 None
 0.87A 5zhmB-1t70A:
undetectable		 5zhmB-1t70A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 1t70 PHOSPHATASE
(Deinococcus
radiodurans) 		4 / 7 GLY A 195
HIS A  66
ASN A  38
GLY A 205
 None
 0.96A 6n7fA-1t70A:
0.3		 6n7fA-1t70A:
17.25