SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ta9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		4 / 6 THR A  91
LEU A 114
GLY A 118
TYR A  83
 None
 1.32A 1gtiC-1ta9A:
0.0		 1gtiC-1ta9A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		4 / 5 SER A 235
PHE A 306
GLU A 239
GLY A 310
 K  A1503 (-2.9A)
GOL  A1401 ( 3.8A)
None
None
 1.34A 1icrA-1ta9A:
undetectable
1icrB-1ta9A:
undetectable		 1icrA-1ta9A:
17.00
1icrB-1ta9A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_A_NIOA704_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		4 / 4 SER A 235
PHE A 306
GLU A 239
GLY A 310
 K  A1503 (-2.9A)
GOL  A1401 ( 3.8A)
None
None
 1.36A 1icvA-1ta9A:
0.0
1icvB-1ta9A:
0.0		 1icvA-1ta9A:
17.00
1icvB-1ta9A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		4 / 5 GLU A 239
GLY A 310
SER A 235
PHE A 306
 None
None
K  A1503 (-2.9A)
GOL  A1401 ( 3.8A)
 1.30A 1kqbA-1ta9A:
undetectable
1kqbB-1ta9A:
undetectable		 1kqbA-1ta9A:
19.38
1kqbB-1ta9A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 367
GLU A 239
CYH A 267
ALA A 233
ALA A 297
 None
 1.05A 2bm9D-1ta9A:
3.6		 2bm9D-1ta9A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 367
CYH A 267
ASP A 232
ALA A 233
ALA A 297
 None
None
ZN  A1502 (-2.1A)
None
None
 1.05A 2br4A-1ta9A:
3.8		 2br4A-1ta9A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 367
CYH A 267
ASP A 232
ALA A 233
ALA A 297
 None
None
ZN  A1502 (-2.1A)
None
None
 1.14A 2br4C-1ta9A:
3.7		 2br4C-1ta9A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		4 / 7 SER A 235
THR A 240
GLY A 303
ASP A 182
 K  A1503 (-2.9A)
None
None
GOL  A1401 ( 2.6A)
 0.96A 2ddwB-1ta9A:
undetectable		 2ddwB-1ta9A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 285
THR A 288
ALA A 221
THR A 178
ALA A 179
 None
 1.05A 2gluA-1ta9A:
undetectable		 2gluA-1ta9A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 285
THR A 288
ALA A 221
THR A 178
ALA A 179
 None
 1.03A 2gluB-1ta9A:
undetectable		 2gluB-1ta9A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		4 / 5 HIS A 318
HIS A 315
VAL A 337
HIS A 333
 None
ZN  A1502 (-3.4A)
None
ZN  A1502 ( 3.4A)
 1.01A 2wkoF-1ta9A:
undetectable		 2wkoF-1ta9A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 12 ALA A 233
GLY A 229
LEU A 234
GLY A 303
SER A 302
 None
None
None
None
K  A1503 (-3.6A)
 0.93A 3g2oA-1ta9A:
undetectable		 3g2oA-1ta9A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 12 ALA A 233
LEU A 234
SER A 228
GLY A 303
SER A 302
 None
None
None
None
K  A1503 (-3.6A)
 1.01A 3g2oA-1ta9A:
undetectable		 3g2oA-1ta9A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 12 ALA A 233
GLY A 229
LEU A 234
GLY A 303
SER A 302
 None
None
None
None
K  A1503 (-3.6A)
 0.93A 3g2oB-1ta9A:
undetectable		 3g2oB-1ta9A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A 347
ILE A 414
ALA A 411
THR A 391
 None
 0.97A 3mdrA-1ta9A:
undetectable		 3mdrA-1ta9A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 12 SER A 257
PHE A  66
THR A  67
ALA A 252
GLY A 309
 None
 1.08A 3tegA-1ta9A:
undetectable		 3tegA-1ta9A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A 265
ARG A 261
TRP A 237
 None
 1.46A 4cpzC-1ta9A:
undetectable		 4cpzC-1ta9A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A 265
ARG A 261
TRP A 237
 None
 1.49A 4cpzH-1ta9A:
undetectable		 4cpzH-1ta9A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 11 ILE A 414
ILE A 410
ALA A 313
ALA A 314
VAL A 387
 None
 1.21A 4h1nA-1ta9A:
undetectable		 4h1nA-1ta9A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		3 / 3 HIS A 366
VAL A 294
LEU A 226
 None
 0.70A 4m2vA-1ta9A:
undetectable		 4m2vA-1ta9A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A  79
ILE A 173
ILE A 174
ALA A  98
THR A 157
 None
 0.96A 4nkvC-1ta9A:
undetectable		 4nkvC-1ta9A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A  79
ILE A 173
ILE A 174
ALA A  98
THR A 157
 None
 0.98A 4nkvD-1ta9A:
0.0		 4nkvD-1ta9A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 12 HIS A 333
GLY A 334
TYR A 201
VAL A 243
GLY A 340
 ZN  A1502 ( 3.4A)
None
None
None
None
 1.21A 5hg0A-1ta9A:
undetectable		 5hg0A-1ta9A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		4 / 5 CYH A 365
ILE A 448
LEU A 367
HIS A 444
 None
 1.43A 5hrqC-1ta9A:
undetectable
5hrqD-1ta9A:
undetectable
5hrqL-1ta9A:
undetectable		 5hrqC-1ta9A:
4.21
5hrqD-1ta9A:
5.41
5hrqL-1ta9A:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1ta9 GLYCEROL
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		4 / 7 SER A 180
THR A 178
PRO A 176
ILE A 174
 None
 1.24A 5vkqA-1ta9A:
undetectable
5vkqB-1ta9A:
undetectable		 5vkqA-1ta9A:
13.56
5vkqB-1ta9A:
13.56