SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tez'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		5 / 8 ALA A 336
GLY A 330
PRO A 408
ILE A 354
ILE A 333
 None
 1.31A 1hshD-1tezA:
undetectable		 1hshD-1tezA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		5 / 11 ALA A  69
LEU A  21
ALA A  22
ALA A  26
LEU A 171
 None
 1.07A 1jinA-1tezA:
undetectable		 1jinA-1tezA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		3 / 3 ARG A  10
GLY A 106
ASP A 110
 HDF  A5486 (-4.9A)
HDF  A5486 (-3.1A)
None
 0.46A 1kf6A-1tezA:
undetectable
1kf6B-1tezA:
undetectable		 1kf6A-1tezA:
21.28
1kf6B-1tezA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		5 / 10 GLY A 141
GLN A 159
TYR A 146
ASN A 155
GLY A 143
 None
 1.25A 1kvlA-1tezA:
undetectable		 1kvlA-1tezA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		3 / 3 ARG A  14
ARG A  11
ARG A 255
 None
HDF  A5486 ( 4.9A)
None
 1.11A 1l7hA-1tezA:
undetectable		 1l7hA-1tezA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		3 / 3 TRP A 309
PHE A 312
TRP A 314
 None
 1.39A 1r15C-1tezA:
undetectable		 1r15C-1tezA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		3 / 3 TRP A 309
PHE A 312
TRP A 314
 None
 1.37A 1r15F-1tezA:
undetectable		 1r15F-1tezA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		3 / 3 TRP A 309
PHE A 312
TRP A 314
 None
 1.38A 1r15G-1tezA:
undetectable		 1r15G-1tezA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		3 / 3 TRP A 309
PHE A 312
TRP A 314
 None
 1.37A 1r15H-1tezA:
undetectable		 1r15H-1tezA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		3 / 3 LEU A  62
TYR A  66
GLY A  70
 None
 0.58A 2ocuA-1tezA:
undetectable		 2ocuA-1tezA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HTH_B_PRLB201_0
(EBRA REPRESSOR)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		5 / 9 LEU A  55
GLU A 103
TYR A 105
LEU A  42
ASP A  38
 HDF  A5486 (-4.7A)
HDF  A5486 (-3.7A)
None
HDF  A5486 (-4.2A)
None
 1.29A 3hthB-1tezA:
0.0		 3hthB-1tezA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		5 / 12 ALA A 257
ILE A 225
SER A 262
GLY A 242
ILE A 252
 None
None
None
FAD  A5485 (-3.5A)
None
 1.40A 3lbdA-1tezA:
undetectable		 3lbdA-1tezA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		3 / 3 GLN A 328
THR A 329
LEU A 341
 None
 0.57A 3ondA-1tezA:
undetectable		 3ondA-1tezA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		3 / 3 GLN A 328
THR A 329
LEU A 341
 None
 0.57A 3ondB-1tezA:
undetectable		 3ondB-1tezA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		4 / 6 GLU A 371
ASP A 382
ASP A 302
GLU A 103
 None
None
None
HDF  A5486 (-3.7A)
 1.33A 3vywA-1tezA:
undetectable		 3vywA-1tezA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_1
(MNMC2)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		4 / 4 GLU A 371
ASP A 382
ASP A 302
GLU A 103
 None
None
None
HDF  A5486 (-3.7A)
 1.21A 3vywB-1tezA:
1.1		 3vywB-1tezA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		4 / 5 GLU A 371
ASP A 382
ASP A 302
GLU A 103
 None
None
None
HDF  A5486 (-3.7A)
 1.28A 3vywD-1tezA:
undetectable		 3vywD-1tezA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		4 / 7 HIS A 265
ALA A 273
SER A 268
GLU A 272
 None
 0.77A 4hyfA-1tezA:
undetectable		 4hyfA-1tezA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		4 / 8 HIS A 265
ALA A 273
SER A 268
GLU A 272
 None
 0.78A 4hyfB-1tezA:
undetectable		 4hyfB-1tezA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		4 / 8 HIS A 265
ALA A 273
SER A 268
GLU A 272
 None
 0.85A 4hyfC-1tezA:
undetectable		 4hyfC-1tezA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA500_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		3 / 3 LYS A 401
ARG A 404
TRP A 392
 None
 1.23A 4i90A-1tezA:
0.0		 4i90A-1tezA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		4 / 8 ASP A 362
ASP A 335
GLY A 330
ALA A 412
 None
 0.89A 4m48A-1tezA:
undetectable		 4m48A-1tezA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		3 / 3 ILE A  41
ASP A  46
ARG A  11
 HDF  A5486 (-3.9A)
None
HDF  A5486 ( 4.9A)
 0.81A 4pstA-1tezA:
undetectable		 4pstA-1tezA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		3 / 3 ASP A 101
ARG A 255
ARG A  14
 HDF  A5486 (-3.5A)
None
None
 0.87A 4x5iA-1tezA:
0.2		 4x5iA-1tezA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		5 / 10 ILE A 354
PRO A 408
ILE A 422
LEU A 426
PRO A 451
 None
 1.14A 5ienB-1tezA:
undetectable		 5ienB-1tezA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		5 / 12 GLU A 441
GLY A 440
ILE A 333
ASP A 436
TYR A 450
 None
 1.01A 5kvaA-1tezA:
undetectable		 5kvaA-1tezA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		5 / 12 GLU A 441
GLY A 440
ILE A 333
ASP A 436
TYR A 450
 None
 1.02A 5kvaB-1tezA:
undetectable		 5kvaB-1tezA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		4 / 8 LEU A  91
GLN A  92
VAL A  96
LEU A   6
 None
 0.73A 6czmD-1tezA:
undetectable
6czmF-1tezA:
undetectable		 6czmD-1tezA:
22.06
6czmF-1tezA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Synechococcus
elongatus) 		5 / 12 SER A  44
LEU A 300
ASP A  46
ASP A 382
ILE A  41
 None
None
None
None
HDF  A5486 (-3.9A)
 1.19A 6dwnA-1tezA:
undetectable		 6dwnA-1tezA:
10.44