SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t8t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1t8t HEPARAN SULFATE
D-GLUCOSAMINYL
3-O-SULFOTRANSFERASE
3A1
(Homo
sapiens) 		4 / 8 TYR A 395
TYR A 387
LEU A 392
GLU A 385
 None
 1.00A 1i7zA-1t8tA:
undetectable		 1i7zA-1t8tA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 1t8t HEPARAN SULFATE
D-GLUCOSAMINYL
3-O-SULFOTRANSFERASE
3A1
(Homo
sapiens) 		3 / 3 ARG A 248
VAL A 379
THR A 270
 None
 0.57A 2nnkA-1t8tA:
undetectable		 2nnkA-1t8tA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 1t8t HEPARAN SULFATE
D-GLUCOSAMINYL
3-O-SULFOTRANSFERASE
3A1
(Homo
sapiens) 		5 / 9 LEU A 352
ILE A 336
ALA A 320
GLY A 164
LEU A 315
 None
None
None
A3P  A1302 (-3.3A)
None
 1.14A 2v0mB-1t8tA:
undetectable		 2v0mB-1t8tA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 1t8t HEPARAN SULFATE
D-GLUCOSAMINYL
3-O-SULFOTRANSFERASE
3A1
(Homo
sapiens) 		3 / 3 ARG A 248
VAL A 379
THR A 270
 None
 0.59A 3k4vA-1t8tA:
undetectable		 3k4vA-1t8tA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 1t8t HEPARAN SULFATE
D-GLUCOSAMINYL
3-O-SULFOTRANSFERASE
3A1
(Homo
sapiens) 		3 / 3 ARG A 248
VAL A 379
THR A 270
 None
 0.63A 3k4vD-1t8tA:
0.0		 3k4vD-1t8tA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1t8t HEPARAN SULFATE
D-GLUCOSAMINYL
3-O-SULFOTRANSFERASE
3A1
(Homo
sapiens) 		5 / 8 VAL A 326
LEU A 323
ILE A 239
VAL A 310
LEU A 315
 None
 1.04A 3kp6A-1t8tA:
undetectable
3kp6B-1t8tA:
undetectable		 3kp6A-1t8tA:
20.15
3kp6B-1t8tA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 1t8t HEPARAN SULFATE
D-GLUCOSAMINYL
3-O-SULFOTRANSFERASE
3A1
(Homo
sapiens) 		3 / 3 ARG A 248
VAL A 379
THR A 270
 None
 0.62A 3ndtA-1t8tA:
undetectable		 3ndtA-1t8tA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 1t8t HEPARAN SULFATE
D-GLUCOSAMINYL
3-O-SULFOTRANSFERASE
3A1
(Homo
sapiens) 		3 / 3 ARG A 248
VAL A 379
THR A 270
 None
 0.70A 3nduD-1t8tA:
undetectable		 3nduD-1t8tA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1t8t HEPARAN SULFATE
D-GLUCOSAMINYL
3-O-SULFOTRANSFERASE
3A1
(Homo
sapiens) 		3 / 3 ARG A 248
VAL A 379
THR A 270
 None
 0.64A 3pwrA-1t8tA:
undetectable		 3pwrA-1t8tA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1t8t HEPARAN SULFATE
D-GLUCOSAMINYL
3-O-SULFOTRANSFERASE
3A1
(Homo
sapiens) 		4 / 8 ILE A 156
TYR A 199
LEU A 196
PHE A 187
 None
 0.98A 3rqwI-1t8tA:
undetectable
3rqwJ-1t8tA:
undetectable		 3rqwI-1t8tA:
22.22
3rqwJ-1t8tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 1t8t HEPARAN SULFATE
D-GLUCOSAMINYL
3-O-SULFOTRANSFERASE
3A1
(Homo
sapiens) 		3 / 3 ARG A 248
VAL A 379
THR A 270
 None
 0.64A 3tl9A-1t8tA:
undetectable		 3tl9A-1t8tA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 1t8t HEPARAN SULFATE
D-GLUCOSAMINYL
3-O-SULFOTRANSFERASE
3A1
(Homo
sapiens) 		4 / 5 THR A 165
ILE A 157
LYS A 215
GLU A 214
 A3P  A1302 (-2.9A)
None
None
None
 1.37A 4ac9C-1t8tA:
3.4		 4ac9C-1t8tA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1t8t HEPARAN SULFATE
D-GLUCOSAMINYL
3-O-SULFOTRANSFERASE
3A1
(Homo
sapiens) 		4 / 5 THR A 165
ILE A 157
LYS A 215
GLU A 214
 A3P  A1302 (-2.9A)
None
None
None
 1.43A 4acbC-1t8tA:
5.1		 4acbC-1t8tA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1t8t HEPARAN SULFATE
D-GLUCOSAMINYL
3-O-SULFOTRANSFERASE
3A1
(Homo
sapiens) 		3 / 3 ASP A 244
VAL A 241
ASN A 391
 None
 0.78A 4lmnA-1t8tA:
undetectable		 4lmnA-1t8tA:
20.92