SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t90'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 ALA A 208
HIS A 209
VAL A 212
 None
NAD  A1490 (-3.5A)
NAD  A1490 (-4.5A)
 0.50A 1lqtB-1t90A:
2.8		 1lqtB-1t90A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 ALA A 208
HIS A 209
VAL A 212
 None
NAD  A1490 (-3.5A)
NAD  A1490 (-4.5A)
 0.51A 1lquB-1t90A:
2.5		 1lquB-1t90A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 LYS A 397
ILE A 429
THR A 416
 None
 0.79A 1rx3A-1t90A:
undetectable		 1rx3A-1t90A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 PHE A 163
LEU A  86
PHE A  75
LEU A 191
LEU A 184
 None
 1.11A 1xdkB-1t90A:
undetectable		 1xdkB-1t90A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 5 LEU A 216
GLY A 240
ILE A 224
PHE A 226
 None
None
None
NAD  A1490 (-4.7A)
 0.85A 1xf1A-1t90A:
undetectable		 1xf1A-1t90A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 6 LEU A 216
GLY A 240
ILE A 224
PHE A 226
 None
None
None
NAD  A1490 (-4.7A)
 0.89A 1xf1B-1t90A:
undetectable		 1xf1B-1t90A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 5 PRO A 443
GLY A 411
ASN A 410
GLY A 451
 None
None
NAD  A1490 (-3.4A)
None
 0.67A 1zlqA-1t90A:
undetectable		 1zlqA-1t90A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 11 LEU A 191
VAL A 105
GLY A 108
CYH A 160
LEU A  86
 None
 1.27A 2bxeA-1t90A:
0.0		 2bxeA-1t90A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 GLY A 207
ALA A 208
GLY A 214
ILE A 215
VAL A 232
 None
None
None
None
NAD  A1490 (-4.0A)
 0.95A 2o4sA-1t90A:
undetectable		 2o4sA-1t90A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 7 VAL A 290
ILE A 272
ALA A 276
THR A 257
 None
 0.80A 2xrzB-1t90A:
undetectable		 2xrzB-1t90A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 ALA A 403
ILE A 400
GLU A 382
ALA A 253
ASP A 430
 None
None
NAD  A1490 (-2.9A)
NAD  A1490 ( 4.7A)
None
 1.26A 3axtA-1t90A:
2.3		 3axtA-1t90A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 9 THR A 268
LEU A 396
ILE A 400
ILE A 272
GLY A 439
 None
 1.19A 3cv9A-1t90A:
undetectable		 3cv9A-1t90A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 ILE A 149
GLY A 148
GLY A 147
ALA A 223
PRO A 159
 NAD  A1490 (-4.9A)
None
None
None
None
 0.97A 3jayA-1t90A:
undetectable		 3jayA-1t90A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 GLY A 432
PHE A 408
SER A 406
ALA A 412
ASN A 255
 None
 1.30A 3t7sA-1t90A:
3.7		 3t7sA-1t90A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 GLY A 432
PHE A 408
SER A 406
ALA A 412
ASN A 255
 None
 1.28A 3t7sB-1t90A:
3.7		 3t7sB-1t90A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 GLY A 432
PHE A 408
SER A 406
ALA A 412
ASN A 255
 None
 1.31A 3t7sD-1t90A:
3.6		 3t7sD-1t90A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 11 ARG A 334
PHE A 384
GLY A 252
PRO A 151
ASN A  94
 None
NAD  A1490 (-3.7A)
NAD  A1490 (-3.4A)
NAD  A1490 (-4.6A)
None
 1.48A 3v3nA-1t90A:
2.7		 3v3nA-1t90A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 11 ILE A 429
ALA A 431
GLY A 432
GLY A 252
HIS A 256
 None
None
None
NAD  A1490 (-3.4A)
None
 1.15A 4e47A-1t90A:
undetectable		 4e47A-1t90A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 11 ILE A 429
ALA A 431
GLY A 432
GLY A 252
HIS A 256
 None
None
None
NAD  A1490 (-3.4A)
None
 1.16A 4e47B-1t90A:
undetectable		 4e47B-1t90A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 11 ILE A 429
ALA A 431
GLY A 432
GLY A 252
HIS A 256
 None
None
None
NAD  A1490 (-3.4A)
None
 1.12A 4e47C-1t90A:
undetectable		 4e47C-1t90A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 LYS A 397
ILE A 429
THR A 416
 None
 0.83A 4gh8A-1t90A:
undetectable		 4gh8A-1t90A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 GLY A 252
ALA A 409
LYS A 453
SER A 455
 NAD  A1490 (-3.4A)
None
None
None
 0.88A 4hyfC-1t90A:
undetectable		 4hyfC-1t90A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 11 ILE A 429
ALA A 431
GLY A 432
GLY A 252
HIS A 256
 None
None
None
NAD  A1490 (-3.4A)
None
 1.18A 4jdsA-1t90A:
undetectable		 4jdsA-1t90A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 11 ILE A 429
ALA A 431
GLY A 432
GLY A 252
HIS A 256
 None
None
None
NAD  A1490 (-3.4A)
None
 1.17A 4jdsB-1t90A:
undetectable		 4jdsB-1t90A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 11 ILE A 429
ALA A 431
GLY A 432
GLY A 252
HIS A 256
 None
None
None
NAD  A1490 (-3.4A)
None
 1.13A 4jdsC-1t90A:
undetectable		 4jdsC-1t90A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 ILE A 429
ALA A 431
GLY A 432
GLY A 252
HIS A 256
 None
None
None
NAD  A1490 (-3.4A)
None
 1.12A 4jlgA-1t90A:
undetectable		 4jlgA-1t90A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 11 ILE A 429
ALA A 431
GLY A 432
GLY A 252
HIS A 256
 None
None
None
NAD  A1490 (-3.4A)
None
 1.19A 5ayfA-1t90A:
undetectable		 5ayfA-1t90A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 VAL A 326
PRO A 325
ALA A 280
PHE A 384
ASN A 331
 None
None
None
NAD  A1490 (-3.7A)
None
 1.20A 5hgcA-1t90A:
undetectable		 5hgcA-1t90A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 11 TYR A 471
VAL A 227
ILE A 215
ILE A 221
PHE A 470
 None
NAD  A1490 (-4.7A)
None
None
None
 1.12A 5hw8E-1t90A:
undetectable		 5hw8E-1t90A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 ILE A  46
THR A 185
ALA A  54
SER A 225
ILE A 224
 None
 1.15A 5iwuA-1t90A:
0.0		 5iwuA-1t90A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 LEU A 260
LEU A 414
ILE A 400
ALA A 399
GLU A 398
 None
 1.12A 5v0vA-1t90A:
undetectable		 5v0vA-1t90A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 6 ARG A   5
LYS A   6
LEU A   7
LEU A 183
 None
 1.13A 5w97C-1t90A:
2.2
5w97J-1t90A:
undetectable		 5w97C-1t90A:
18.74
5w97J-1t90A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 7 ILE A 368
GLN A 305
ILE A 272
THR A 268
 None
 0.90A 6cduF-1t90A:
undetectable
6cduG-1t90A:
undetectable		 6cduF-1t90A:
20.58
6cduG-1t90A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 LEU A  72
ASN A 463
LEU A 121
 None
 0.63A 6exiA-1t90A:
4.6		 6exiA-1t90A:
13.88