SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tdt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE
(Mycobacterium
bovis) 		5 / 8 VAL A 194
VAL A 251
VAL A 233
SER A 200
LEU A 208
 None
 1.48A 1igxA-1tdtA:
undetectable		 1igxA-1tdtA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE
(Mycobacterium
bovis) 		4 / 6 ASP A 216
TYR A 215
TYR A 224
LEU A 208
 None
 1.04A 2w98A-1tdtA:
undetectable
2w98B-1tdtA:
undetectable		 2w98A-1tdtA:
23.14
2w98B-1tdtA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_B_SALB104_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE
(Mycobacterium
bovis) 		5 / 9 ARG A 226
VAL A 227
ILE A 214
TYR A 224
GLN A 210
 None
 1.09A 3hgxB-1tdtA:
undetectable		 3hgxB-1tdtA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE
(Mycobacterium
bovis) 		4 / 8 VAL A 227
VAL A 156
ASN A 181
GLY A 199
 None
 0.78A 3hjoB-1tdtA:
undetectable		 3hjoB-1tdtA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE
(Mycobacterium
bovis) 		5 / 9 ALA A 150
ILE A 178
VAL A 190
GLY A 163
ILE A 152
 None
 0.95A 3s43A-1tdtA:
undetectable		 3s43A-1tdtA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE
(Mycobacterium
bovis) 		6 / 11 ALA A 144
VAL A 140
VAL A 128
GLY A 147
LEU A 123
LEU A 158
 None
 1.18A 3sm2B-1tdtA:
undetectable		 3sm2B-1tdtA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE
(Mycobacterium
bovis) 		5 / 12 LEU A  59
ILE A 130
GLY A  36
GLY A 114
LEU A   4
 None
 1.16A 3uj7B-1tdtA:
undetectable		 3uj7B-1tdtA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE
(Mycobacterium
bovis) 		4 / 7 GLY A 147
VAL A 146
ILE A 130
PHE A  67
 None
 0.92A 4fglC-1tdtA:
undetectable		 4fglC-1tdtA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE
(Mycobacterium
bovis) 		3 / 3 ALA A  46
TRP A  53
VAL A  54
 None
 0.34A 4w9nC-1tdtA:
undetectable		 4w9nC-1tdtA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE
(Mycobacterium
bovis) 		5 / 12 VAL A 233
LEU A 208
THR A 212
VAL A 227
PRO A 228
 None
 1.16A 4xiwB-1tdtA:
undetectable
4xiwE-1tdtA:
undetectable		 4xiwB-1tdtA:
21.17
4xiwE-1tdtA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE
(Mycobacterium
bovis) 		3 / 3 GLU A 136
LYS A 154
ASN A 120
 None
 0.87A 4y1dA-1tdtA:
undetectable
4y1dD-1tdtA:
undetectable		 4y1dA-1tdtA:
25.55
4y1dD-1tdtA:
2.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE
(Mycobacterium
bovis) 		4 / 7 ILE A 177
GLY A 153
THR A 138
LEU A 158
 None
 0.89A 4ze3A-1tdtA:
undetectable		 4ze3A-1tdtA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE
(Mycobacterium
bovis) 		4 / 5 GLU A 218
LYS A 255
ASP A 216
GLU A 221
 None
 1.06A 5a06A-1tdtA:
0.0		 5a06A-1tdtA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE
(Mycobacterium
bovis) 		4 / 8 ILE A 177
GLY A 153
THR A 138
LEU A 158
 None
 0.87A 5eseA-1tdtA:
1.6		 5eseA-1tdtA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE
(Mycobacterium
bovis) 		4 / 8 ILE A 177
GLY A 153
THR A 138
LEU A 158
 None
 0.88A 5esfA-1tdtA:
undetectable		 5esfA-1tdtA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE
(Mycobacterium
bovis) 		4 / 6 ILE A 117
VAL A 146
TYR A 133
VAL A 134
 None
 0.75A 5jwaH-1tdtA:
undetectable		 5jwaH-1tdtA:
19.77