SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t9k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		4 / 4 ARG A 100
ALA A  58
ALA A 126
GLU A 128
 None
 0.93A 1e7bA-1t9kA:
undetectable		 1e7bA-1t9kA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		4 / 4 ARG A 100
ALA A  58
ALA A 126
GLU A 128
 None
 0.96A 1e7bB-1t9kA:
undetectable		 1e7bB-1t9kA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		4 / 5 ARG A 100
ALA A  58
ALA A 126
GLU A 128
 None
 0.99A 1e7cA-1t9kA:
undetectable		 1e7cA-1t9kA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		4 / 7 LEU A  17
GLN A  20
LEU A  15
PHE A  59
 None
 1.00A 2dysC-1t9kA:
undetectable
2dysJ-1t9kA:
undetectable		 2dysC-1t9kA:
19.83
2dysJ-1t9kA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		4 / 7 LEU A  17
GLN A  20
LEU A  15
PHE A  59
 None
 1.07A 2dysP-1t9kA:
undetectable
2dysW-1t9kA:
undetectable		 2dysP-1t9kA:
19.83
2dysW-1t9kA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		4 / 6 LEU A  17
GLN A  20
LEU A  15
PHE A  59
 None
 1.10A 2einP-1t9kA:
undetectable
2einW-1t9kA:
undetectable		 2einP-1t9kA:
19.83
2einW-1t9kA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EZ7_A_DHIA301_0
(CARBONIC ANHYDRASE 2)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		4 / 6 HIS A 153
ASN A 244
THR A 188
PRO A 190
 None
 1.17A 2ez7A-1t9kA:
undetectable		 2ez7A-1t9kA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		4 / 8 ILE A 322
ILE A 337
ARG A 276
ILE A 319
 None
 0.65A 2nniA-1t9kA:
1.3		 2nniA-1t9kA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		4 / 6 LEU A  17
GLN A  20
LEU A  15
PHE A  59
 None
 1.01A 3ag1C-1t9kA:
1.4
3ag1J-1t9kA:
undetectable		 3ag1C-1t9kA:
19.83
3ag1J-1t9kA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		5 / 11 ASN A 155
GLY A 165
ILE A 171
THR A 198
LEU A 202
 None
 1.27A 3bexC-1t9kA:
undetectable
3bexD-1t9kA:
undetectable		 3bexC-1t9kA:
22.16
3bexD-1t9kA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		5 / 11 THR A 198
LEU A 202
ASN A 155
GLY A 165
ILE A 171
 None
 1.27A 3bexE-1t9kA:
undetectable
3bexF-1t9kA:
undetectable		 3bexE-1t9kA:
22.16
3bexF-1t9kA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		5 / 11 ASN A 155
GLY A 165
ILE A 171
THR A 198
LEU A 202
 None
 1.27A 3bf1A-1t9kA:
undetectable
3bf1B-1t9kA:
undetectable		 3bf1A-1t9kA:
22.16
3bf1B-1t9kA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		5 / 12 THR A 198
LEU A 202
ASN A 155
GLY A 165
ILE A 171
 None
 1.26A 3bf1A-1t9kA:
undetectable
3bf1B-1t9kA:
undetectable		 3bf1A-1t9kA:
22.16
3bf1B-1t9kA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		5 / 11 ASN A 155
GLY A 165
ILE A 171
THR A 198
LEU A 202
 None
 1.29A 3bf1C-1t9kA:
undetectable
3bf1D-1t9kA:
undetectable		 3bf1C-1t9kA:
22.16
3bf1D-1t9kA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		5 / 11 THR A 198
LEU A 202
ASN A 155
GLY A 165
ILE A 171
 None
 1.29A 3bf1C-1t9kA:
undetectable
3bf1D-1t9kA:
undetectable		 3bf1C-1t9kA:
22.16
3bf1D-1t9kA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		5 / 11 THR A 198
LEU A 202
ASN A 155
GLY A 165
ILE A 171
 None
 1.27A 3bf1E-1t9kA:
undetectable
3bf1F-1t9kA:
undetectable		 3bf1E-1t9kA:
22.16
