SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tdf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		5 / 9 VAL A  49
LEU A  59
ILE A 296
ALA A 295
LEU A  43
 FAD  A 500 (-3.4A)
None
None
FAD  A 500 (-3.6A)
FAD  A 500 (-3.3A)
 1.14A 1eqgA-1tdfA:
undetectable		 1eqgA-1tdfA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		5 / 11 VAL A  49
LEU A  59
ILE A 296
ALA A 295
LEU A  43
 FAD  A 500 (-3.4A)
None
None
FAD  A 500 (-3.6A)
FAD  A 500 (-3.3A)
 1.13A 1eqgB-1tdfA:
undetectable		 1eqgB-1tdfA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		3 / 3 ILE A 187
LEU A 190
VAL A 194
 None
 0.28A 1mz9B-1tdfA:
undetectable		 1mz9B-1tdfA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		3 / 3 LEU A 119
LEU A 121
SER A 123
 NAP  A 481 (-3.9A)
None
None
 0.57A 1tlmA-1tdfA:
undetectable		 1tlmA-1tdfA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		5 / 8 GLY A 152
GLY A 153
GLY A 154
ALA A 157
ILE A 187
 NAP  A 481 ( 3.9A)
NAP  A 481 (-4.4A)
NAP  A 481 ( 3.9A)
None
None
 1.02A 1yajC-1tdfA:
undetectable		 1yajC-1tdfA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		3 / 3 ARG A  92
THR A 276
VAL A 281
 None
 1.00A 2qakA-1tdfA:
undetectable		 2qakA-1tdfA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		5 / 9 THR A 156
GLY A 154
GLY A 244
ARG A 176
ILE A 243
 NAP  A 481 (-3.5A)
NAP  A 481 ( 3.9A)
NAP  A 481 (-3.4A)
NAP  A 481 (-3.6A)
NAP  A 481 (-3.8A)
 1.45A 2y7wA-1tdfA:
undetectable		 2y7wA-1tdfA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		5 / 12 ILE A 110
ILE A 109
GLY A 285
ALA A 283
ALA A 295
 None
None
FAD  A 500 (-3.1A)
None
FAD  A 500 (-3.6A)
 0.95A 2yvlA-1tdfA:
3.4		 2yvlA-1tdfA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		5 / 12 ILE A 110
ILE A 109
GLY A 285
ALA A 283
ALA A 295
 None
None
FAD  A 500 (-3.1A)
None
FAD  A 500 (-3.6A)
 0.96A 2yvlC-1tdfA:
4.7		 2yvlC-1tdfA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		5 / 12 ILE A 110
ALA A 284
ALA A  16
VAL A  87
ILE A 251
 None
None
FAD  A 500 (-3.4A)
None
FAD  A 500 ( 4.3A)
 1.03A 3e00A-1tdfA:
undetectable		 3e00A-1tdfA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		5 / 12 GLY A 285
ASP A 289
ALA A 299
GLY A 300
ILE A 109
 FAD  A 500 (-3.1A)
None
None
None
None
 0.90A 3ku1C-1tdfA:
5.4		 3ku1C-1tdfA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		4 / 5 ARG A 117
LEU A 121
ARG A 176
ILE A 174
 NAP  A 481 ( 4.8A)
None
NAP  A 481 (-3.6A)
None
 1.23A 3ln1D-1tdfA:
0.0		 3ln1D-1tdfA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		4 / 6 VAL A 194
MET A 191
VAL A 171
PHE A 180
 None
 1.13A 3soaA-1tdfA:
undetectable		 3soaA-1tdfA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		4 / 7 PRO A  53
LEU A  64
LEU A  43
ILE A 296
 None
None
FAD  A 500 (-3.3A)
None
 1.03A 3u5jA-1tdfA:
undetectable		 3u5jA-1tdfA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		5 / 8 PRO A  53
VAL A  49
LEU A  64
LEU A  43
ILE A 296
 None
FAD  A 500 (-3.4A)
None
FAD  A 500 (-3.3A)
None
 0.98A 3u5kA-1tdfA:
undetectable		 3u5kA-1tdfA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		4 / 7 PRO A  53
VAL A  49
LEU A  64
LEU A  43
 None
FAD  A 500 (-3.4A)
None
FAD  A 500 (-3.3A)
 0.91A 3u5kB-1tdfA:
undetectable		 3u5kB-1tdfA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		5 / 8 PRO A  53
VAL A  49
LEU A  64
LEU A  43
ILE A 296
 None
FAD  A 500 (-3.4A)
None
FAD  A 500 (-3.3A)
None
 0.99A 3u5kC-1tdfA:
undetectable		 3u5kC-1tdfA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		5 / 8 PRO A  53
VAL A  49
LEU A  64
LEU A  43
ILE A 296
 None
FAD  A 500 (-3.4A)
None
FAD  A 500 (-3.3A)
None
 1.09A 3u5kD-1tdfA:
undetectable		 3u5kD-1tdfA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		5 / 11 GLY A 285
GLY A 113
ILE A 110
ASP A 286
PRO A  15
 FAD  A 500 (-3.1A)
FAD  A 500 (-3.5A)
None
FAD  A 500 (-2.0A)
FAD  A 500 (-3.6A)
 1.10A 4dcmA-1tdfA:
2.7		 4dcmA-1tdfA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		5 / 12 LEU A 222
LEU A 207
ILE A 174
GLY A 219
LEU A 234
 None
 0.92A 4lmnA-1tdfA:
undetectable		 4lmnA-1tdfA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		4 / 6 ASN A 100
ILE A  34
ILE A  80
VAL A  32
 None
 0.90A 4olmA-1tdfA:
undetectable		 4olmA-1tdfA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA302_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		4 / 5 PRO A  15
MET A  65
LEU A  59
TRP A  52
 FAD  A 500 (-3.6A)
None
None
None
 1.31A 4ww7A-1tdfA:
0.0		 4ww7A-1tdfA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		4 / 8 ALA A 284
GLY A 302
ALA A  20
GLY A  17
 None
 0.63A 4zjzA-1tdfA:
undetectable		 4zjzA-1tdfA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		5 / 12 THR A 301
ALA A 305
SER A  13
GLY A  14
ALA A 111
 None
None
FAD  A 500 (-2.9A)
FAD  A 500 (-3.3A)
FAD  A 500 (-4.9A)
 1.20A 5lf7V-1tdfA:
undetectable
5lf7b-1tdfA:
undetectable		 5lf7V-1tdfA:
20.85
5lf7b-1tdfA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		5 / 12 THR A 301
ALA A 305
SER A  13
GLY A  14
ALA A 111
 None
None
FAD  A 500 (-2.9A)
FAD  A 500 (-3.3A)
FAD  A 500 (-4.9A)
 1.19A 5lf7H-1tdfA:
undetectable
5lf7N-1tdfA:
undetectable		 5lf7H-1tdfA:
20.85
5lf7N-1tdfA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1tdf THIOREDOXIN
REDUCTASE
(Escherichia
coli) 		5 / 8 GLY A  12
LEU A  11
VAL A 281
VAL A 287
LEU A 108
 FAD  A 500 (-3.3A)
FAD  A 500 ( 4.7A)
None
None
None
 1.42A 6czmD-1tdfA:
undetectable
6czmF-1tdfA:
undetectable		 6czmD-1tdfA:
22.85
6czmF-1tdfA:
22.85