SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tah'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 1tah LIPASE
(Burkholderia
glumae) 		5 / 12 ALA B 246
LEU B 245
LEU B 265
ILE B 289
LEU B 292
 None
 1.22A 1errA-1tahB:
undetectable		 1errA-1tahB:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 1tah LIPASE
(Burkholderia
glumae) 		4 / 4 LEU B 206
THR B 196
ILE B  84
HIS B 310
 None
 1.42A 2jfaB-1tahB:
0.0		 2jfaB-1tahB:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 1tah LIPASE
(Burkholderia
glumae) 		5 / 12 THR B 112
VAL B  14
ALA B  47
VAL B  72
VAL B  44
 None
 1.28A 2nniA-1tahB:
0.0		 2nniA-1tahB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1tah LIPASE
(Burkholderia
glumae) 		5 / 12 VAL B  14
LEU B 167
ASP B  55
LEU B  91
TYR B  29
 None
 1.20A 2oipC-1tahB:
undetectable		 2oipC-1tahB:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 1tah LIPASE
(Burkholderia
glumae) 		4 / 6 LEU B  65
VAL B  69
LYS B  70
ILE B  12
 None
 0.50A 2piwA-1tahB:
undetectable		 2piwA-1tahB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1tah LIPASE
(Burkholderia
glumae) 		4 / 8 THR B 108
TYR B 207
ILE B 277
SER B 106
 None
 1.11A 2xytH-1tahB:
undetectable		 2xytH-1tahB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1tah LIPASE
(Burkholderia
glumae) 		4 / 7 THR B 108
TYR B 207
ILE B 277
SER B 106
 None
 1.12A 2xytI-1tahB:
undetectable		 2xytI-1tahB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1tah LIPASE
(Burkholderia
glumae) 		5 / 8 ASP B 235
GLY B 297
ALA B 237
ASP B 241
LEU B 248
 None
None
None
CA  B 320 ( 3.1A)
None
 1.49A 3em6A-1tahB:
undetectable		 3em6A-1tahB:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1tah LIPASE
(Burkholderia
glumae) 		4 / 5 SER B 189
ARG B 115
GLY B 183
GLU B 197
 None
 1.11A 3k9fA-1tahB:
undetectable
3k9fB-1tahB:
undetectable
3k9fC-1tahB:
2.9		 3k9fA-1tahB:
22.90
3k9fB-1tahB:
22.90
3k9fC-1tahB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1tah LIPASE
(Burkholderia
glumae) 		4 / 6 ARG B 115
SER B 189
GLY B 183
GLU B 197
 None
 1.11A 3k9fA-1tahB:
undetectable
3k9fB-1tahB:
undetectable
3k9fD-1tahB:
2.8		 3k9fA-1tahB:
22.90
3k9fB-1tahB:
22.90
3k9fD-1tahB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1tah LIPASE
(Burkholderia
glumae) 		3 / 3 GLY B 210
ILE B 307
VAL B 306
 None
 0.46A 3nv6A-1tahB:
undetectable		 3nv6A-1tahB:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1tah LIPASE
(Burkholderia
glumae) 		3 / 3 ARG B  94
VAL B 276
THR B 192
 None
 0.80A 3pwrA-1tahB:
undetectable		 3pwrA-1tahB:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 1tah LIPASE
(Burkholderia
glumae) 		4 / 5 HIS B 285
ILE B 289
HIS B  86
LEU B  17
 None
 1.24A 3qpkA-1tahB:
undetectable		 3qpkA-1tahB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1tah LIPASE
(Burkholderia
glumae) 		5 / 8 GLY B  16
GLY B  89
SER B  87
GLY B 111
VAL B 266
 None
 1.42A 3v1nA-1tahB:
12.6		 3v1nA-1tahB:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 1tah LIPASE
(Burkholderia
glumae) 		5 / 12 PHE B 179
PRO B 180
ARG B  94
GLY B 116
LEU B 167
 None
 1.31A 4oadA-1tahB:
0.7		 4oadA-1tahB:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 1tah LIPASE
(Burkholderia
glumae) 		4 / 7 PRO B 216
SER B 267
GLU B 118
THR B 172
 None
 1.14A 4uacA-1tahB:
undetectable		 4uacA-1tahB:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 1tah LIPASE
(Burkholderia
glumae) 		5 / 10 GLY B 232
ALA B 300
ASP B 287
SER B 230
ALA B 213
 None
None
CA  B 320 ( 3.4A)
None
None
 1.20A 4wnuD-1tahB:
undetectable		 4wnuD-1tahB:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1tah LIPASE
(Burkholderia
glumae) 		4 / 6 HIS B 285
MET B 254
LEU B 167
LEU B 164
 None
 1.30A 5dzke-1tahB:
2.6
5dzks-1tahB:
undetectable		 5dzke-1tahB:
21.78
5dzks-1tahB:
0.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1tah LIPASE
(Burkholderia
glumae) 		5 / 12 ILE B 214
ALA B 141
VAL B 138
GLY B 147
THR B 148
 None
 1.17A 5igiA-1tahB:
undetectable		 5igiA-1tahB:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1tah LIPASE
(Burkholderia
glumae) 		5 / 9 THR B 212
GLY B 211
ALA B 213
GLY B 210
SER B 278
 None
 1.27A 5vw4A-1tahB:
undetectable		 5vw4A-1tahB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1tah LIPASE
(Burkholderia
glumae) 		5 / 9 THR B 250
GLY B 251
ALA B 252
GLY B 264
LEU B 265
 None
 1.31A 5vw4A-1tahB:
undetectable		 5vw4A-1tahB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1tah LIPASE
(Burkholderia
glumae) 		5 / 9 THR B 250
GLY B 251
ALA B 252
LEU B 265
SER B 117
 None
 1.21A 5vw4A-1tahB:
undetectable		 5vw4A-1tahB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1tah LIPASE
(Burkholderia
glumae) 		5 / 8 THR B 212
GLY B 211
ALA B 213
GLY B 210
SER B 278
 None
 1.23A 5vw9A-1tahB:
undetectable		 5vw9A-1tahB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 1tah LIPASE
(Burkholderia
glumae) 		5 / 12 LEU B  65
GLY B  62
ALA B  47
GLY B  89
ALA B  18
 None
 0.97A 5xv7A-1tahB:
undetectable		 5xv7A-1tahB:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 1tah LIPASE
(Burkholderia
glumae) 		4 / 4 VAL B 150
GLY B  19
ASP B 159
ASP B  21
 None
 1.49A 6cjkC-1tahB:
undetectable		 6cjkC-1tahB:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 1tah LIPASE
(Burkholderia
glumae) 		5 / 12 LEU B 286
LEU B  17
GLY B  16
ILE B 110
ILE B  33
 None
 1.02A 6ecxA-1tahB:
undetectable		 6ecxA-1tahB:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1tah LIPASE
(Burkholderia
glumae) 		4 / 4 ARG B 165
GLN B 124
PHE B 122
LEU B 161
 None
 1.18A 6nmfC-1tahB:
0.0		 6nmfC-1tahB:
22.54