SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t8b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 1t8b PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG
(Aquifex
aeolicus) 		5 / 10 ALA A 101
ASP A  99
VAL A  27
ILE A  56
GLY A  52
 None
 1.20A 1d4sA-1t8bA:
undetectable		 1d4sA-1t8bA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 1t8b PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG
(Aquifex
aeolicus) 		4 / 8 GLU A 206
ASP A  93
ARG A  96
MET A  97
 None
 1.07A 1dtlA-1t8bA:
undetectable		 1dtlA-1t8bA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_B_KANB501_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1t8b PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG
(Aquifex
aeolicus) 		5 / 9 ASP A  93
GLY A  98
SER A 137
ASP A 156
ASP A 199
 None
 1.45A 1m4iB-1t8bA:
undetectable		 1m4iB-1t8bA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 1t8b PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG
(Aquifex
aeolicus) 		4 / 8 ASP A 160
HIS A 164
ASP A 157
GLU A 100
 None
 1.13A 3sg9B-1t8bA:
undetectable		 3sg9B-1t8bA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 1t8b PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG
(Aquifex
aeolicus) 		4 / 6 GLY A  98
ARG A 192
ILE A 197
LEU A  94
 None
 0.91A 4ac9C-1t8bA:
undetectable		 4ac9C-1t8bA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1t8b PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG
(Aquifex
aeolicus) 		4 / 6 GLY A  98
ARG A 192
ILE A 197
LEU A  94
 None
 0.88A 4acaC-1t8bA:
undetectable		 4acaC-1t8bA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1t8b PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG
(Aquifex
aeolicus) 		4 / 6 GLY A  98
ARG A 192
ILE A 197
LEU A  94
 None
 0.94A 4acbC-1t8bA:
undetectable		 4acbC-1t8bA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 1t8b PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG
(Aquifex
aeolicus) 		3 / 3 LEU A  94
MET A  23
ASP A 145
 None
 0.75A 4j7xB-1t8bA:
undetectable		 4j7xB-1t8bA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 1t8b PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG
(Aquifex
aeolicus) 		4 / 4 ILE A 104
ASN A 103
ILE A  50
VAL A  49
 None
 1.07A 4uy87-1t8bA:
undetectable		 4uy87-1t8bA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 1t8b PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG
(Aquifex
aeolicus) 		4 / 7 VAL A 134
GLN A  28
SER A 127
GLU A 128
 None
 1.00A 4zphA-1t8bA:
undetectable
4zphB-1t8bA:
undetectable		 4zphA-1t8bA:
19.22
4zphB-1t8bA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1t8b PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG
(Aquifex
aeolicus) 		5 / 8 ILE A  63
VAL A  49
ILE A  31
ILE A 197
ASP A  99
 None
 1.46A 5hi2A-1t8bA:
2.2		 5hi2A-1t8bA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1t8b PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG
(Aquifex
aeolicus) 		5 / 8 ILE A 129
VAL A 130
VAL A  91
ILE A  63
ILE A  21
 None
 1.46A 5hi2A-1t8bA:
2.2		 5hi2A-1t8bA:
20.47