SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t8q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		3 / 3 GLU A  63
TYR A 169
PHE A 344
 MG  A1601 ( 2.7A)
None
None
 0.93A 1eqbB-1t8qA:
undetectable		 1eqbB-1t8qA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		3 / 3 GLU A  63
TYR A 169
PHE A 344
 MG  A1601 ( 2.7A)
None
None
 0.92A 1eqbA-1t8qA:
undetectable		 1eqbA-1t8qA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		3 / 3 GLU A  63
TYR A 169
PHE A 344
 MG  A1601 ( 2.7A)
None
None
 0.92A 1eqbD-1t8qA:
undetectable		 1eqbD-1t8qA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		3 / 3 GLU A  63
TYR A 169
PHE A 344
 MG  A1601 ( 2.7A)
None
None
 0.92A 1eqbC-1t8qA:
undetectable		 1eqbC-1t8qA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		4 / 7 PHE A 148
VAL A 205
VAL A 155
ILE A 152
 None
 0.83A 1p7rA-1t8qA:
undetectable		 1p7rA-1t8qA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		4 / 6 ASP A  65
LEU A  66
VAL A  67
ILE A 185
 MG  A1601 ( 2.7A)
None
None
None
 0.89A 1s9qA-1t8qA:
undetectable		 1s9qA-1t8qA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		4 / 7 PHE A 148
VAL A 205
VAL A 155
ILE A 152
 None
 0.89A 1t87B-1t8qA:
undetectable		 1t87B-1t8qA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		4 / 8 PHE A 148
VAL A 205
VAL A 155
ILE A 152
 None
 0.77A 2a1mB-1t8qA:
undetectable		 2a1mB-1t8qA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		5 / 10 ALA A  52
ALA A  54
LEU A  62
LEU A 158
VAL A 155
 None
 1.20A 2bxeA-1t8qA:
undetectable		 2bxeA-1t8qA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		4 / 7 TYR A 238
ASP A 280
TYR A 281
TYR A 323
 None
 1.41A 2bytA-1t8qA:
undetectable		 2bytA-1t8qA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		4 / 7 TYR A 238
ASP A 280
TYR A 281
TYR A 323
 None
 1.42A 2bytD-1t8qA:
undetectable		 2bytD-1t8qA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		5 / 12 GLY A  38
HIS A  36
THR A 345
ALA A  52
ALA A  59
 None
GOL  A1605 (-3.7A)
None
None
None
 0.99A 2gluB-1t8qA:
undetectable		 2gluB-1t8qA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		5 / 11 LEU A 207
ILE A 218
MET A 226
LEU A 109
VAL A  75
 None
 1.32A 2n27A-1t8qA:
undetectable		 2n27A-1t8qA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_D_LEUD1883_0
(AMINOACYL-TRNA
SYNTHETASE)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		4 / 5 TYR A 238
ASP A 280
TYR A 281
TYR A 323
 None
 1.30A 2v0gD-1t8qA:
1.2		 2v0gD-1t8qA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		3 / 3 GLU A 171
HIS A  36
GLU A  63
 MG  A1601 ( 2.9A)
GOL  A1605 (-3.7A)
MG  A1601 ( 2.7A)
 0.61A 2x45B-1t8qA:
undetectable		 2x45B-1t8qA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		3 / 3 GLU A 171
HIS A  36
GLU A  63
 MG  A1601 ( 2.9A)
GOL  A1605 (-3.7A)
MG  A1601 ( 2.7A)
 0.64A 2x45C-1t8qA:
undetectable		 2x45C-1t8qA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		5 / 12 GLY A 339
ALA A 333
HIS A 311
LEU A 343
VAL A 315
 None
 0.93A 2yqzB-1t8qA:
undetectable		 2yqzB-1t8qA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		4 / 5 TYR A 273
ILE A 236
TYR A 258
THR A 239
 None
 1.46A 3dgqA-1t8qA:
0.0		 3dgqA-1t8qA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		3 / 3 LEU A 232
LEU A 215
ARG A 217
 None
 0.59A 3hcnB-1t8qA:
2.4		 3hcnB-1t8qA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		3 / 3 ASP A 202
LYS A 201
ASP A 203
 None
 0.86A 4a7tA-1t8qA:
0.0		 4a7tA-1t8qA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		4 / 8 PHE A 148
VAL A 205
VAL A 155
ILE A 152
 None
 0.93A 4l4cB-1t8qA:
undetectable		 4l4cB-1t8qA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		3 / 3 ARG A  37
HIS A  46
SER A  40
 GOL  A1605 (-4.2A)
None
None
 0.87A 4mjwA-1t8qA:
undetectable
4mjwB-1t8qA:
undetectable		 4mjwA-1t8qA:
19.71
4mjwB-1t8qA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		3 / 3 SER A  40
ARG A  37
HIS A  46
 None
GOL  A1605 (-4.2A)
None
 0.86A 4mjwA-1t8qA:
undetectable
4mjwB-1t8qA:
undetectable		 4mjwA-1t8qA:
19.71
4mjwB-1t8qA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		5 / 12 VAL A  85
TYR A 102
ILE A 105
GLN A 180
HIS A  80
 None
 1.37A 4xucA-1t8qA:
undetectable		 4xucA-1t8qA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		5 / 8 ARG A 144
ASP A  83
LEU A  82
PHE A  92
TYR A  81
 None
 1.47A 5nooD-1t8qA:
undetectable		 5nooD-1t8qA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		4 / 6 GLN A 208
VAL A  76
LEU A 215
PRO A 175
 GOL  A1605 ( 4.5A)
None
None
None
 1.20A 6brdB-1t8qA:
undetectable		 6brdB-1t8qA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		4 / 6 TYR A 313
ASP A  65
GLU A 171
ALA A 237
 GOL  A1605 (-3.8A)
MG  A1601 ( 2.7A)
MG  A1601 ( 2.9A)
None
 0.99A 6djzB-1t8qA:
undetectable		 6djzB-1t8qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC
(Escherichia
coli) 		4 / 6 LEU A 215
TYR A 313
ASP A  65
GLU A 171
 None
GOL  A1605 (-3.8A)
MG  A1601 ( 2.7A)
MG  A1601 ( 2.9A)
 1.06A 6djzC-1t8qA:
undetectable		 6djzC-1t8qA:
22.22