3bf1F-1t9kA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		4 / 5 VAL A 230
VAL A 231
PHE A 184
ARG A  48
 None
None
None
SO4  A 401 (-3.9A)
 1.35A 3bjwH-1t9kA:
undetectable		 3bjwH-1t9kA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		4 / 5 VAL A 230
VAL A 231
PHE A 184
ARG A  48
 None
None
None
SO4  A 401 (-3.9A)
 1.30A 3bjwB-1t9kA:
0.0		 3bjwB-1t9kA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		4 / 8 ILE A 319
HIS A 153
VAL A 231
GLY A 232
 None
 0.84A 3em0B-1t9kA:
undetectable		 3em0B-1t9kA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		3 / 3 MET A  45
CYH A 154
PRO A 190
 SO4  A 401 ( 4.1A)
SO4  A 401 (-3.6A)
None
 1.19A 3h52C-1t9kA:
undetectable		 3h52C-1t9kA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		5 / 12 SER A  11
LEU A  15
PHE A  59
VAL A  62
PHE A 115
 None
 1.38A 3nuvA-1t9kA:
undetectable		 3nuvA-1t9kA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		5 / 8 ASN A 244
GLY A 232
ALA A 233
GLY A  49
THR A  90
 None
None
None
SO4  A 401 (-3.3A)
None
 1.31A 3so9A-1t9kA:
undetectable		 3so9A-1t9kA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		4 / 4 ASN A 155
ALA A 160
GLY A 157
THR A 166
 None
 1.07A 4bboC-1t9kA:
undetectable		 4bboC-1t9kA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		3 / 3 ILE A 117
MET A 101
ARG A 100
 None
 0.93A 4lnwA-1t9kA:
0.0		 4lnwA-1t9kA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		3 / 3 ILE A 117
MET A 101
ARG A 100
 None
 0.94A 4lnxA-1t9kA:
0.0		 4lnxA-1t9kA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		5 / 12 ASN A 258
ILE A 260
GLY A 218
ALA A 217
VAL A 229
 None
 1.06A 4nkvA-1t9kA:
undetectable		 4nkvA-1t9kA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		5 / 12 ASN A 258
ILE A 260
GLY A 218
ALA A 217
VAL A 229
 None
 1.04A 4nkvD-1t9kA:
undetectable		 4nkvD-1t9kA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		4 / 5 TYR A  29
LYS A   6
LEU A  23
GLU A  27
 None
 1.50A 5js1A-1t9kA:
1.6		 5js1A-1t9kA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		3 / 3 ALA A 185
GLN A 193
THR A 198
 None
SO4  A 401 (-4.4A)
None
 0.76A 5n0oA-1t9kA:
undetectable		 5n0oA-1t9kA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		3 / 3 TRP A 219
MET A 216
ASN A 215
 None
 1.20A 5uc1B-1t9kA:
0.1		 5uc1B-1t9kA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		3 / 3 TRP A 219
MET A 216
ASN A 215
 None
 1.20A 5uc1A-1t9kA:
undetectable		 5uc1A-1t9kA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		4 / 5 THR A   7
GLU A 201
THR A 198
HIS A 153
 None
 1.33A 5utuH-1t9kA:
2.1		 5utuH-1t9kA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		5 / 12 ALA A  57
GLU A  37
LEU A  17
ILE A  46
ARG A  21
 None
 1.23A 5vlmE-1t9kA:
undetectable		 5vlmE-1t9kA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		4 / 5 LEU A 159
LYS A   6
LEU A  23
GLU A  27
 None
 1.22A 5weaA-1t9kA:
undetectable		 5weaA-1t9kA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		4 / 7 PHE A  59
GLY A  60
GLY A  64
THR A  87
 None
 0.71A 5ybbB-1t9kA:
2.4		 5ybbB-1t9kA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Thermotoga
maritima) 		4 / 6 ILE A 181
LEU A 202
VAL A 175
ARG A 172
 None
 1.21A 6f6jA-1t9kA:
undetectable		 6f6jA-1t9kA:
undetectable