SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tfe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1tfe ELONGATION FACTOR TS
(Thermus
thermophilus) 		4 / 7 LEU A 157
VAL A 169
VAL A  74
ILE A 100
 None
 0.98A 1t87B-1tfeA:
undetectable		 1t87B-1tfeA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 1tfe ELONGATION FACTOR TS
(Thermus
thermophilus) 		4 / 8 MET A  98
ALA A  97
LEU A  96
GLN A  90
 None
 0.74A 3cldB-1tfeA:
0.0		 3cldB-1tfeA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 1tfe ELONGATION FACTOR TS
(Thermus
thermophilus) 		4 / 6 VAL A 154
ASN A 104
TYR A 150
GLU A 117
 None
 1.21A 3q5sA-1tfeA:
undetectable		 3q5sA-1tfeA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1tfe ELONGATION FACTOR TS
(Thermus
thermophilus) 		4 / 4 VAL A 108
ILE A 173
ASN A  77
VAL A  74
 None
 1.35A 5ajqA-1tfeA:
undetectable		 5ajqA-1tfeA:
18.67