SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t8w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		4 / 8 ARG A 415
LEU A 331
ILE A 288
VAL A 330
 None
 0.76A 1d4sB-1t8wA:
undetectable		 1d4sB-1t8wA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		4 / 8 ARG A 178
VAL A 179
SER A 182
ASP A 290
 None
 1.24A 1hwkA-1t8wA:
undetectable		 1hwkA-1t8wA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 12 GLY A 307
MET A 404
GLU A 405
SER A 427
ASP A 428
 None
 0.61A 1jdvE-1t8wA:
24.0
1jdvF-1t8wA:
24.1		 1jdvE-1t8wA:
19.92
1jdvF-1t8wA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 9 GLY A 307
MET A 404
GLU A 405
SER A 427
ASP A 428
 None
 0.54A 1pk7A-1t8wA:
24.5		 1pk7A-1t8wA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		4 / 8 GLY A 307
MET A 404
GLU A 405
SER A 427
 None
 0.60A 1pk7B-1t8wA:
24.5		 1pk7B-1t8wA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 10 GLY A 307
MET A 404
GLU A 405
SER A 427
ASP A 428
 None
 0.34A 1pk7C-1t8wA:
25.1		 1pk7C-1t8wA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 10 GLY A 307
MET A 404
GLU A 405
SER A 427
ASP A 428
 None
 0.52A 1pk9A-1t8wA:
24.5		 1pk9A-1t8wA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 9 GLY A 307
MET A 404
GLU A 405
SER A 427
ASP A 428
 None
 0.47A 1pk9B-1t8wA:
24.4		 1pk9B-1t8wA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 11 GLY A 307
MET A 404
GLU A 405
SER A 427
ASP A 428
 None
 0.44A 1pk9C-1t8wA:
24.5		 1pk9C-1t8wA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 10 GLY A 307
MET A 404
GLU A 405
SER A 427
ASP A 428
 None
 0.49A 1pw7A-1t8wA:
24.5		 1pw7A-1t8wA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		4 / 5 ILE A 273
ARG A 464
TRP A 216
LEU A 202
 None
 1.30A 1s8fA-1t8wA:
3.4
1s8fB-1t8wA:
4.3		 1s8fA-1t8wA:
18.45
1s8fB-1t8wA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		3 / 3 ARG A 296
VAL A 299
TRP A 300
 None
 1.20A 1vagA-1t8wA:
undetectable		 1vagA-1t8wA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 10 GLY A 307
THR A 378
MET A 404
GLU A 405
SER A 427
 None
 0.60A 1z35A-1t8wA:
24.0		 1z35A-1t8wA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		4 / 7 ALA A 407
THR A 408
ALA A 411
PRO A 282
 None
 0.98A 2ql8A-1t8wA:
undetectable
2ql8B-1t8wA:
undetectable		 2ql8A-1t8wA:
13.79
2ql8B-1t8wA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		4 / 7 THR A 204
ILE A 303
GLY A 304
ILE A 449
 None
 0.80A 2y7wC-1t8wA:
undetectable		 2y7wC-1t8wA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 12 LEU A 453
ILE A 460
ILE A 457
ILE A 266
PHE A 213
 None
 0.98A 2ygoA-1t8wA:
undetectable		 2ygoA-1t8wA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 12 GLY A 236
GLY A 235
ALA A 254
PRO A 193
ALA A 249
 None
 0.92A 3jb2A-1t8wA:
undetectable		 3jb2A-1t8wA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		4 / 8 ALA A 176
VAL A 179
ASP A 180
LEU A 183
 None
 0.79A 3roxA-1t8wA:
undetectable		 3roxA-1t8wA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 12 LEU A 351
THR A 204
LEU A 453
ILE A 273
HIS A 264
 None
 0.97A 3sp9A-1t8wA:
0.0		 3sp9A-1t8wA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 11 GLY A 307
MET A 404
GLU A 405
SER A 427
ASP A 428
 None
 0.49A 3uawA-1t8wA:
25.0		 3uawA-1t8wA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 12 SER A  56
ARG A  47
GLN A 118
ILE A 121
SER A  24
 None
 1.34A 4b3aA-1t8wA:
