SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1te4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 1te4 CONSERVED PROTEIN
MTH187
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A  58
ALA A  74
LEU A  61
SER A  66
 None
 0.97A 1tz8C-1te4A:
undetectable
1tz8D-1te4A:
undetectable		 1tz8C-1te4A:
20.42
1tz8D-1te4A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1te4 CONSERVED PROTEIN
MTH187
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 LEU A  62
GLY A  72
GLY A  67
ARG A  39
 None
 0.77A 2wd9A-1te4A:
undetectable		 2wd9A-1te4A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1te4 CONSERVED PROTEIN
MTH187
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 LEU A  62
GLY A  72
GLY A  67
ARG A  39
 None
 0.77A 2wd9B-1te4A:
undetectable		 2wd9B-1te4A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 1te4 CONSERVED PROTEIN
MTH187
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 VAL A  69
GLY A  72
ALA A  73
SER A  76
LEU A  58
 None
 1.09A 3nt1A-1te4A:
undetectable		 3nt1A-1te4A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 1te4 CONSERVED PROTEIN
MTH187
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 SER A  66
LEU A  58
ALA A  74
LEU A  61
 None
 0.94A 4ikjA-1te4A:
undetectable
4ikjB-1te4A:
undetectable		 4ikjA-1te4A:
20.42
4ikjB-1te4A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 1te4 CONSERVED PROTEIN
MTH187
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 SER A  71
GLY A  67
ARG A  70
PHE A  99
 None
 1.05A 4r82A-1te4A:
undetectable
4r82B-1te4A:
undetectable		 4r82A-1te4A:
21.86
4r82B-1te4A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1te4 CONSERVED PROTEIN
MTH187
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A  31
VAL A  69
GLY A  72
ALA A  73
SER A  76
 None
 1.17A 4rrwA-1te4A:
undetectable		 4rrwA-1te4A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1te4 CONSERVED PROTEIN
MTH187
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 VAL A  69
GLY A  72
ALA A  73
SER A  76
LEU A  58
 None
 1.18A 4rrwA-1te4A:
undetectable		 4rrwA-1te4A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1te4 CONSERVED PROTEIN
MTH187
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A  31
VAL A  69
GLY A  72
ALA A  73
SER A  76
 None
 1.14A 4rrwB-1te4A:
undetectable		 4rrwB-1te4A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1te4 CONSERVED PROTEIN
MTH187
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 VAL A  69
GLY A  72
ALA A  73
SER A  76
LEU A  58
 None
 1.16A 4rrwB-1te4A:
undetectable		 4rrwB-1te4A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1te4 CONSERVED PROTEIN
MTH187
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A  31
VAL A  69
GLY A  72
ALA A  73
SER A  76
 None
 1.17A 4rrzA-1te4A:
undetectable		 4rrzA-1te4A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1te4 CONSERVED PROTEIN
MTH187
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 VAL A  69
GLY A  72
ALA A  73
SER A  76
LEU A  58
 None
 1.18A 4rrzA-1te4A:
undetectable		 4rrzA-1te4A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1te4 CONSERVED PROTEIN
MTH187
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A  31
VAL A  69
GLY A  72
ALA A  73
SER A  76
 None
 1.14A 4rrzB-1te4A:
undetectable		 4rrzB-1te4A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1te4 CONSERVED PROTEIN
MTH187
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 VAL A  69
GLY A  72
ALA A  73
SER A  76
LEU A  58
 None
 1.16A 4rrzB-1te4A:
undetectable		 4rrzB-1te4A:
14.04