SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tc1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEE_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 1tc1 PROTEIN
(HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE)
(Trypanosoma
cruzi) 		5 / 12 LEU A  61
VAL A 157
TYR A 155
PHE A  68
LEU A  65
 None
 1.27A 3meeA-1tc1A:
0.0		 3meeA-1tc1A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEG_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 1tc1 PROTEIN
(HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE)
(Trypanosoma
cruzi) 		5 / 12 LEU A  61
VAL A 157
TYR A 155
PHE A  68
LEU A  65
 None
 1.30A 3megA-1tc1A:
0.0		 3megA-1tc1A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1tc1 PROTEIN
(HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE)
(Trypanosoma
cruzi) 		5 / 12 TYR A   5
GLU A  15
GLY A 169
ASP A 112
LEU A 140
 None
None
None
MES  A 800 ( 4.0A)
None
 1.37A 3ou6D-1tc1A:
2.2		 3ou6D-1tc1A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1tc1 PROTEIN
(HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE)
(Trypanosoma
cruzi) 		5 / 9 ILE A 102
THR A 137
LEU A 135
LEU A 123
LEU A 120
 None
None
None
None
MES  A 800 (-3.8A)
 1.28A 5fhzB-1tc1A:
undetectable		 5fhzB-1tc1A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 1tc1 PROTEIN
(HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE)
(Trypanosoma
cruzi) 		5 / 12 LEU A 140
VAL A  25
ILE A  29
ALA A  30
VAL A 138
 None
 0.79A 5j2tC-1tc1A:
3.4		 5j2tC-1tc1A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1tc1 PROTEIN
(HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE)
(Trypanosoma
cruzi) 		3 / 3 ALA A  30
VAL A 138
TYR A 155
 None
 0.70A 5zmqH-1tc1A:
undetectable		 5zmqH-1tc1A:
20.80