SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t9h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 1t9h PROBABLE GTPASE ENGC
(Bacillus
subtilis) 		5 / 9 ILE A 109
LEU A 228
GLY A 224
ALA A  81
LEU A  83
 None
 0.92A 1e7bA-1t9hA:
undetectable		 1e7bA-1t9hA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1t9h PROBABLE GTPASE ENGC
(Bacillus
subtilis) 		3 / 3 ASP A 153
ASN A 182
THR A 214
 None
 0.72A 2pymB-1t9hA:
undetectable		 2pymB-1t9hA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1t9h PROBABLE GTPASE ENGC
(Bacillus
subtilis) 		3 / 3 ASP A 153
ASN A 182
THR A 214
 None
 0.77A 2q63B-1t9hA:
undetectable		 2q63B-1t9hA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 1t9h PROBABLE GTPASE ENGC
(Bacillus
subtilis) 		4 / 8 PHE A  92
THR A 126
ILE A 130
THR A 129
 None
 0.98A 3bpxA-1t9hA:
0.0
3bpxB-1t9hA:
0.0		 3bpxA-1t9hA:
20.98
3bpxB-1t9hA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 1t9h PROBABLE GTPASE ENGC
(Bacillus
subtilis) 		5 / 12 GLY A 176
GLY A 174
SER A  86
VAL A  82
SER A 179
 None
 1.03A 3dlcA-1t9hA:
undetectable		 3dlcA-1t9hA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1t9h PROBABLE GTPASE ENGC
(Bacillus
subtilis) 		3 / 3 TYR A 142
ASP A  98
ASP A 282
 ACT  A 416 (-3.7A)
None
None
 0.83A 3ou6B-1t9hA:
2.2		 3ou6B-1t9hA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 1t9h PROBABLE GTPASE ENGC
(Bacillus
subtilis) 		4 / 6 THR A  67
CYH A  76
ASP A  46
ILE A  63
 None
 1.43A 3w9tB-1t9hA:
0.0		 3w9tB-1t9hA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 1t9h PROBABLE GTPASE ENGC
(Bacillus
subtilis) 		4 / 6 THR A  67
CYH A  76
GLY A  45
ASP A  46
 None
 1.34A 3w9tE-1t9hA:
undetectable		 3w9tE-1t9hA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 1t9h PROBABLE GTPASE ENGC
(Bacillus
subtilis) 		3 / 3 ARG A 138
ASP A 128
GLN A 124
 None
 0.83A 4azsA-1t9hA:
undetectable		 4azsA-1t9hA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1t9h PROBABLE GTPASE ENGC
(Bacillus
subtilis) 		5 / 12 ILE A 140
VAL A 104
PHE A  85
ILE A 113
PHE A  92
 None
 1.28A 4fglA-1t9hA:
2.7
4fglB-1t9hA:
undetectable		 4fglA-1t9hA:
22.78
4fglB-1t9hA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 1t9h PROBABLE GTPASE ENGC
(Bacillus
subtilis) 		5 / 12 THR A 241
PHE A 242
PHE A 287
TYR A 137
ILE A 113
 None
 1.10A 4g1bA-1t9hA:
4.4		 4g1bA-1t9hA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 1t9h PROBABLE GTPASE ENGC
(Bacillus
subtilis) 		5 / 12 THR A 241
PHE A 242
PHE A 287
TYR A 137
ILE A 113
 None
 1.11A 4g1bD-1t9hA:
4.6		 4g1bD-1t9hA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 1t9h PROBABLE GTPASE ENGC
(Bacillus
subtilis) 		3 / 3 LEU A  60
MET A   1
TYR A  47
 None
 0.71A 4p6xG-1t9hA:
undetectable		 4p6xG-1t9hA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 1t9h PROBABLE GTPASE ENGC
(Bacillus
subtilis) 		5 / 10 TYR A 137
ILE A 113
PHE A 100
LEU A 101
ALA A  95
 None
None
None
None
CA  A 415 ( 4.4A)
 1.20A 5y7pG-1t9hA:
undetectable		 5y7pG-1t9hA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 1t9h PROBABLE GTPASE ENGC
(Bacillus
subtilis) 		4 / 7 ASP A  46
LEU A  43
ILE A  40
THR A  41
 None
 0.77A 5zsfA-1t9hA:
0.0
5zsfB-1t9hA:
0.0		 5zsfA-1t9hA:
12.79
5zsfB-1t9hA:
12.79