SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tfd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1tfd TRANSFERRIN
(Oryctolagus
cuniculus) 		4 / 6 TYR A  85
ASN A 292
TYR A  95
TYR A 188
 None
None
FE  A 950 ( 4.3A)
CO3  A 900 ( 3.6A)
 1.41A 1kiaA-1tfdA:
0.0		 1kiaA-1tfdA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1tfd TRANSFERRIN
(Oryctolagus
cuniculus) 		4 / 6 TYR A  85
ASN A 292
TYR A  95
TYR A 188
 None
None
FE  A 950 ( 4.3A)
CO3  A 900 ( 3.6A)
 1.42A 1kiaB-1tfdA:
0.0		 1kiaB-1tfdA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1tfd TRANSFERRIN
(Oryctolagus
cuniculus) 		4 / 7 TYR A  85
ASN A 292
TYR A  95
TYR A 188
 None
None
FE  A 950 ( 4.3A)
CO3  A 900 ( 3.6A)
 1.41A 1kiaC-1tfdA:
undetectable		 1kiaC-1tfdA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1tfd TRANSFERRIN
(Oryctolagus
cuniculus) 		4 / 7 TYR A  85
ASN A 292
TYR A  95
TYR A 188
 None
None
FE  A 950 ( 4.3A)
CO3  A 900 ( 3.6A)
 1.40A 1kiaD-1tfdA:
undetectable		 1kiaD-1tfdA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1tfd TRANSFERRIN
(Oryctolagus
cuniculus) 		4 / 6 TYR A  85
ASN A 292
TYR A  95
TYR A 188
 None
None
FE  A 950 ( 4.3A)
CO3  A 900 ( 3.6A)
 1.41A 1nbhA-1tfdA:
0.0		 1nbhA-1tfdA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1tfd TRANSFERRIN
(Oryctolagus
cuniculus) 		4 / 7 TYR A  85
ASN A 292
TYR A  95
TYR A 188
 None
None
FE  A 950 ( 4.3A)
CO3  A 900 ( 3.6A)
 1.40A 1nbhB-1tfdA:
undetectable		 1nbhB-1tfdA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1tfd TRANSFERRIN
(Oryctolagus
cuniculus) 		4 / 6 TYR A  85
ASN A 292
TYR A  95
TYR A 188
 None
None
FE  A 950 ( 4.3A)
CO3  A 900 ( 3.6A)
 1.41A 1nbhC-1tfdA:
0.0		 1nbhC-1tfdA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1tfd TRANSFERRIN
(Oryctolagus
cuniculus) 		4 / 7 TYR A  85
ASN A 292
TYR A  95
TYR A 188
 None
None
FE  A 950 ( 4.3A)
CO3  A 900 ( 3.6A)
 1.41A 1nbhD-1tfdA:
undetectable		 1nbhD-1tfdA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 1tfd TRANSFERRIN
(Oryctolagus
cuniculus) 		5 / 11 GLY A 190
ALA A 191
PHE A 192
ALA A 203
LEU A 100
 None
 1.08A 1ukbA-1tfdA:
undetectable		 1ukbA-1tfdA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 1tfd TRANSFERRIN
(Oryctolagus
cuniculus) 		4 / 8 SER A 189
PHE A 186
LEU A  62
LEU A  66
 None
 1.00A 2bfpB-1tfdA:
undetectable		 2bfpB-1tfdA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 1tfd TRANSFERRIN
(Oryctolagus
cuniculus) 		4 / 8 SER A 248
TYR A  95
TYR A 188
HIS A 249
 None
FE  A 950 ( 4.3A)
CO3  A 900 ( 3.6A)
FE  A 950 ( 3.4A)
 1.29A 2bteA-1tfdA:
undetectable		 2bteA-1tfdA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 1tfd TRANSFERRIN
(Oryctolagus
cuniculus) 		4 / 8 SER A 248
TYR A  95
TYR A 188
HIS A 249
 None
FE  A 950 ( 4.3A)
CO3  A 900 ( 3.6A)
FE  A 950 ( 3.4A)
 1.20A 2v0gA-1tfdA:
undetectable		 2v0gA-1tfdA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1tfd TRANSFERRIN
(Oryctolagus
cuniculus) 		5 / 12 GLY A 127
LEU A  66
SER A 125
ALA A 126
SER A 180
 CO3  A 900 (-3.6A)
None
CO3  A 900 (-4.1A)
CO3  A 900 (-3.6A)
None
 1.26A 2vmyB-1tfdA:
undetectable		 2vmyB-1tfdA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1tfd TRANSFERRIN
(Oryctolagus
cuniculus) 		4 / 5 PHE A 186
LEU A  66
GLY A 123
VAL A 159
 None
 0.89A 3wrkA-1tfdA:
undetectable		 3wrkA-1tfdA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 1tfd TRANSFERRIN
(Oryctolagus
cuniculus) 		4 / 5 PHE A 186
LEU A  66
GLY A 123
VAL A 159
 None
 0.90A 3wrkD-1tfdA:
undetectable		 3wrkD-1tfdA:
22.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 1tfd TRANSFERRIN
(Oryctolagus
cuniculus) 		4 / 7 ILE A 130
LEU A 134
HIS A 242
ALA A 244
 None
 0.47A 4g77A-1tfdA:
34.6		 4g77A-1tfdA:
38.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1tfd TRANSFERRIN
(Oryctolagus
cuniculus) 		4 / 6 TYR A 188
ARG A 124
GLY A  65
SER A 125
 CO3  A 900 ( 3.6A)
CO3  A 900 (-3.5A)
None
CO3  A 900 (-4.1A)
 1.22A 5bphA-1tfdA:
undetectable		 5bphA-1tfdA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1tfd TRANSFERRIN
(Oryctolagus
cuniculus) 		4 / 5 GLY A 290
HIS A  14
SER A 182
SER A 180
 None
 1.07A 6jmjA-1tfdA:
undetectable		 6jmjA-1tfdA:
19.65