SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t8h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		5 / 12 GLU A 220
ASP A 217
ILE A 175
ILE A 128
ALA A 143
 None
 0.87A 1kijB-1t8hA:
undetectable		 1kijB-1t8hA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 137
LEU A 118
ILE A  84
GLU A 164
 None
 1.06A 1n13I-1t8hA:
undetectable
1n13L-1t8hA:
undetectable		 1n13I-1t8hA:
10.70
1n13L-1t8hA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 108
HIS A 142
HIS A  80
ILE A  84
GLY A 144
 None
None
None
None
BME  A 302 (-3.3A)
 1.02A 1utdL-1t8hA:
undetectable
1utdM-1t8hA:
undetectable		 1utdL-1t8hA:
13.00
1utdM-1t8hA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 267
GLY A 268
GLY A 115
LEU A  66
ALA A  23
 None
 0.99A 2fk8A-1t8hA:
undetectable		 2fk8A-1t8hA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		4 / 7 GLU A   8
TRP A  65
MET A 263
GLY A  26
 None
 1.26A 2hs1B-1t8hA:
undetectable		 2hs1B-1t8hA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		4 / 4 VAL A 138
THR A 111
VAL A 116
GLY A 115
 None
 1.18A 2p2fB-1t8hA:
undetectable		 2p2fB-1t8hA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		6 / 12 LEU A 140
GLY A  26
ALA A  25
GLY A  16
ILE A   4
ILE A 267
 None
 1.49A 3bvbB-1t8hA:
undetectable		 3bvbB-1t8hA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 140
PHE A   5
ALA A  23
ALA A  17
GLY A 176
 None
 1.13A 3c6gB-1t8hA:
undetectable		 3c6gB-1t8hA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 224
GLU A 220
ASP A 217
SER A 202
 None
 1.47A 3dzgA-1t8hA:
undetectable		 3dzgA-1t8hA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		6 / 10 LEU A 140
GLY A  26
ALA A  25
GLY A  16
ILE A   4
ILE A 267
 None
 1.42A 3ekvA-1t8hA:
undetectable		 3ekvA-1t8hA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A  95
ALA A  96
LEU A 120
VAL A 116
 None
 0.60A 3em6A-1t8hA:
undetectable		 3em6A-1t8hA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		5 / 11 LEU A 264
LEU A  62
LEU A 117
GLY A  95
LEU A  46
 None
None
None
None
BME  A 301 (-4.4A)
 1.27A 3hm1B-1t8hA:
undetectable		 3hm1B-1t8hA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		6 / 9 LEU A 140
GLY A  26
ALA A  25
GLY A  16
ILE A   4
ILE A 267
 None
 1.47A 3nujB-1t8hA:
undetectable		 3nujB-1t8hA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		4 / 5 PHE A 130
ALA A 143
THR A 148
LEU A 226
 None
 1.14A 3t3zC-1t8hA:
undetectable		 3t3zC-1t8hA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		4 / 5 ASP A 112
THR A 111
LEU A 137
GLU A 164
 None
 1.43A 4a3pA-1t8hA:
undetectable		 4a3pA-1t8hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		6 / 12 LEU A 140
GLY A  26
ALA A  25
GLY A  16
ILE A   4
ILE A 267
 None
 1.46A 4jecA-1t8hA:
undetectable		 4jecA-1t8hA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		3 / 3 SER A 239
ALA A 174
VAL A 173
 None
 0.60A 4o2bC-1t8hA:
undetectable		 4o2bC-1t8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		3 / 3 VAL A 116
ALA A 114
PHE A  68
 None
 0.92A 4olbA-1t8hA:
undetectable		 4olbA-1t8hA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		4 / 8 HIS A 253
ASP A 256
ARG A 255
ARG A 254
 None
 1.19A 4uhxA-1t8hA:
undetectable		 4uhxA-1t8hA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		3 / 3 VAL A 126
ALA A 141
PHE A 122
 None
 0.88A 4w5nA-1t8hA:
undetectable		 4w5nA-1t8hA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 257
ASP A 256
ARG A 255
 None
 0.64A 4wq4B-1t8hA:
undetectable		 4wq4B-1t8hA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		3 / 3 SER A 239
ALA A 174
VAL A 173
 None
 0.54A 4x1iA-1t8hA:
undetectable		 4x1iA-1t8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		3 / 3 SER A 239
ALA A 174
VAL A 173
 None
 0.60A 4x20C-1t8hA:
undetectable		 4x20C-1t8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		3 / 3 SER A 239
ALA A 174
VAL A 173
 None
 0.56A 5eypA-1t8hA:
undetectable		 5eypA-1t8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		5 / 11 LEU A  62
LEU A 118
GLY A 268
TYR A 129
ALA A 265
 None
 1.35A 5fctA-1t8hA:
undetectable		 5fctA-1t8hA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		3 / 3 SER A 239
ALA A 174
VAL A 173
 None
 0.50A 5xiwC-1t8hA:
undetectable		 5xiwC-1t8hA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		4 / 5 LEU A 117
THR A  28
ARG A  60
ARG A  52
 None
 1.26A 6ew0B-1t8hA:
0.0		 6ew0B-1t8hA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		4 / 5 LEU A 117
THR A  28
ARG A  60
ARG A  52
 None
 1.26A 6ew0D-1t8hA:
0.0		 6ew0D-1t8hA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		4 / 5 LEU A 117
THR A  28
ARG A  60
ARG A  52
 None
 1.26A 6ew0H-1t8hA:
0.0		 6ew0H-1t8hA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		4 / 5 LEU A 117
THR A  28
ARG A  60
ARG A  52
 None
 1.26A 6ew0I-1t8hA:
0.0		 6ew0I-1t8hA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A 217
LEU A 216
ARG A 254
 None
 0.88A 7dfrA-1t8hA:
undetectable		 7dfrA-1t8hA:
21.32