SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tc5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1tc5 PROBABLE EUKARYOTIC
D-AMINO ACID TRNA
DEACYLASE,
LMAJ005534AAA
(Leishmania
major) 		4 / 8 LEU A  86
PHE A  74
LEU A  15
ALA A  17
 None
 0.96A 1fiqC-1tc5A:
undetectable		 1fiqC-1tc5A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 1tc5 PROBABLE EUKARYOTIC
D-AMINO ACID TRNA
DEACYLASE,
LMAJ005534AAA
(Leishmania
major) 		5 / 9 LEU A  66
VAL A  62
ILE A 194
VAL A  13
ILE A  42
 None
 1.43A 1gebA-1tc5A:
undetectable		 1gebA-1tc5A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1tc5 PROBABLE EUKARYOTIC
D-AMINO ACID TRNA
DEACYLASE,
LMAJ005534AAA
(Leishmania
major) 		4 / 6 VAL A 169
SER A 171
ARG A 134
HIS A 131
 None
 1.33A 2f8dA-1tc5A:
undetectable		 2f8dA-1tc5A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1tc5 PROBABLE EUKARYOTIC
D-AMINO ACID TRNA
DEACYLASE,
LMAJ005534AAA
(Leishmania
major) 		5 / 8 ALA A 136
LEU A  66
LEU A  65
VAL A  40
ILE A  42
 None
 1.25A 2uxpA-1tc5A:
undetectable		 2uxpA-1tc5A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1tc5 PROBABLE EUKARYOTIC
D-AMINO ACID TRNA
DEACYLASE,
LMAJ005534AAA
(Leishmania
major) 		5 / 12 ILE A 194
ALA A 136
VAL A  64
LEU A  66
LEU A  86
 None
 0.92A 2yqzA-1tc5A:
undetectable		 2yqzA-1tc5A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1tc5 PROBABLE EUKARYOTIC
D-AMINO ACID TRNA
DEACYLASE,
LMAJ005534AAA
(Leishmania
major) 		5 / 12 ILE A 194
ALA A 136
VAL A  64
LEU A  66
LEU A  86
 None
 0.93A 2yqzB-1tc5A:
undetectable		 2yqzB-1tc5A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 1tc5 PROBABLE EUKARYOTIC
D-AMINO ACID TRNA
DEACYLASE,
LMAJ005534AAA
(Leishmania
major) 		3 / 3 HIS A  22
ARG A 181
GLU A 183
 None
 0.89A 3qf1A-1tc5A:
undetectable		 3qf1A-1tc5A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 1tc5 PROBABLE EUKARYOTIC
D-AMINO ACID TRNA
DEACYLASE,
LMAJ005534AAA
(Leishmania
major) 		4 / 7 PHE A  71
PHE A  74
LEU A  65
LEU A  86
 None
 0.83A 4ejgC-1tc5A:
undetectable		 4ejgC-1tc5A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 1tc5 PROBABLE EUKARYOTIC
D-AMINO ACID TRNA
DEACYLASE,
LMAJ005534AAA
(Leishmania
major) 		5 / 12 GLY A  35
ASP A  93
GLN A  20
PHE A 182
HIS A  22
 None
 1.32A 4wh5A-1tc5A:
undetectable		 4wh5A-1tc5A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 1tc5 PROBABLE EUKARYOTIC
D-AMINO ACID TRNA
DEACYLASE,
LMAJ005534AAA
(Leishmania
major) 		5 / 8 LEU A  86
VAL A 133
ARG A 137
LEU A  15
ILE A  96
 None
 1.45A 5v0vA-1tc5A:
undetectable		 5v0vA-1tc5A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 1tc5 PROBABLE EUKARYOTIC
D-AMINO ACID TRNA
DEACYLASE,
LMAJ005534AAA
(Leishmania
major) 		5 / 12 GLY A 103
LEU A  65
ARG A  12
ILE A  11
ASP A 193
 None
 1.11A 6bxmA-1tc5A:
undetectable		 6bxmA-1tc5A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1tc5 PROBABLE EUKARYOTIC
D-AMINO ACID TRNA
DEACYLASE,
LMAJ005534AAA
(Leishmania
major) 		5 / 11 VAL A  64
VAL A  38
LEU A  15
PHE A 129
VAL A 133
 None
 1.35A 6dryA-1tc5A:
undetectable		 6dryA-1tc5A:
16.14