SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tdh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1tdh NEI ENDONUCLEASE
VIII-LIKE 1
(Homo
sapiens) 		4 / 8 ILE A  47
LEU A 112
PHE A 101
LEU A  56
 None
 0.92A 1v55N-1tdhA:
undetectable
1v55W-1tdhA:
undetectable		 1v55N-1tdhA:
20.00
1v55W-1tdhA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1tdh NEI ENDONUCLEASE
VIII-LIKE 1
(Homo
sapiens) 		5 / 12 PHE A 101
LEU A  60
ALA A  20
CYH A  18
VAL A  14
 None
 1.35A 2g70A-1tdhA:
undetectable		 2g70A-1tdhA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1tdh NEI ENDONUCLEASE
VIII-LIKE 1
(Homo
sapiens) 		5 / 12 PHE A 101
LEU A  60
ALA A  20
CYH A  18
VAL A  14
 None
 1.34A 2g72A-1tdhA:
undetectable		 2g72A-1tdhA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1tdh NEI ENDONUCLEASE
VIII-LIKE 1
(Homo
sapiens) 		5 / 12 PHE A  23
ALA A  10
SER A  11
ALA A  49
GLY A 245
 None
 1.09A 2igtA-1tdhA:
undetectable		 2igtA-1tdhA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1tdh NEI ENDONUCLEASE
VIII-LIKE 1
(Homo
sapiens) 		5 / 12 PHE A  23
ALA A  10
SER A  11
ALA A  49
GLY A 245
 None
 1.08A 2igtB-1tdhA:
undetectable		 2igtB-1tdhA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1tdh NEI ENDONUCLEASE
VIII-LIKE 1
(Homo
sapiens) 		4 / 8 ILE A  47
LEU A 112
PHE A 101
LEU A  56
 None
 0.92A 3abmN-1tdhA:
undetectable
3abmW-1tdhA:
undetectable		 3abmN-1tdhA:
20.00
3abmW-1tdhA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1tdh NEI ENDONUCLEASE
VIII-LIKE 1
(Homo
sapiens) 		4 / 8 ILE A  47
LEU A 112
PHE A 101
LEU A  56
 None
 0.94A 3asnN-1tdhA:
undetectable
3asnW-1tdhA:
0.0		 3asnN-1tdhA:
20.00
3asnW-1tdhA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1tdh NEI ENDONUCLEASE
VIII-LIKE 1
(Homo
sapiens) 		4 / 8 ILE A  47
LEU A 112
PHE A 101
LEU A  56
 None
 0.92A 3asoN-1tdhA:
undetectable
3asoW-1tdhA:
undetectable		 3asoN-1tdhA:
20.00
3asoW-1tdhA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1tdh NEI ENDONUCLEASE
VIII-LIKE 1
(Homo
sapiens) 		4 / 6 VAL A 148
LEU A 288
ILE A 279
LEU A 198
 None
 0.92A 3kk6A-1tdhA:
undetectable		 3kk6A-1tdhA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1tdh NEI ENDONUCLEASE
VIII-LIKE 1
(Homo
sapiens) 		5 / 6 VAL A 148
LEU A 288
ILE A 279
ALA A 194
LEU A 198
 None
 1.07A 3kk6B-1tdhA:
undetectable		 3kk6B-1tdhA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 1tdh NEI ENDONUCLEASE
VIII-LIKE 1
(Homo
sapiens) 		3 / 3 GLU A 163
LEU A 166
ASP A 167
 None
 0.42A 3ko0A-1tdhA:
1.4		 3ko0A-1tdhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 1tdh NEI ENDONUCLEASE
VIII-LIKE 1
(Homo
sapiens) 		3 / 3 GLU A 163
LEU A 166
ASP A 167
 None
 0.39A 3ko0T-1tdhA:
undetectable		 3ko0T-1tdhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 1tdh NEI ENDONUCLEASE
VIII-LIKE 1
(Homo
sapiens) 		4 / 5 LEU A 166
ILE A 161
PRO A 160
PHE A 191
 None
 1.12A 3s3vA-1tdhA:
undetectable		 3s3vA-1tdhA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1tdh NEI ENDONUCLEASE
VIII-LIKE 1
(Homo
sapiens) 		4 / 8 ASP A 116
GLY A  83
PHE A  79
VAL A  14
 None
 0.90A 4acbB-1tdhA:
undetectable
4acbC-1tdhA:
undetectable		 4acbB-1tdhA:
21.17
4acbC-1tdhA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1tdh NEI ENDONUCLEASE
VIII-LIKE 1
(Homo
sapiens) 		3 / 3 LEU A 165
ALA A 164
LEU A 183
 None
 0.54A 5uunB-1tdhA:
undetectable		 5uunB-1tdhA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1tdh NEI ENDONUCLEASE
VIII-LIKE 1
(Homo
sapiens) 		4 / 8 ILE A  47
LEU A 112
PHE A 101
LEU A  56
 None
 0.95A 5zcqN-1tdhA:
undetectable
5zcqW-1tdhA:
undetectable		 5zcqN-1tdhA:
20.00
5zcqW-1tdhA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 1tdh NEI ENDONUCLEASE
VIII-LIKE 1
(Homo
sapiens) 		4 / 5 ARG A 179
ALA A 180
TYR A 263
GLN A 272
 None
 1.23A 6g9bA-1tdhA:
undetectable
6g9bB-1tdhA:
undetectable		 6g9bA-1tdhA:
11.75
6g9bB-1tdhA:
12.42