SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tdj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		4 / 7 GLN A  30
ARG A 100
PHE A  96
PHE A 124
 None
 1.21A 1e71M-1tdjA:
undetectable		 1e71M-1tdjA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		4 / 7 GLN A  30
ARG A 100
PHE A  96
PHE A 124
 None
 1.21A 1e72M-1tdjA:
3.0		 1e72M-1tdjA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		4 / 4 GLY A 167
LEU A 169
GLY A 165
ARG A  64
 None
 1.45A 1j7kA-1tdjA:
undetectable		 1j7kA-1tdjA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 10 LEU A 254
ALA A 194
GLY A 188
GLY A 189
PRO A 229
 None
None
PLP  A 962 (-3.7A)
PLP  A 962 (-3.2A)
None
 0.97A 1k6cA-1tdjA:
undetectable		 1k6cA-1tdjA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		4 / 4 ILE A 395
LEU A 399
VAL A 343
ALA A 377
 None
 0.89A 1mz9A-1tdjA:
undetectable		 1mz9A-1tdjA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		4 / 5 ILE A 395
LEU A 399
VAL A 343
ALA A 377
 None
 0.94A 1mz9C-1tdjA:
undetectable		 1mz9C-1tdjA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		3 / 3 TRP A 153
VAL A 154
PRO A 155
 None
 0.81A 1rg1A-1tdjA:
undetectable		 1rg1A-1tdjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		3 / 3 TRP A 153
VAL A 154
PRO A 155
 None
 0.82A 1rh0A-1tdjA:
undetectable		 1rh0A-1tdjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 GLY A 295
ALA A 294
ILE A 313
ALA A 239
ILE A 270
 None
 0.82A 1rl8A-1tdjA:
undetectable		 1rl8A-1tdjA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 GLY A 295
ALA A 294
ILE A 313
ALA A 239
ILE A 270
 None
 0.84A 1rl8B-1tdjA:
undetectable		 1rl8B-1tdjA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 8 ALA A 211
GLY A 191
GLY A 190
ILE A 247
ALA A 214
 None
PLP  A 962 (-3.1A)
PLP  A 962 (-3.5A)
None
None
 1.05A 1sguA-1tdjA:
undetectable		 1sguA-1tdjA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 TYR A  16
ALA A 197
LEU A 192
GLN A 256
PHE A 252
 None
None
PLP  A 962 (-4.5A)
None
None
 1.27A 1udtA-1tdjA:
undetectable		 1udtA-1tdjA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 10 TYR A  16
ALA A 197
LEU A 192
GLN A 256
PHE A 252
 None
None
PLP  A 962 (-4.5A)
None
None
 1.27A 1uhoA-1tdjA:
undetectable		 1uhoA-1tdjA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		6 / 12 ILE A 270
ALA A 294
ALA A 273
LEU A 277
LEU A 291
ALA A 292
 None
 1.42A 1xlsA-1tdjA:
undetectable		 1xlsA-1tdjA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		6 / 12 ILE A 270
ALA A 294
ALA A 273
LEU A 277
LEU A 291
ALA A 292
 None
 1.42A 1xlsB-1tdjA:
undetectable		 1xlsB-1tdjA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		6 / 12 ILE A 270
ALA A 294
ALA A 273
LEU A 277
LEU A 291
ALA A 292
 None
 1.42A 1xlsC-1tdjA:
undetectable		 1xlsC-1tdjA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		6 / 12 ILE A 270
ALA A 294
ALA A 273
LEU A 277
LEU A 291
ALA A 292
 None
 1.42A 1xlsD-1tdjA:
undetectable		 1xlsD-1tdjA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 GLY A  88
HIS A  90
ALA A 114
THR A 113
ALA A 120
 None
 1.01A 2gluB-1tdjA:
2.0		 2gluB-1tdjA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 GLY A 295
ALA A 294
ILE A 313
ALA A 239
ILE A 270