undetectable		 4b3aA-1t8wA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 11 GLY A 307
MET A 404
GLU A 405
SER A 427
ASP A 428
 None
 0.60A 4d9hA-1t8wA:
24.0		 4d9hA-1t8wA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 9 GLY A 307
MET A 404
GLU A 405
SER A 427
ASP A 428
 None
 0.74A 4da6A-1t8wA:
23.6		 4da6A-1t8wA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 11 GLY A 307
MET A 404
GLU A 405
SER A 427
ASP A 428
 None
 0.61A 4danA-1t8wA:
23.6		 4danA-1t8wA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 12 GLY A 307
MET A 404
GLU A 405
SER A 427
ASP A 428
 None
 0.58A 4danA-1t8wA:
23.6
4danB-1t8wA:
23.8		 4danA-1t8wA:
20.37
4danB-1t8wA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		4 / 6 LEU A 295
LEU A 292
ILE A 288
THR A 274
 None
 1.01A 4do3B-1t8wA:
undetectable		 4do3B-1t8wA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 12 LEU A 231
ALA A 234
LEU A 275
ASN A 277
ASP A 211
 None
 1.28A 4qckA-1t8wA:
undetectable		 4qckA-1t8wA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 11 ILE A 341
ALA A 407
ASP A 328
SER A 397
THR A 408
 None
 1.27A 4qi9C-1t8wA:
undetectable		 4qi9C-1t8wA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		3 / 3 VAL A 126
PHE A 146
ARG A  47
 None
 0.98A 4xr4B-1t8wA:
undetectable		 4xr4B-1t8wA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		4 / 6 PHE A 416
LEU A 292
PRO A 297
ARG A 415
 None
 1.32A 4yv5B-1t8wA:
undetectable		 4yv5B-1t8wA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		4 / 6 PHE A 416
LEU A 292
PRO A 297
ARG A 415
 None
 1.32A 4yv5A-1t8wA:
undetectable		 4yv5A-1t8wA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 12 ILE A 341
GLY A 413
MET A 302
GLU A 405
THR A 377
 None
 1.45A 5fhzD-1t8wA:
undetectable		 5fhzD-1t8wA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		3 / 3 ARG A 177
THR A  86
ASP A 175
 None
 0.89A 5g5gA-1t8wA:
0.8
5g5gB-1t8wA:
undetectable		 5g5gA-1t8wA:
20.13
5g5gB-1t8wA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 12 ALA A  27
PRO A 147
PHE A  52
THR A  86
TYR A 125
 None
 1.31A 5hfjB-1t8wA:
undetectable		 5hfjB-1t8wA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 12 ALA A  27
PRO A 147
PHE A  52
THR A  86
TYR A 125
 None
 1.36A 5hfjG-1t8wA:
2.3		 5hfjG-1t8wA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 12 ALA A  27
PRO A 147
PHE A  52
THR A  86
TYR A 125
 None
 1.31A 5hfjH-1t8wA:
undetectable		 5hfjH-1t8wA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 12 ILE A 341
ALA A 407
ASP A 328
SER A 397
THR A 408
 None
 1.19A 5hi6B-1t8wA:
undetectable		 5hi6B-1t8wA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		5 / 12 LEU A 202
LEU A 275
ALA A 262
SER A 232
LEU A 231
 None
 1.21A 5mwyA-1t8wA:
undetectable		 5mwyA-1t8wA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		4 / 7 ARG A 177
ILE A 121
PHE A  93
THR A  84
 None
 0.92A 5vc0A-1t8wA:
undetectable		 5vc0A-1t8wA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		4 / 7 GLN A 271
GLY A 272
ILE A 460
GLN A 454
 None
 1.00A 5vlmC-1t8wA:
0.0		 5vlmC-1t8wA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		4 / 8 GLN A 271
GLY A 272
ILE A 460
GLN A 454
 None
 0.88A 5vlmD-1t8wA:
undetectable		 5vlmD-1t8wA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 1t8w AMP NUCLEOSIDASE
(Escherichia
coli) 		3 / 3 ILE A 239
THR A 240
PRO A 246
 None
 0.48A 6ncsA-1t8wA:
undetectable		 6ncsA-1t8wA:
21.89