SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tcd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1tcd TRIOSEPHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 12 ILE A  49
ALA A  64
LEU A  56
SER A 238
LEU A  22
 None
 1.20A 1ddsB-1tcdA:
undetectable		 1ddsB-1tcdA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 1tcd TRIOSEPHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		3 / 3 ALA A  65
VAL A  42
TRP A  13
 None
 0.86A 1kqeA-1tcdA:
undetectable
1kqeE-1tcdA:
undetectable		 1kqeA-1tcdA:
7.27
1kqeE-1tcdA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 1tcd TRIOSEPHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		3 / 3 ALA A  65
VAL A  42
TRP A  13
 None
 0.85A 1kqeB-1tcdA:
undetectable
1kqeD-1tcdA:
undetectable		 1kqeB-1tcdA:
7.27
1kqeD-1tcdA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 1tcd TRIOSEPHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		3 / 3 TRP A  13
ALA A  65
VAL A  42
 None
 0.85A 1kqeB-1tcdA:
undetectable
1kqeD-1tcdA:
undetectable		 1kqeB-1tcdA:
7.27
1kqeD-1tcdA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 1tcd TRIOSEPHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		3 / 3 TRP A  13
ALA A  65
VAL A  42
 None
 0.84A 1kqeA-1tcdA:
undetectable
1kqeE-1tcdA:
undetectable		 1kqeA-1tcdA:
7.27
1kqeE-1tcdA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 1tcd TRIOSEPHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 10 GLY A 212
VAL A 215
ALA A 184
ASN A 219
ILE A 229
 None
 1.02A 1likA-1tcdA:
undetectable		 1likA-1tcdA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1tcd TRIOSEPHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		4 / 5 ILE A 209
LEU A 207
VAL A 163
CYH A 118
 None
 0.98A 1mz9C-1tcdA:
undetectable		 1mz9C-1tcdA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1tcd TRIOSEPHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 12 VAL A 114
CYH A 118
ALA A 120
LEU A  81
VAL A 126
 None
 0.99A 3fc6C-1tcdA:
undetectable		 3fc6C-1tcdA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 1tcd TRIOSEPHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		4 / 7 ILE A 229
LEU A 223
HIS A 188
SER A  97
 None
 0.82A 3r9vA-1tcdA:
undetectable
3r9vB-1tcdA:
undetectable		 3r9vA-1tcdA:
22.86
3r9vB-1tcdA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1tcd TRIOSEPHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		4 / 8 ALA A 184
VAL A 187
LEU A 191
LEU A 210
 None
 0.67A 3roxA-1tcdA:
undetectable		 3roxA-1tcdA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 1tcd TRIOSEPHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		4 / 5 VAL A 195
LEU A 199
ILE A 203
VAL A 163
 None
 0.95A 4a9kB-1tcdA:
undetectable		 4a9kB-1tcdA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 1tcd TRIOSEPHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 9 THR A  52
LEU A  21
LEU A  22
GLY A  17
THR A  45
 None
 1.47A 4c9kB-1tcdA:
0.0		 4c9kB-1tcdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 1tcd TRIOSEPHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 8 THR A  52
LEU A  21
LEU A  22
GLY A  17
THR A  45
 None
 1.48A 4c9nA-1tcdA:
undetectable		 4c9nA-1tcdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 1tcd TRIOSEPHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		3 / 3 LEU A  56
LYS A  53
THR A  52
 None
 0.56A 4lj0A-1tcdA:
undetectable		 4lj0A-1tcdA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1tcd TRIOSEPHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		3 / 3 LEU A  94
LEU A 210
ASN A  12
 None
 0.64A 4otwA-1tcdA:
undetectable		 4otwA-1tcdA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1tcd TRIOSEPHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 8 THR A  28
ILE A 246
GLU A 242
LEU A 239
PHE A 243
 None
 1.41A 4r38B-1tcdA:
undetectable		 4r38B-1tcdA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 1tcd TRIOSEPHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 233
THR A  45
ALA A  43
VAL A  41
ALA A  10
 None
 1.19A 4x1iB-1tcdA:
undetectable		 4x1iB-1tcdA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 1tcd TRIOSEPHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 233
THR A  45
ALA A  43
VAL A  41
ALA A  10
 None
 1.15A 4x1kD-1tcdA:
undetectable		 4x1kD-1tcdA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 1tcd TRIOSEPHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 11 VAL A 215
SER A 214
THR A 175
TYR A 211
LEU A 223
 None
 1.41A 5jh7B-1tcdA:
undetectable		 5jh7B-1tcdA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 1tcd TRIOSEPHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 11 GLN A 183
VAL A 215
SER A 214
THR A 175
TYR A 211
 None
 1.47A 5jh7D-1tcdA:
undetectable		 5jh7D-1tcdA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 1tcd TRIOSEPHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 11 VAL A 215
SER A 214
THR A 175
TYR A 211
LEU A 223
 None
 1.39A 5jh7D-1tcdA:
undetectable		 5jh7D-1tcdA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 1tcd TRIOSEPHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		3 / 3 ARG A 192
ARG A 227
ASP A 228
 None
 0.70A 6d8pA-1tcdA:
undetectable		 6d8pA-1tcdA:
18.18