 None
 0.81A 2rkfB-1tdjA:
undetectable		 2rkfB-1tdjA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 ILE A 395
LEU A 341
VAL A 364
GLU A 366
ILE A 379
 None
 1.18A 2vn0A-1tdjA:
undetectable		 2vn0A-1tdjA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 ILE A 262
ILE A 263
ALA A 243
VAL A 244
PHE A 238
 None
 0.85A 2yvlA-1tdjA:
2.5		 2yvlA-1tdjA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 ILE A 262
ILE A 263
ALA A 243
VAL A 244
PHE A 238
 None
 0.89A 2yvlB-1tdjA:
2.6		 2yvlB-1tdjA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 LEU A 409
CYH A 356
ALA A 339
VAL A 383
LEU A 448
 None
 1.26A 3b0wB-1tdjA:
undetectable		 3b0wB-1tdjA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 ILE A 379
LEU A 451
ILE A 460
SER A 461
ILE A 345
 None
 1.11A 3cd2A-1tdjA:
2.2		 3cd2A-1tdjA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 ALA A 294
ALA A 292
PRO A 186
VAL A 242
VAL A 265
 None
None
None
PLP  A 962 (-4.8A)
None
 1.26A 3cwkA-1tdjA:
undetectable		 3cwkA-1tdjA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 LEU A 220
ALA A 211
ALA A 193
VAL A 198
VAL A 209
 None
 1.14A 3cwkA-1tdjA:
undetectable		 3cwkA-1tdjA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 PHE A  61
TYR A  16
GLY A  65
GLY A 165
VAL A  94
 PLP  A 962 (-4.6A)
None
None
None
None
 1.32A 3dlcA-1tdjA:
3.3		 3dlcA-1tdjA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 ARG A  64
GLN A 166
GLY A 167
GLY A  65
ALA A  23
 None
 0.97A 3kkzB-1tdjA:
2.6		 3kkzB-1tdjA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 GLY A  72
GLY A 165
GLY A  65
LEU A  63
ALA A  23
 None
 0.92A 3kkzB-1tdjA:
2.6		 3kkzB-1tdjA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		3 / 3 GLU A 308
LEU A 310
LEU A 174
 None
 0.61A 3ohtA-1tdjA:
undetectable		 3ohtA-1tdjA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		3 / 3 GLU A 308
LEU A 310
LEU A 174
 None
 0.62A 3ohtB-1tdjA:
undetectable		 3ohtB-1tdjA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 GLY A  65
ALA A  66
ILE A  83
GLY A  72
VAL A 154
 None
 0.97A 3ucbA-1tdjA:
undetectable		 3ucbA-1tdjA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 GLY A  65
ALA A  66
ILE A  83
GLY A  72
VAL A 154
 None
 0.98A 3ucbB-1tdjA:
undetectable		 3ucbB-1tdjA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 PRO A 186
LEU A 192
LEU A 169
LEU A 173
ILE A 313
 None
PLP  A 962 (-4.5A)
None
None
None
 1.04A 4a7aB-1tdjA:
undetectable		 4a7aB-1tdjA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		3 / 3 TRP A 153
GLN A   5
THR A 152
 None
 1.01A 4m2xA-1tdjA:
2.2		 4m2xA-1tdjA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		3 / 3 SER A 315
ALA A 285
VAL A 284
 PLP  A 962 (-3.1A)
None
None
 0.56A 4x20C-1tdjA:
2.3		 4x20C-1tdjA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		4 / 5 LEU A 192
ALA A 292
VAL A 209
ILE A 210
 PLP  A 962 (-4.5A)
None
None
None
 0.95A 4xe3A-1tdjA:
undetectable		 4xe3A-1tdjA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		4 / 9 ALA A 339
GLU A 338
LEU A 359
ILE A 379
 None
 0.90A 4xtaA-1tdjA:
undetectable		 4xtaA-1tdjA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 GLY A 188
GLY A 190
GLY A 191
LEU A 192
ALA A 214
 PLP  A 962 (-3.7A)
PLP  A 962 (-3.5A)
PLP  A 962 (-3.1A)
PLP  A 962 (-4.5A)
None
 0.78A 5c0oF-1tdjA:
2.0		 5c0oF-1tdjA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 GLY A 188
GLY A 190
GLY A 191
LEU A 192
LEU A 291
 PLP  A 962 (-3.7A)
PLP  A 962 (-3.5A)
PLP  A 962 (-3.1A)
PLP  A 962 (-4.5A)
None
 0.96A 5c0oF-1tdjA:
2.0		 5c0oF-1tdjA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 GLY A 190
GLY A 191
LEU A 192
GLU A 213
LEU A 291
 PLP  A 962 (-3.5A)
PLP  A 962 (-3.1A)
PLP  A 962 (-4.5A)
None
None
 0.78A 5c0oF-1tdjA:
2.0		 5c0oF-1tdjA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		4 / 7 TYR A 258
ALA A 193
GLY A 191
GLY A 167
 None
None
PLP  A 962 (-3.1A)
None
 0.84A 5e26A-1tdjA:
undetectable
5e26B-1tdjA:
undetectable		 5e26A-1tdjA:
22.56
5e26B-1tdjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		4 / 8 ALA A 339
LEU A 359
LEU A 396
LEU A 399
 None
 0.71A 5jqbA-1tdjA:
undetectable
5jqbB-1tdjA:
undetectable		 5jqbA-1tdjA:
21.69
5jqbB-1tdjA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 GLY A 316
VAL A  50
VAL A 284
LEU A 277
ALA A 273
 PLP  A 962 (-3.4A)
None
None
None
None
 0.94A 5kpcA-1tdjA:
undetectable		 5kpcA-1tdjA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 8 VAL A 209
ILE A 200
ALA A 170
PHE A 184
VAL A 185
 None
 1.12A 5l94A-1tdjA:
undetectable		 5l94A-1tdjA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		4 / 7 TYR A 299
ILE A 305
ILE A 300
ILE A  48
 None
 0.92A 5murB-1tdjA:
0.0		 5murB-1tdjA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 GLY A 316
HIS A  59
VAL A 319
SER A  60
VAL A 242
 PLP  A 962 (-3.4A)
None
None
PLP  A 962 ( 4.7A)
PLP  A 962 (-4.8A)
 1.01A 5n0oA-1tdjA:
undetectable		 5n0oA-1tdjA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 12 GLY A 316
HIS A  59
VAL A 319
SER A  60
VAL A 242
 PLP  A 962 (-3.4A)
None
None
PLP  A 962 ( 4.7A)
PLP  A 962 (-4.8A)
 1.03A 5n0oB-1tdjA:
undetectable		 5n0oB-1tdjA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		4 / 6 PHE A 238
LEU A 237
SER A 288
GLY A 241
 None
None
PLP  A 962 (-4.2A)
PLP  A 962 (-4.3A)
 1.04A 5o4yF-1tdjA:
undetectable		 5o4yF-1tdjA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		5 / 8 GLY A 382
LEU A 341
VAL A 407
ILE A 395
LEU A 385
 None
 1.01A 5vkqB-1tdjA:
undetectable
5vkqC-1tdjA:
undetectable		 5vkqB-1tdjA:
15.54
5vkqC-1tdjA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		6 / 11 VAL A 242
GLY A 241
ASP A 216
ALA A 214
SER A 288
LEU A 291
 PLP  A 962 (-4.8A)
PLP  A 962 (-4.3A)
None
None
PLP  A 962 (-4.2A)
None
 1.18A 5x6yA-1tdjA:
2.5		 5x6yA-1tdjA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		6 / 10 VAL A 242
GLY A 241
ASP A 216
ALA A 214
SER A 288
LEU A 291
 PLP  A 962 (-4.8A)
PLP  A 962 (-4.3A)
None
None
PLP  A 962 (-4.2A)
None
 1.16A 5x6yB-1tdjA:
2.7		 5x6yB-1tdjA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		6 / 12 ILE A 270
ALA A 294
ALA A 273
LEU A 277
LEU A 291
ALA A 292
 None
 1.42A 5z12B-1tdjA:
undetectable		 5z12B-1tdjA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1tdj BIOSYNTHETIC
THREONINE DEAMINASE
(Escherichia
coli) 		4 / 6 PHE A 355
VAL A 383
LEU A 396
LEU A 399
 None
 0.95A 6e43D-1tdjA:
undetectable		 6e43D-1tdjA:
22.85